The Impact of Extracorporeal Life Support and Hypothermia on Drug Disposition in Critically III Infants and Children

E.D. Wildschut, Annewil van Saet, P Pokorna, Maurice Ahsman, John van den Anker, Dick Tibboel

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28 Citations (Scopus)


Extracorporeal membrane oxygenation (ECMO) support is an established lifesaving therapy for potentially reversible respiratory or cardiac failure. In 10% of all pediatric patients receiving ECMO, ECMO therapy is initiated during or after cardiopulmonary resuscitation. Therapeutic hypothermia is frequently used in children after cardiac arrest, despite the lack of randomized controlled trials that show its efficacy. Hypothermia is frequently used in children and neonates during cardiopulmonary bypass (CPB). By combining data from pharmacokinetic studies in children on ECM and CPB and during hypothermia, this review elucidates the possible effects of hypothermia during ECM on drug disposition.
Original languageUndefined/Unknown
Pages (from-to)1183-+
JournalPediatric Clinics of North America
Issue number5
Publication statusPublished - 2012

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