The macrolide antibiotic azithromycin potently inhibits hepatitis E virus in cell culture models

Zhijiang Miao, Ruyi Zhang, Peifa Yu, Yang Li, Qiuwei Pan*, Yunlong Li

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)
6 Downloads (Pure)

Abstract

Hepatitis E virus (HEV) infection in immunocompromised patients, pregnant women and children requires treatment; however, no approved medication is currently available. The macrolide antibiotic azithromycin has been identified as a potent HEV inhibitor. Azithromycin inhibits HEV replication and viral protein expression in multiple cell culture models with genotype 1 and 3 strains. This is largely independent of its induction of an interferon-like response. Because it is safe and cheap, repurposing azithromycin for treating HEV infection is attractive, particularly in resource-limited settings.

Original languageEnglish
Article number106383
JournalInternational Journal of Antimicrobial Agents
Volume58
Issue number3
DOIs
Publication statusPublished - Sep 2021

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