The IDEAL framework for machine perfusion in liver transplantation

Otto B. van Leeuwen; David Nasralla; Carlo D.L. Ceresa; COPE 2 Consortium; Philipp Dutkowski; Peter J. Friend; Gabriel C. Oniscu; Robert J. Porte; Vincent E. de Meijer

doi:10.1038/s41575-025-01085-5

The IDEAL framework for machine perfusion in liver transplantation

Otto B. van Leeuwen
, David Nasralla
, Carlo D.L. Ceresa
, COPE 2 Consortium
, Philipp Dutkowski
, Peter J. Friend
, Gabriel C. Oniscu
, Robert J. Porte
, Vincent E. de Meijer^*

^*Corresponding author for this work

Surgery

University Medical Centre Groningen
Royal Free London NHS Foundation Trust
University of Basel
University of Oxford
Karolinska Institutet

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

3 Citations (Scopus)

Abstract

Liver transplantation is challenged by organ scarcity and ageing donors. Machine perfusion is a promising technique to enhance organ preservation and assessment, improving liver utilization and patient outcomes. Here, we discuss current practices in machine perfusion using the IDEAL framework and outline the steps needed to advance this technology clinically.

Original language	English
Pages (from-to)	669-671
Number of pages	3
Journal	Nature Reviews Gastroenterology and Hepatology
Volume	22
Issue number	10
DOIs	https://doi.org/10.1038/s41575-025-01085-5
Publication status	Published - 1 Oct 2025

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© Springer Nature Limited 2025.

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abstract = "Liver transplantation is challenged by organ scarcity and ageing donors. Machine perfusion is a promising technique to enhance organ preservation and assessment, improving liver utilization and patient outcomes. Here, we discuss current practices in machine perfusion using the IDEAL framework and outline the steps needed to advance this technology clinically.",

author = "\{van Leeuwen\}, \{Otto B.\} and David Nasralla and Ceresa, \{Carlo D.L.\} and \{COPE 2 Consortium\} and Philipp Dutkowski and Friend, \{Peter J.\} and Oniscu, \{Gabriel C.\} and Porte, \{Robert J.\} and \{de Meijer\}, \{Vincent E.\}",

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AU - van Leeuwen, Otto B.

AU - Nasralla, David

AU - Ceresa, Carlo D.L.

AU - COPE 2 Consortium

AU - Dutkowski, Philipp

AU - Friend, Peter J.

AU - Oniscu, Gabriel C.

AU - Porte, Robert J.

AU - de Meijer, Vincent E.

PY - 2025/10/1

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N2 - Liver transplantation is challenged by organ scarcity and ageing donors. Machine perfusion is a promising technique to enhance organ preservation and assessment, improving liver utilization and patient outcomes. Here, we discuss current practices in machine perfusion using the IDEAL framework and outline the steps needed to advance this technology clinically.

AB - Liver transplantation is challenged by organ scarcity and ageing donors. Machine perfusion is a promising technique to enhance organ preservation and assessment, improving liver utilization and patient outcomes. Here, we discuss current practices in machine perfusion using the IDEAL framework and outline the steps needed to advance this technology clinically.

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U2 - 10.1038/s41575-025-01085-5

DO - 10.1038/s41575-025-01085-5

M3 - Comment/Letter to the editor

C2 - 40523963

AN - SCOPUS:105017324961

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EP - 671

JO - Nature Reviews Gastroenterology and Hepatology

JF - Nature Reviews Gastroenterology and Hepatology

IS - 10

ER -

The IDEAL framework for machine perfusion in liver transplantation

Abstract

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