The mammalian gene function resource: the international knockout mouse consortium

A Bradley, K Anastassiadis, Azzeddine Ayadi, JF Battey, C Bell, MC Birling, J Bottomley, SD Brown, A Burger, CJ Bult, W Bushell, FS Collins, C Desaintes, B Doe, A Economides, JT Eppig, RH Finnell, C D Fletcher, M Fray, D FrendeweyRH Friedel, Frank Grosveld, J Hansen, Y Herault, G Hicks, A Horlein, R Houghton, MH de Angelis, Danny Huylebroeck, V Iyer, PJ de Jong, JA Kadin, C Kaloff, K Kennedy, M (Manousos) Koutsourakis, KCK Lloyd, S Marschall, J Mason, C McKerlie, MP McLeod, H von Melchner, M Moore, AO Mujica, A Nagy, M Nefedov, LM Nutter, G Pavlovic, JL Peterson, J Pollock, R Ramirez-Solis, DE Rancourt, M Raspa, JE Remacle, M Ringwald, B Rosen, N Rosenthal, J Rossant, PR Noppinger, E Ryder, JZ Schick, F Schnutgen, P Schofield, C Seisenberger, M Selloum, EM Simpson, WC Skarnes, D Smedley, WL Stanford, AF Stewart, K Stone, K Swan, H Tadepally, L Teboul, GP Tocchini-Valentini, D Valenzuela, AP West, K Yamamura, Y Yoshinaga, W Wurst

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In 2007, the International Knockout Mouse Consortium (IKMC) made the ambitious promise to generate mutations in virtually every protein-coding gene of the mouse genome in a concerted worldwide action. Now, 5 years later, the IKMC members have developed high-throughput gene trapping and, in particular, gene-targeting pipelines and generated more than 17,400 mutant murine embryonic stem (ES) cell clones and more than 1,700 mutant mouse strains, most of them conditional. A common IKMC web portal ( has been established, allowing easy access to this unparalleled biological resource. The IKMC materials considerably enhance functional gene annotation of the mammalian genome and will have a major impact on future biomedical research.
Original languageUndefined/Unknown
Pages (from-to)580-586
Number of pages7
JournalMammalian Genome
Issue number9-10
Publication statusPublished - 2012

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