The influence of various anesthetics on the release and metabolism of thyroid hormones: Results of two clinical studies

U. Borner; M. Klimek; H. Schoengen; J. Lynch; C. Peschau; H. Schicha

doi:10.1097/00000539-199509000-00034

The influence of various anesthetics on the release and metabolism of thyroid hormones: Results of two clinical studies

U. Borner^*, M. Klimek, H. Schoengen, J. Lynch, C. Peschau, H. Schicha

^*Corresponding author for this work

Anesthesiology

Research output: Contribution to journal › Article › Academic › peer-review

18 Citations (Scopus)

Abstract

Normal functioning of the thyroid gland during surgery is important, but few data are available on the possible interactions between anesthesia and thyroid hormones. In two independent studies we examined the influence of different types of general anesthesia on the plasma levels of the thyroid hormones. They revealed an intraoperative increase of free thyroxine (fT₄) and total thyroxine (tT₄) in plasma to approximately 150% of preanesthesia levels when enflurane was used. No increase in thyroid-stimulating hormone(TSH) secretion was noted prior to this. The increase was not due to a quantitative change in the binding proteins. The plasma levels of fT₄ and fT₄ returned to normal postoperatively; however, no accompanying increase in plasma triiodothyronine levels was observed. Hence we assume the increase to be due to hormone release from thyroid and/or extrathyroidal stores-an intercompartmental shifting.

Original language	English
Pages (from-to)	612-618
Number of pages	7
Journal	Anesthesia and Analgesia
Volume	81
Issue number	3
DOIs	https://doi.org/10.1097/00000539-199509000-00034
Publication status	Published - 1995

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abstract = "Normal functioning of the thyroid gland during surgery is important, but few data are available on the possible interactions between anesthesia and thyroid hormones. In two independent studies we examined the influence of different types of general anesthesia on the plasma levels of the thyroid hormones. They revealed an intraoperative increase of free thyroxine (fT4) and total thyroxine (tT4) in plasma to approximately 150% of preanesthesia levels when enflurane was used. No increase in thyroid-stimulating hormone(TSH) secretion was noted prior to this. The increase was not due to a quantitative change in the binding proteins. The plasma levels of fT4 and fT4 returned to normal postoperatively; however, no accompanying increase in plasma triiodothyronine levels was observed. Hence we assume the increase to be due to hormone release from thyroid and/or extrathyroidal stores-an intercompartmental shifting.",

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The influence of various anesthetics on the release and metabolism of thyroid hormones: Results of two clinical studies

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