TY - JOUR
T1 - The Inflammatory Cytokine Profile Associated With Liver Damage Is Broader and Stronger in Patients With Chronic Hepatitis B Compared to Patients With Acute Hepatitis B
AU - Johnson Valiente, Alexandra
AU - Liem, Kin Seng
AU - Schwarz, Kathleen B.
AU - Rosenthal, Philip
AU - Murray, Karen F.
AU - Mogul, Douglas
AU - Teckman, Jeffery
AU - Rodriguez-Baez, Norberto
AU - Schwarzenberg, Sarah Jane
AU - Feld, Jordan J.
AU - Wong, David K.
AU - Lewis-Ximenez, Lia L.
AU - Lauer, Georg
AU - Hansen, Bettina E.
AU - Ling, Simon C.
AU - Janssen, Harry L.A.
AU - Gehring, Adam J.
N1 - Publisher Copyright:
© 2021 The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: [email protected].
PY - 2022/2/1
Y1 - 2022/2/1
N2 - Liver damage in hepatitis B is immune driven and correlates with inflammatory markers in patient serum. There is no comparison of these markers to determine if inflammatory profiles are distinct to different types of liver damage across patients at different stages of disease. We measured 25 inflammatory markers in patients with acute hepatitis B and chronic hepatitis B with hepatitis B e antigen seroconversion and chronic patients stopping nucleoside analogue therapy. Myeloid markers dominated the inflammatory profile in all stages of hepatitis B. More inflammatory markers were detectable in chronic patients, including elevated concentrations of cytotoxic effectors Fas ligand, TRAIL, and TNF-α.
AB - Liver damage in hepatitis B is immune driven and correlates with inflammatory markers in patient serum. There is no comparison of these markers to determine if inflammatory profiles are distinct to different types of liver damage across patients at different stages of disease. We measured 25 inflammatory markers in patients with acute hepatitis B and chronic hepatitis B with hepatitis B e antigen seroconversion and chronic patients stopping nucleoside analogue therapy. Myeloid markers dominated the inflammatory profile in all stages of hepatitis B. More inflammatory markers were detectable in chronic patients, including elevated concentrations of cytotoxic effectors Fas ligand, TRAIL, and TNF-α.
UR - http://www.scopus.com/inward/record.url?scp=85123968446&partnerID=8YFLogxK
U2 - 10.1093/infdis/jiab373
DO - 10.1093/infdis/jiab373
M3 - Article
C2 - 34286845
AN - SCOPUS:85123968446
SN - 0022-1899
VL - 225
SP - 470
EP - 475
JO - The Journal of infectious diseases
JF - The Journal of infectious diseases
IS - 3
ER -