TY - JOUR
T1 - The LifeLines Cohort Study
T2 - Prevalence and treatment of cardiovascular disease and risk factors
AU - van der Ende, M. Yldau
AU - Hartman, Minke H.T.
AU - Hagemeijer, Yanick
AU - Meems, Laura M.G.
AU - de Vries, Hendrik Sierd
AU - Stolk, Ronald P.
AU - de Boer, Rudolf A.
AU - Sijtsma, Anna
AU - van der Meer, Peter
AU - Rienstra, Michiel
AU - van der Harst, Pim
N1 - Publisher Copyright:
© 2016 The Authors
PY - 2017/2/1
Y1 - 2017/2/1
N2 - Background: The LifeLines Cohort Study is a large three-generation prospective study and Biobank. Recruitment and data collection started in 2006 and follow-up is planned for 30 years. The central aim of LifeLines is to understand healthy ageing in the 21st century. Here, the study design, methods, baseline and major cardiovascular phenotypes of the LifeLines Cohort Study are presented. Methods and results: Baseline cardiovascular phenotypes were defined in 9700 juvenile (8–18 years) and 152,180 adult (≥ 18 years) participants. Cardiovascular disease (CVD) was defined using ICD-10 criteria. At least one cardiovascular risk factor was present in 73% of the adult participants. The prevalence, adjusted for the Dutch population, was determined for risk factors (hypertension (33%), hypercholesterolemia (19%), diabetes (4%), overweight (56%), and current smoking (19%)) and CVD (myocardial infarction (1.8%), heart failure (1.0%), and atrial fibrillation (1.3%)). Overall CVD prevalence increased with age from 9% in participants < 65 years to 28% in participants ≥ 65 years. Of the participants with hypertension, hypercholesterolemia and diabetes, respectively 75%, 96% and 41% did not receive preventive pharmacotherapy. Conclusions: The contemporary LifeLines Cohort Study provides researchers with unique and novel opportunities to study environmental, phenotypic, and genetic risk factors for CVD and is expected to improve our knowledge on healthy ageing. In this contemporary Western cohort we identified a remarkable high percentage of untreated CVD risk factors suggesting that not all opportunities to reduce the CVD burden are utilised.
AB - Background: The LifeLines Cohort Study is a large three-generation prospective study and Biobank. Recruitment and data collection started in 2006 and follow-up is planned for 30 years. The central aim of LifeLines is to understand healthy ageing in the 21st century. Here, the study design, methods, baseline and major cardiovascular phenotypes of the LifeLines Cohort Study are presented. Methods and results: Baseline cardiovascular phenotypes were defined in 9700 juvenile (8–18 years) and 152,180 adult (≥ 18 years) participants. Cardiovascular disease (CVD) was defined using ICD-10 criteria. At least one cardiovascular risk factor was present in 73% of the adult participants. The prevalence, adjusted for the Dutch population, was determined for risk factors (hypertension (33%), hypercholesterolemia (19%), diabetes (4%), overweight (56%), and current smoking (19%)) and CVD (myocardial infarction (1.8%), heart failure (1.0%), and atrial fibrillation (1.3%)). Overall CVD prevalence increased with age from 9% in participants < 65 years to 28% in participants ≥ 65 years. Of the participants with hypertension, hypercholesterolemia and diabetes, respectively 75%, 96% and 41% did not receive preventive pharmacotherapy. Conclusions: The contemporary LifeLines Cohort Study provides researchers with unique and novel opportunities to study environmental, phenotypic, and genetic risk factors for CVD and is expected to improve our knowledge on healthy ageing. In this contemporary Western cohort we identified a remarkable high percentage of untreated CVD risk factors suggesting that not all opportunities to reduce the CVD burden are utilised.
UR - http://www.scopus.com/inward/record.url?scp=84996538758&partnerID=8YFLogxK
U2 - 10.1016/j.ijcard.2016.11.061
DO - 10.1016/j.ijcard.2016.11.061
M3 - Article
C2 - 27875724
AN - SCOPUS:84996538758
SN - 0167-5273
VL - 228
SP - 495
EP - 500
JO - International Journal of Cardiology
JF - International Journal of Cardiology
ER -
