The Interplay between Maternal Smoking and Genes in Offspring Birth Weight

Rita Dias Pereira; Cornelius A. Rietveld; Hans van Kippersluis

doi:10.3368/JHR.1020-11266R2

The Interplay between Maternal Smoking and Genes in Offspring Birth Weight

Rita Dias Pereira, Cornelius A. Rietveld, Hans van Kippersluis

Research output: Contribution to journal › Article › Academic › peer-review

4 Citations (Scopus)

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Abstract

It is well established that birth weight is affected by the child’s genetic endowments and maternal smoking during pregnancy. Here, we investigate whether an interaction between genetic endowments and maternal smoking on birth weight exists. We instrument the maternal smoking decision with a genetic variant (rs1051730) located in the nicotine receptor gene CHRNA3 and deal with the underreporting of maternal smoking by using a biomarker of nicotine collected during pregnancy. We confirm that genetic endowments and maternal smoking negatively affect the child’s birth weight. However, we do not find evidence of meaningful interactions between genetic endowments and maternal smoking.

Original language	English
Pages (from-to)	400-433
Number of pages	34
Journal	Journal of Human Resources
Volume	60
Issue number	2
DOIs	https://doi.org/10.3368/JHR.1020-11266R2
Publication status	Published - 1 Mar 2025

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JEL Classification: I100 and I140

Publisher Copyright: © 2025 by the Board of Regents of the University of Wisconsin System

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400.fullFinal published version, 937 KBLicence: CC BY-NC-ND

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title = "The Interplay between Maternal Smoking and Genes in Offspring Birth Weight",

abstract = "It is well established that birth weight is affected by the child{\textquoteright}s genetic endowments and maternal smoking during pregnancy. Here, we investigate whether an interaction between genetic endowments and maternal smoking on birth weight exists. We instrument the maternal smoking decision with a genetic variant (rs1051730) located in the nicotine receptor gene CHRNA3 and deal with the underreporting of maternal smoking by using a biomarker of nicotine collected during pregnancy. We confirm that genetic endowments and maternal smoking negatively affect the child{\textquoteright}s birth weight. However, we do not find evidence of meaningful interactions between genetic endowments and maternal smoking.",

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The Interplay between Maternal Smoking and Genes in Offspring Birth Weight

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