TY - JOUR
T1 - The impact of clinically relevant health conditions on psychosocial outcomes in survivors of childhood cancer
T2 - results of the DCCSS-LATER study
AU - Maas, Anne
AU - Maurice-Stam, Heleen
AU - Feijen, Lieke E. A. M.
AU - the Dutch LATER Study group
AU - Teepen, Jop C.
AU - van der Aa-van Delden, Alied M.
AU - Streefkerk, Nina
AU - van Dulmen-den Broeder, Eline
AU - Tissing, Wim J. E.
AU - Loonen, Jacqueline J.
AU - van der Pal, Helena J. H.
AU - de Vries, Andrica C. H.
AU - van den Heuvel-eibrink, Marry M.
AU - Ronckers, Cecile
AU - Neggers, Sebastian
AU - Bresters, Dorine
AU - Louwerens, Marloes
AU - Versluys, Birgitta A. B.
AU - van der van der Loo, Margriet
AU - Kremer, Leontien C. M.
AU - Grootenhuis, Martha
N1 - Publisher Copyright:
© The Author(s) 2024.
PY - 2024/6/22
Y1 - 2024/6/22
N2 - Purpose: Investigate the association between presence, number and type of clinically relevant health conditions and a range of psychosocial outcomes (emotional, social, cognitive, physical) in survivors of childhood cancer (CCS). Methods: CCS from the Dutch Childhood Cancer Survivor Study (DCCSS)-LATER cohort (diagnosed between 1963–2001, attained age ≥ 18, diagnosed < 18, ≥ 5 years since diagnosis) completed a questionnaire on health conditions (2013–2014), and questionnaires on psychosocial outcomes (2017–2020): Hospital Anxiety and Depression Scale, Short form 36, TNO-AZL Questionnaire for Adult Health-Related Quality of Life, and the Self-Rating Scale for Post-Traumatic Stress Disorder. Associations among health conditions and psychosocial outcomes were assessed with regression analysis, adjusting for attained age, sex, and time since diagnosis, and adjusting for multiple testing (p < 0.004). Results: A total of 1437 CCS, mean age 36.3 years, 51.1% female, ≥ 15 years since diagnosis, completed questionnaires on health and psychosocial outcomes. CCS with a clinically relevant health condition, and those with more conditions had worse emotional, social, and physical outcomes; regression coefficients were small to moderate. CCS with gastro-intestinal conditions, endocrine, nervous systems, eye, or ear conditions, and especially those with secondary malignant neoplasms, reported worse psychosocial functioning; regression coefficients were small/moderate to large. Conclusion and implications: Health care professionals should be aware of the increased risk for psychosocial problems among CCS with health conditions, especially for survivors with secondary malignant neoplasms, gastro-intestinal, endocrine, nervous system, eye, and ear conditions. CCS may benefit from psychological interventions to develop coping strategies to manage health conditions and psychosocial consequences of the cancer trajectory.
AB - Purpose: Investigate the association between presence, number and type of clinically relevant health conditions and a range of psychosocial outcomes (emotional, social, cognitive, physical) in survivors of childhood cancer (CCS). Methods: CCS from the Dutch Childhood Cancer Survivor Study (DCCSS)-LATER cohort (diagnosed between 1963–2001, attained age ≥ 18, diagnosed < 18, ≥ 5 years since diagnosis) completed a questionnaire on health conditions (2013–2014), and questionnaires on psychosocial outcomes (2017–2020): Hospital Anxiety and Depression Scale, Short form 36, TNO-AZL Questionnaire for Adult Health-Related Quality of Life, and the Self-Rating Scale for Post-Traumatic Stress Disorder. Associations among health conditions and psychosocial outcomes were assessed with regression analysis, adjusting for attained age, sex, and time since diagnosis, and adjusting for multiple testing (p < 0.004). Results: A total of 1437 CCS, mean age 36.3 years, 51.1% female, ≥ 15 years since diagnosis, completed questionnaires on health and psychosocial outcomes. CCS with a clinically relevant health condition, and those with more conditions had worse emotional, social, and physical outcomes; regression coefficients were small to moderate. CCS with gastro-intestinal conditions, endocrine, nervous systems, eye, or ear conditions, and especially those with secondary malignant neoplasms, reported worse psychosocial functioning; regression coefficients were small/moderate to large. Conclusion and implications: Health care professionals should be aware of the increased risk for psychosocial problems among CCS with health conditions, especially for survivors with secondary malignant neoplasms, gastro-intestinal, endocrine, nervous system, eye, and ear conditions. CCS may benefit from psychological interventions to develop coping strategies to manage health conditions and psychosocial consequences of the cancer trajectory.
UR - http://www.scopus.com/inward/record.url?scp=85196658527&partnerID=8YFLogxK
U2 - 10.1007/s11764-024-01617-z
DO - 10.1007/s11764-024-01617-z
M3 - Article
C2 - 38907800
SN - 1932-2259
JO - Journal of Cancer Survivorship
JF - Journal of Cancer Survivorship
ER -
