The human kidney capsule contains a functionally distinct mesenchymal stromal cell population

Daniëlle G. Leuning, Marten A. Engelse, Ellen Lievers, Roel Bijkerk, Marlies E.J. Reinders, Hetty C. De Boer, Cees Van Kooten, Ton J. Rabelink*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Scopus)
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Abstract

We recently demonstrated that the adult human kidney cortex contains a perivascular stromal cell (kPSC) that shows organotypic properties and is important for repair and stabilisation of kidney function. Not only the kidney cortex but also the kidney capsule contains stromal cells that are important for the three dimensional organisation of the kidney during nephrogenesis. They provide the barrier function of the capsule which is critical for homeostatic processes such as pressure natriuresis. We postulated that stromal cells derived from the kidney capsule may therefore also have specific properties and functions. To this end, we isolated these capsule mesenchymal stromal cells (cMSC) from human cadaveric kidneys that were not suitable for transplantation. There were several similarities between cMSCs and kPSCs including support of vascular plexus formation, phenotypic marker expression and resistance against myofibroblast transformation. However, compared to kPSCs, cMSCs showed distinct mRNA and miRNA expression profiles, showed increased immunosuppressive capacity, and displayed strongly reduced HGF production, contributing to the inability to enhance kidney epithelial repair. Therefore cMSCs are a distinct, novel human kidney-derived MSC-population and these data underpin the large functional diversity of phenotypic similar stromal cells in relation to their anatomic site, even within one organ.

Original languageEnglish
Article number0187118
JournalPLoS ONE
Volume12
Issue number12
DOIs
Publication statusPublished - 5 Dec 2017
Externally publishedYes

Bibliographical note

Funding Information:
The research leading to these results has received funding from the European Community’s Seventh Framework Program (FP7/2007-2013) under grant agreement number 305436 The research leading to these results has received funding from the European Community’s Seventh Framework Program (FP7/2007-2013) under grant agreement number 305436 (STELLAR).

Publisher Copyright:
© 2017 Leuning et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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