The Impact of Extracorporeal Life Support and Hypothermia on Drug Disposition in Critically III Infants and Children

E.D. Wildschut; Annewil van Saet; P Pokorna; Maurice Ahsman; John van den Anker; Dick Tibboel

doi:10.1016/j.pcl.2012.07.013

The Impact of Extracorporeal Life Support and Hypothermia on Drug Disposition in Critically III Infants and Children

E.D. Wildschut, Annewil van Saet, P Pokorna, Maurice Ahsman, John van den Anker, Dick Tibboel

Research output: Contribution to journal › Article › Academic › peer-review

28 Citations (Scopus)

Abstract

Extracorporeal membrane oxygenation (ECMO) support is an established lifesaving therapy for potentially reversible respiratory or cardiac failure. In 10% of all pediatric patients receiving ECMO, ECMO therapy is initiated during or after cardiopulmonary resuscitation. Therapeutic hypothermia is frequently used in children after cardiac arrest, despite the lack of randomized controlled trials that show its efficacy. Hypothermia is frequently used in children and neonates during cardiopulmonary bypass (CPB). By combining data from pharmacokinetic studies in children on ECM and CPB and during hypothermia, this review elucidates the possible effects of hypothermia during ECM on drug disposition.

Original language	Undefined/Unknown
Pages (from-to)	1183-+
Journal	Pediatric Clinics of North America
Volume	59
Issue number	5
DOIs	https://doi.org/10.1016/j.pcl.2012.07.013
Publication status	Published - 2012

Access to Document

10.1016/j.pcl.2012.07.013

http://hdl.handle.net/1765/62071

Cite this

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abstract = "Extracorporeal membrane oxygenation (ECMO) support is an established lifesaving therapy for potentially reversible respiratory or cardiac failure. In 10% of all pediatric patients receiving ECMO, ECMO therapy is initiated during or after cardiopulmonary resuscitation. Therapeutic hypothermia is frequently used in children after cardiac arrest, despite the lack of randomized controlled trials that show its efficacy. Hypothermia is frequently used in children and neonates during cardiopulmonary bypass (CPB). By combining data from pharmacokinetic studies in children on ECM and CPB and during hypothermia, this review elucidates the possible effects of hypothermia during ECM on drug disposition.",

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AU - Wildschut, E.D.

AU - van Saet, Annewil

AU - Pokorna, P

AU - Ahsman, Maurice

AU - van den Anker, John

AU - Tibboel, Dick

PY - 2012

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AB - Extracorporeal membrane oxygenation (ECMO) support is an established lifesaving therapy for potentially reversible respiratory or cardiac failure. In 10% of all pediatric patients receiving ECMO, ECMO therapy is initiated during or after cardiopulmonary resuscitation. Therapeutic hypothermia is frequently used in children after cardiac arrest, despite the lack of randomized controlled trials that show its efficacy. Hypothermia is frequently used in children and neonates during cardiopulmonary bypass (CPB). By combining data from pharmacokinetic studies in children on ECM and CPB and during hypothermia, this review elucidates the possible effects of hypothermia during ECM on drug disposition.

U2 - 10.1016/j.pcl.2012.07.013

DO - 10.1016/j.pcl.2012.07.013

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