TY - JOUR
T1 - The influence of COPD on health-related quality of life independent of the influence of comorbidity
AU - Van Manen, Jeannette G.
AU - Bindels, Patrick J.E.
AU - Dekker, Friedo W.
AU - Bottema, Bernardus J.A.M.
AU - Van Der Zee, Jaring S.
AU - Ijzermans, C. Joris
AU - Schadé, Egbert
N1 - Funding Information:
This study was supported by Boehringer Ingelheim NL by supplying all materials and personnel for the lung function testing.
PY - 2003/12
Y1 - 2003/12
N2 - Background and Objective: The goal of this study was to determine the influence of chronic obstructive pulmonary disease (COPD) on health-related quality of life (HRQL) independent of comorbidity. Methods: Patients with COPD in general practice, ≥40 years, were selected. To recruit controls, a random sample of persons without COPD and ≥40 years, was taken. HRQL was assessed with the SF-36 and comorbidity was determined by questionnaire. Results: The influence of COPD on HRQL independent of comorbidity (represented by adjusted regression coefficients) was significant for physical functioning (-27.6), role functioning due to physical problems (-21.6), vitality (-14.4), and general health (-25.7), and was minor and not significant for social functioning (-5.6), mental health (-1.3), role functioning due to emotional problems (-2.7), and bodily pain (-2.5). Comorbidity contributed significantly to the HRQL of all domains (-7.6 to -27.1). Conclusion: COPD patients can be impaired in all domains of HRQL. However, impairments in physical functioning, vitality, and general health are related to COPD and to some extent to comorbidity, while impairments in social and emotional functioning do not seem to be related to COPD, but only to comorbidity.
AB - Background and Objective: The goal of this study was to determine the influence of chronic obstructive pulmonary disease (COPD) on health-related quality of life (HRQL) independent of comorbidity. Methods: Patients with COPD in general practice, ≥40 years, were selected. To recruit controls, a random sample of persons without COPD and ≥40 years, was taken. HRQL was assessed with the SF-36 and comorbidity was determined by questionnaire. Results: The influence of COPD on HRQL independent of comorbidity (represented by adjusted regression coefficients) was significant for physical functioning (-27.6), role functioning due to physical problems (-21.6), vitality (-14.4), and general health (-25.7), and was minor and not significant for social functioning (-5.6), mental health (-1.3), role functioning due to emotional problems (-2.7), and bodily pain (-2.5). Comorbidity contributed significantly to the HRQL of all domains (-7.6 to -27.1). Conclusion: COPD patients can be impaired in all domains of HRQL. However, impairments in physical functioning, vitality, and general health are related to COPD and to some extent to comorbidity, while impairments in social and emotional functioning do not seem to be related to COPD, but only to comorbidity.
UR - http://www.scopus.com/inward/record.url?scp=0347480434&partnerID=8YFLogxK
U2 - 10.1016/S0895-4356(03)00208-7
DO - 10.1016/S0895-4356(03)00208-7
M3 - Article
C2 - 14680668
AN - SCOPUS:0347480434
SN - 0895-4356
VL - 56
SP - 1177
EP - 1184
JO - Journal of Clinical Epidemiology
JF - Journal of Clinical Epidemiology
IS - 12
ER -
