The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program

Jing Cai, Nailing Zhang, Yonggang Zheng, Roeland F de Wilde, Anirban Maitra, Duojia Pan

Research output: Contribution to journalArticleAcademicpeer-review

401 Citations (Scopus)

Abstract

Although a developmental role for Hippo signaling in organ size control is well appreciated, how this pathway functions in tissue regeneration is largely unknown. Here we address this issue using a dextran sodium sulfate (DSS)-induced colonic regeneration model. We find that regenerating crypts express elevated Yes-associated protein (YAP) levels. Inactivation of YAP causes no obvious intestinal defects under normal homeostasis, but severely impairs DSS-induced intestinal regeneration. Conversely, hyperactivation of YAP results in widespread early-onset polyp formation following DSS treatment. Thus, the YAP oncoprotein must be exquisitely controlled in tissue regeneration to allow compensatory proliferation and prevent the intrinsic oncogenic potential of a tissue regeneration program.

Original languageEnglish
Pages (from-to)2383-8
Number of pages6
JournalGenes & Development
Volume24
Issue number21
DOIs
Publication statusPublished - 1 Nov 2010
Externally publishedYes

Fingerprint

Dive into the research topics of 'The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program'. Together they form a unique fingerprint.

Cite this