The Impact of Cancer-Related Fatigue on HRQOL in Survivors of Childhood Cancer: A DCCSS LATER Study

Adriaan Penson; Iris Walraven; the Dutch LATER Study group; Ewald Bronkhorst; Heleen Maurice-Stam; Martha A. Grootenhuis; Margriet Van der Heiden-Van der Loo; Wim J.E. Tissing; Helena J.H. Van der Pal; Andrica C.H. De Vries; Dorine Bresters; Cécile Ronckers; Marry M. Van den Heuvel; Sebastian J.C.M.M. Neggers; Birgitta A.B. Versluys; Marloes Louwerens; Saskia M.F. Pluijm; Leontien C.M. Kremer; Nicole Blijlevens; Eline Van Dulmen-Den Broeder; Hans Knoop; Jacqueline Loonen

doi:10.3390/cancers14122851

The Impact of Cancer-Related Fatigue on HRQOL in Survivors of Childhood Cancer: A DCCSS LATER Study

Adriaan Penson^*, Iris Walraven, the Dutch LATER Study group, Ewald Bronkhorst, Heleen Maurice-Stam, Martha A. Grootenhuis, Margriet Van der Heiden-Van der Loo, Wim J.E. Tissing, Helena J.H. Van der Pal, Andrica C.H. De Vries, Dorine Bresters, Cécile Ronckers, Marry M. Van den Heuvel, Sebastian J.C.M.M. Neggers, Birgitta A.B. Versluys, Marloes Louwerens, Saskia M.F. Pluijm, Leontien C.M. Kremer, Nicole Blijlevens, Eline Van Dulmen-Den BroederHans Knoop, Jacqueline Loonen

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Background: Early detection and management of late effects of treatment and their impact on health-related quality of life (HRQOL) has become a key goal of childhood cancer survivorship care. One of the most prevalent late effects is chronic fatigue (CF). The current study aimed to investigate the association between CF and HRQOL in a nationwide cohort of CCS. Methods: Participants were included from the Dutch Childhood Cancer Survivor Study (DCCSS) LATER cohort, a nationwide cohort of CCS. Participants completed the Checklist Individual Strength (CIS) to indicate CF (CIS fatigue severity subscale ≥ 35 and duration of symptoms ≥6 months) and the Short Form-36 (SF-36) and TNO (Netherlands Organization for Applied Scientific Research) and AZL (Leiden University Medical Centre) Adult’s Health-Related Quality of Life questionnaire (TAAQOL) as measures for HRQOL. Differences in mean HRQOL domain scores between CF and non-CF participants were investigated using independent samples t-tests and ANCOVA to adjust for age and sex. The association between CF and impaired HRQOL (scoring ≥ 2 SD below the population norm) was investigated using logistic regression analyses, adjusting for confounders. Results: A total of 1695 participants were included in the study. Mean HRQOL domain scores were significantly lower in participants with CF. In addition, CF was associated with impaired HRQOL on all of the domains (except physical functioning) with adjusted odds ratios ranging from 2.1 (95% CI 1.3–3.4; sexuality domain) to 30.4 (95% CI 16.4–56.2; vitality domain). Conclusions: CF is associated with impaired HRQOL, urging for the screening and regular monitoring of fatigue, and developing possible preventative programs and interventions.

Original language	English
Article number	2851
Journal	Cancers
Volume	14
Issue number	12
DOIs	https://doi.org/10.3390/cancers14122851
Publication status	Published - 1 Jun 2022

Bibliographical note

Funding Information:
Acknowledgments: The authors would like to thank all cancer survivors participating in the study and the VOKK and VOX for their contribution to the DCCSS LATER study. The authors thank Iridi Stollman for her contribution to the design and illustration of the Figures and the authors thank the complete LATER Study Group for their contribution to the study. The DCCSS LATER program was funded by KIKA/ODAS (grant 171 ‘DCOG LATER program’) and the Dutch Cancer Society (grant KUN 2014-6985).

Funding Information:
Funding: The DCCSS LATER program was supported by ‘stichting Kinderen Kankervrij’ (KIKA)&ODAS (grant 171 ‘DCOG LATER program’) and the Dutch Cancer Society (grant KUN 2014-6985).

Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.

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Penson, A., Walraven, I., the Dutch LATER Study group, Bronkhorst, E., Maurice-Stam, H., Grootenhuis, M. A., Van der Heiden-Van der Loo, M., Tissing, W. J. E., Van der Pal, H. J. H., De Vries, A. C. H., Bresters, D., Ronckers, C., Van den Heuvel, M. M., Neggers, S. J. C. M. M., Versluys, B. A. B., Louwerens, M., Pluijm, S. M. F., Kremer, L. C. M., Blijlevens, N., ... Loonen, J. (2022). The Impact of Cancer-Related Fatigue on HRQOL in Survivors of Childhood Cancer: A DCCSS LATER Study. Cancers, 14(12), Article 2851. https://doi.org/10.3390/cancers14122851

@article{c00fe34a1b0443c2844d6b3f36be7a5c,

title = "The Impact of Cancer-Related Fatigue on HRQOL in Survivors of Childhood Cancer: A DCCSS LATER Study",

abstract = "Background: Early detection and management of late effects of treatment and their impact on health-related quality of life (HRQOL) has become a key goal of childhood cancer survivorship care. One of the most prevalent late effects is chronic fatigue (CF). The current study aimed to investigate the association between CF and HRQOL in a nationwide cohort of CCS. Methods: Participants were included from the Dutch Childhood Cancer Survivor Study (DCCSS) LATER cohort, a nationwide cohort of CCS. Participants completed the Checklist Individual Strength (CIS) to indicate CF (CIS fatigue severity subscale ≥ 35 and duration of symptoms ≥6 months) and the Short Form-36 (SF-36) and TNO (Netherlands Organization for Applied Scientific Research) and AZL (Leiden University Medical Centre) Adult{\textquoteright}s Health-Related Quality of Life questionnaire (TAAQOL) as measures for HRQOL. Differences in mean HRQOL domain scores between CF and non-CF participants were investigated using independent samples t-tests and ANCOVA to adjust for age and sex. The association between CF and impaired HRQOL (scoring ≥ 2 SD below the population norm) was investigated using logistic regression analyses, adjusting for confounders. Results: A total of 1695 participants were included in the study. Mean HRQOL domain scores were significantly lower in participants with CF. In addition, CF was associated with impaired HRQOL on all of the domains (except physical functioning) with adjusted odds ratios ranging from 2.1 (95% CI 1.3–3.4; sexuality domain) to 30.4 (95% CI 16.4–56.2; vitality domain). Conclusions: CF is associated with impaired HRQOL, urging for the screening and regular monitoring of fatigue, and developing possible preventative programs and interventions.",

author = "Adriaan Penson and Iris Walraven and {the Dutch LATER Study group} and Ewald Bronkhorst and Heleen Maurice-Stam and Grootenhuis, {Martha A.} and {Van der Heiden-Van der Loo}, Margriet and Tissing, {Wim J.E.} and {Van der Pal}, {Helena J.H.} and {De Vries}, {Andrica C.H.} and Dorine Bresters and C{\'e}cile Ronckers and {Van den Heuvel}, {Marry M.} and Neggers, {Sebastian J.C.M.M.} and Versluys, {Birgitta A.B.} and Marloes Louwerens and Pluijm, {Saskia M.F.} and Kremer, {Leontien C.M.} and Nicole Blijlevens and {Van Dulmen-Den Broeder}, Eline and Hans Knoop and Jacqueline Loonen",

note = "Funding Information: Acknowledgments: The authors would like to thank all cancer survivors participating in the study and the VOKK and VOX for their contribution to the DCCSS LATER study. The authors thank Iridi Stollman for her contribution to the design and illustration of the Figures and the authors thank the complete LATER Study Group for their contribution to the study. The DCCSS LATER program was funded by KIKA/ODAS (grant 171 {\textquoteleft}DCOG LATER program{\textquoteright}) and the Dutch Cancer Society (grant KUN 2014-6985). Funding Information: Funding: The DCCSS LATER program was supported by {\textquoteleft}stichting Kinderen Kankervrij{\textquoteright} (KIKA)&ODAS (grant 171 {\textquoteleft}DCOG LATER program{\textquoteright}) and the Dutch Cancer Society (grant KUN 2014-6985). Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2022",

month = jun,

day = "1",

doi = "10.3390/cancers14122851",

language = "English",

volume = "14",

journal = "Cancers",

issn = "2072-6694",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "12",

}

Penson, A, Walraven, I, the Dutch LATER Study group, Bronkhorst, E, Maurice-Stam, H, Grootenhuis, MA, Van der Heiden-Van der Loo, M, Tissing, WJE, Van der Pal, HJH, De Vries, ACH, Bresters, D, Ronckers, C, Van den Heuvel, MM , Neggers, SJCMM, Versluys, BAB, Louwerens, M, Pluijm, SMF, Kremer, LCM, Blijlevens, N, Van Dulmen-Den Broeder, E, Knoop, H & Loonen, J 2022, 'The Impact of Cancer-Related Fatigue on HRQOL in Survivors of Childhood Cancer: A DCCSS LATER Study', Cancers, vol. 14, no. 12, 2851. https://doi.org/10.3390/cancers14122851

TY - JOUR

T1 - The Impact of Cancer-Related Fatigue on HRQOL in Survivors of Childhood Cancer

T2 - A DCCSS LATER Study

AU - Penson, Adriaan

AU - Walraven, Iris

AU - the Dutch LATER Study group

AU - Bronkhorst, Ewald

AU - Maurice-Stam, Heleen

AU - Grootenhuis, Martha A.

AU - Van der Heiden-Van der Loo, Margriet

AU - Tissing, Wim J.E.

AU - Van der Pal, Helena J.H.

AU - De Vries, Andrica C.H.

AU - Bresters, Dorine

AU - Ronckers, Cécile

AU - Van den Heuvel, Marry M.

AU - Neggers, Sebastian J.C.M.M.

AU - Versluys, Birgitta A.B.

AU - Louwerens, Marloes

AU - Pluijm, Saskia M.F.

AU - Kremer, Leontien C.M.

AU - Blijlevens, Nicole

AU - Van Dulmen-Den Broeder, Eline

AU - Knoop, Hans

AU - Loonen, Jacqueline

N1 - Funding Information: Acknowledgments: The authors would like to thank all cancer survivors participating in the study and the VOKK and VOX for their contribution to the DCCSS LATER study. The authors thank Iridi Stollman for her contribution to the design and illustration of the Figures and the authors thank the complete LATER Study Group for their contribution to the study. The DCCSS LATER program was funded by KIKA/ODAS (grant 171 ‘DCOG LATER program’) and the Dutch Cancer Society (grant KUN 2014-6985). Funding Information: Funding: The DCCSS LATER program was supported by ‘stichting Kinderen Kankervrij’ (KIKA)&ODAS (grant 171 ‘DCOG LATER program’) and the Dutch Cancer Society (grant KUN 2014-6985). Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2022/6/1

Y1 - 2022/6/1

N2 - Background: Early detection and management of late effects of treatment and their impact on health-related quality of life (HRQOL) has become a key goal of childhood cancer survivorship care. One of the most prevalent late effects is chronic fatigue (CF). The current study aimed to investigate the association between CF and HRQOL in a nationwide cohort of CCS. Methods: Participants were included from the Dutch Childhood Cancer Survivor Study (DCCSS) LATER cohort, a nationwide cohort of CCS. Participants completed the Checklist Individual Strength (CIS) to indicate CF (CIS fatigue severity subscale ≥ 35 and duration of symptoms ≥6 months) and the Short Form-36 (SF-36) and TNO (Netherlands Organization for Applied Scientific Research) and AZL (Leiden University Medical Centre) Adult’s Health-Related Quality of Life questionnaire (TAAQOL) as measures for HRQOL. Differences in mean HRQOL domain scores between CF and non-CF participants were investigated using independent samples t-tests and ANCOVA to adjust for age and sex. The association between CF and impaired HRQOL (scoring ≥ 2 SD below the population norm) was investigated using logistic regression analyses, adjusting for confounders. Results: A total of 1695 participants were included in the study. Mean HRQOL domain scores were significantly lower in participants with CF. In addition, CF was associated with impaired HRQOL on all of the domains (except physical functioning) with adjusted odds ratios ranging from 2.1 (95% CI 1.3–3.4; sexuality domain) to 30.4 (95% CI 16.4–56.2; vitality domain). Conclusions: CF is associated with impaired HRQOL, urging for the screening and regular monitoring of fatigue, and developing possible preventative programs and interventions.

AB - Background: Early detection and management of late effects of treatment and their impact on health-related quality of life (HRQOL) has become a key goal of childhood cancer survivorship care. One of the most prevalent late effects is chronic fatigue (CF). The current study aimed to investigate the association between CF and HRQOL in a nationwide cohort of CCS. Methods: Participants were included from the Dutch Childhood Cancer Survivor Study (DCCSS) LATER cohort, a nationwide cohort of CCS. Participants completed the Checklist Individual Strength (CIS) to indicate CF (CIS fatigue severity subscale ≥ 35 and duration of symptoms ≥6 months) and the Short Form-36 (SF-36) and TNO (Netherlands Organization for Applied Scientific Research) and AZL (Leiden University Medical Centre) Adult’s Health-Related Quality of Life questionnaire (TAAQOL) as measures for HRQOL. Differences in mean HRQOL domain scores between CF and non-CF participants were investigated using independent samples t-tests and ANCOVA to adjust for age and sex. The association between CF and impaired HRQOL (scoring ≥ 2 SD below the population norm) was investigated using logistic regression analyses, adjusting for confounders. Results: A total of 1695 participants were included in the study. Mean HRQOL domain scores were significantly lower in participants with CF. In addition, CF was associated with impaired HRQOL on all of the domains (except physical functioning) with adjusted odds ratios ranging from 2.1 (95% CI 1.3–3.4; sexuality domain) to 30.4 (95% CI 16.4–56.2; vitality domain). Conclusions: CF is associated with impaired HRQOL, urging for the screening and regular monitoring of fatigue, and developing possible preventative programs and interventions.

UR - http://www.scopus.com/inward/record.url?scp=85131569116&partnerID=8YFLogxK

U2 - 10.3390/cancers14122851

DO - 10.3390/cancers14122851

M3 - Article

C2 - 35740518

AN - SCOPUS:85131569116

SN - 2072-6694

VL - 14

JO - Cancers

JF - Cancers

IS - 12

M1 - 2851

ER -

The Impact of Cancer-Related Fatigue on HRQOL in Survivors of Childhood Cancer: A DCCSS LATER Study

Abstract

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