The mammalian gene function resource: the international knockout mouse consortium

A Bradley; K Anastassiadis; Azzeddine Ayadi; JF Battey; C Bell; MC Birling; J Bottomley; SD Brown; A Burger; CJ Bult; W Bushell; FS Collins; C Desaintes; B Doe; A Economides; JT Eppig; RH Finnell; C D Fletcher; M Fray; D Frendewey; RH Friedel; Frank Grosveld; J Hansen; Y Herault; G Hicks; A Horlein; R Houghton; MH de Angelis; Danny Huylebroeck; V Iyer; PJ de Jong; JA Kadin; C Kaloff; K Kennedy; M (Manousos) Koutsourakis; KCK Lloyd; S Marschall; J Mason; C McKerlie; MP McLeod; H von Melchner; M Moore; AO Mujica; A Nagy; M Nefedov; LM Nutter; G Pavlovic; JL Peterson; J Pollock; R Ramirez-Solis; DE Rancourt; M Raspa; JE Remacle; M Ringwald; B Rosen; N Rosenthal; J Rossant; PR Noppinger; E Ryder; JZ Schick; F Schnutgen; P Schofield; C Seisenberger; M Selloum; EM Simpson; WC Skarnes; D Smedley; WL Stanford; AF Stewart; K Stone; K Swan; H Tadepally; L Teboul; GP Tocchini-Valentini; D Valenzuela; AP West; K Yamamura; Y Yoshinaga; W Wurst

doi:10.1007/s00335-012-9422-2

The mammalian gene function resource: the international knockout mouse consortium

A Bradley, K Anastassiadis, Azzeddine Ayadi, JF Battey, C Bell, MC Birling, J Bottomley, SD Brown, A Burger, CJ Bult, W Bushell, FS Collins, C Desaintes, B Doe, A Economides, JT Eppig, RH Finnell, C D Fletcher, M Fray, D FrendeweyRH Friedel, Frank Grosveld, J Hansen, Y Herault, G Hicks, A Horlein, R Houghton, MH de Angelis, Danny Huylebroeck, V Iyer, PJ de Jong, JA Kadin, C Kaloff, K Kennedy, M (Manousos) Koutsourakis, KCK Lloyd, S Marschall, J Mason, C McKerlie, MP McLeod, H von Melchner, M Moore, AO Mujica, A Nagy, M Nefedov, LM Nutter, G Pavlovic, JL Peterson, J Pollock, R Ramirez-Solis, DE Rancourt, M Raspa, JE Remacle, M Ringwald, B Rosen, N Rosenthal, J Rossant, PR Noppinger, E Ryder, JZ Schick, F Schnutgen, P Schofield, C Seisenberger, M Selloum, EM Simpson, WC Skarnes, D Smedley, WL Stanford, AF Stewart, K Stone, K Swan, H Tadepally, L Teboul, GP Tocchini-Valentini, D Valenzuela, AP West, K Yamamura, Y Yoshinaga, W Wurst

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Abstract

In 2007, the International Knockout Mouse Consortium (IKMC) made the ambitious promise to generate mutations in virtually every protein-coding gene of the mouse genome in a concerted worldwide action. Now, 5 years later, the IKMC members have developed high-throughput gene trapping and, in particular, gene-targeting pipelines and generated more than 17,400 mutant murine embryonic stem (ES) cell clones and more than 1,700 mutant mouse strains, most of them conditional. A common IKMC web portal (www.knockoutmouse.org) has been established, allowing easy access to this unparalleled biological resource. The IKMC materials considerably enhance functional gene annotation of the mammalian genome and will have a major impact on future biomedical research.

Original language	Undefined/Unknown
Pages (from-to)	580-586
Number of pages	7
Journal	Mammalian Genome
Volume	23
Issue number	9-10
DOIs	https://doi.org/10.1007/s00335-012-9422-2
Publication status	Published - 2012

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EMC MGC-02-13-03

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10.1007/s00335-012-9422-2

REPUB_55958.pdfFinal published version, 254 KB

http://hdl.handle.net/1765/55958

Cite this

Bradley, A., Anastassiadis, K., Ayadi, A., Battey, JF., Bell, C., Birling, MC., Bottomley, J., Brown, SD., Burger, A., Bult, CJ., Bushell, W., Collins, FS., Desaintes, C., Doe, B., Economides, A., Eppig, JT., Finnell, RH., D Fletcher, C., Fray, M., ... Wurst, W. (2012). The mammalian gene function resource: the international knockout mouse consortium. Mammalian Genome, 23(9-10), 580-586. https://doi.org/10.1007/s00335-012-9422-2

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abstract = "In 2007, the International Knockout Mouse Consortium (IKMC) made the ambitious promise to generate mutations in virtually every protein-coding gene of the mouse genome in a concerted worldwide action. Now, 5 years later, the IKMC members have developed high-throughput gene trapping and, in particular, gene-targeting pipelines and generated more than 17,400 mutant murine embryonic stem (ES) cell clones and more than 1,700 mutant mouse strains, most of them conditional. A common IKMC web portal (www.knockoutmouse.org) has been established, allowing easy access to this unparalleled biological resource. The IKMC materials considerably enhance functional gene annotation of the mammalian genome and will have a major impact on future biomedical research.",

author = "A Bradley and K Anastassiadis and Azzeddine Ayadi and JF Battey and C Bell and MC Birling and J Bottomley and SD Brown and A Burger and CJ Bult and W Bushell and FS Collins and C Desaintes and B Doe and A Economides and JT Eppig and RH Finnell and {D Fletcher}, C and M Fray and D Frendewey and RH Friedel and Frank Grosveld and J Hansen and Y Herault and G Hicks and A Horlein and R Houghton and {de Angelis}, MH and Danny Huylebroeck and V Iyer and {de Jong}, PJ and JA Kadin and C Kaloff and K Kennedy and Koutsourakis, {M (Manousos)} and KCK Lloyd and S Marschall and J Mason and C McKerlie and MP McLeod and {von Melchner}, H and M Moore and AO Mujica and A Nagy and M Nefedov and LM Nutter and G Pavlovic and JL Peterson and J Pollock and R Ramirez-Solis and DE Rancourt and M Raspa and JE Remacle and M Ringwald and B Rosen and N Rosenthal and J Rossant and PR Noppinger and E Ryder and JZ Schick and F Schnutgen and P Schofield and C Seisenberger and M Selloum and EM Simpson and WC Skarnes and D Smedley and WL Stanford and AF Stewart and K Stone and K Swan and H Tadepally and L Teboul and GP Tocchini-Valentini and D Valenzuela and AP West and K Yamamura and Y Yoshinaga and W Wurst",

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Bradley, A, Anastassiadis, K, Ayadi, A, Battey, JF, Bell, C, Birling, MC, Bottomley, J, Brown, SD, Burger, A, Bult, CJ, Bushell, W, Collins, FS, Desaintes, C, Doe, B, Economides, A, Eppig, JT, Finnell, RH, D Fletcher, C, Fray, M, Frendewey, D, Friedel, RH, Grosveld, F, Hansen, J, Herault, Y, Hicks, G, Horlein, A, Houghton, R, de Angelis, MH, Huylebroeck, D, Iyer, V, de Jong, PJ, Kadin, JA, Kaloff, C, Kennedy, K, Koutsourakis, M, Lloyd, KCK, Marschall, S, Mason, J, McKerlie, C, McLeod, MP, von Melchner, H, Moore, M, Mujica, AO, Nagy, A, Nefedov, M, Nutter, LM, Pavlovic, G, Peterson, JL, Pollock, J, Ramirez-Solis, R, Rancourt, DE, Raspa, M, Remacle, JE, Ringwald, M, Rosen, B, Rosenthal, N, Rossant, J, Noppinger, PR, Ryder, E, Schick, JZ, Schnutgen, F, Schofield, P, Seisenberger, C, Selloum, M, Simpson, EM, Skarnes, WC, Smedley, D, Stanford, WL, Stewart, AF, Stone, K, Swan, K, Tadepally, H, Teboul, L, Tocchini-Valentini, GP, Valenzuela, D, West, AP, Yamamura, K, Yoshinaga, Y & Wurst, W 2012, 'The mammalian gene function resource: the international knockout mouse consortium', Mammalian Genome, vol. 23, no. 9-10, pp. 580-586. https://doi.org/10.1007/s00335-012-9422-2

TY - JOUR

T1 - The mammalian gene function resource: the international knockout mouse consortium

AU - Bradley, A

AU - Anastassiadis, K

AU - Ayadi, Azzeddine

AU - Battey, JF

AU - Bell, C

AU - Birling, MC

AU - Bottomley, J

AU - Brown, SD

AU - Burger, A

AU - Bult, CJ

AU - Bushell, W

AU - Collins, FS

AU - Desaintes, C

AU - Doe, B

AU - Economides, A

AU - Eppig, JT

AU - Finnell, RH

AU - D Fletcher, C

AU - Fray, M

AU - Frendewey, D

AU - Friedel, RH

AU - Grosveld, Frank

AU - Hansen, J

AU - Herault, Y

AU - Hicks, G

AU - Horlein, A

AU - Houghton, R

AU - de Angelis, MH

AU - Huylebroeck, Danny

AU - Iyer, V

AU - de Jong, PJ

AU - Kadin, JA

AU - Kaloff, C

AU - Kennedy, K

AU - Koutsourakis, M (Manousos)

AU - Lloyd, KCK

AU - Marschall, S

AU - Mason, J

AU - McKerlie, C

AU - McLeod, MP

AU - von Melchner, H

AU - Moore, M

AU - Mujica, AO

AU - Nagy, A

AU - Nefedov, M

AU - Nutter, LM

AU - Pavlovic, G

AU - Peterson, JL

AU - Pollock, J

AU - Ramirez-Solis, R

AU - Rancourt, DE

AU - Raspa, M

AU - Remacle, JE

AU - Ringwald, M

AU - Rosen, B

AU - Rosenthal, N

AU - Rossant, J

AU - Noppinger, PR

AU - Ryder, E

AU - Schick, JZ

AU - Schnutgen, F

AU - Schofield, P

AU - Seisenberger, C

AU - Selloum, M

AU - Simpson, EM

AU - Skarnes, WC

AU - Smedley, D

AU - Stanford, WL

AU - Stewart, AF

AU - Stone, K

AU - Swan, K

AU - Tadepally, H

AU - Teboul, L

AU - Tocchini-Valentini, GP

AU - Valenzuela, D

AU - West, AP

AU - Yamamura, K

AU - Yoshinaga, Y

AU - Wurst, W

PY - 2012

Y1 - 2012

N2 - In 2007, the International Knockout Mouse Consortium (IKMC) made the ambitious promise to generate mutations in virtually every protein-coding gene of the mouse genome in a concerted worldwide action. Now, 5 years later, the IKMC members have developed high-throughput gene trapping and, in particular, gene-targeting pipelines and generated more than 17,400 mutant murine embryonic stem (ES) cell clones and more than 1,700 mutant mouse strains, most of them conditional. A common IKMC web portal (www.knockoutmouse.org) has been established, allowing easy access to this unparalleled biological resource. The IKMC materials considerably enhance functional gene annotation of the mammalian genome and will have a major impact on future biomedical research.

AB - In 2007, the International Knockout Mouse Consortium (IKMC) made the ambitious promise to generate mutations in virtually every protein-coding gene of the mouse genome in a concerted worldwide action. Now, 5 years later, the IKMC members have developed high-throughput gene trapping and, in particular, gene-targeting pipelines and generated more than 17,400 mutant murine embryonic stem (ES) cell clones and more than 1,700 mutant mouse strains, most of them conditional. A common IKMC web portal (www.knockoutmouse.org) has been established, allowing easy access to this unparalleled biological resource. The IKMC materials considerably enhance functional gene annotation of the mammalian genome and will have a major impact on future biomedical research.

U2 - 10.1007/s00335-012-9422-2

DO - 10.1007/s00335-012-9422-2

M3 - Article

C2 - 22968824

SN - 0938-8990

VL - 23

SP - 580

EP - 586

JO - Mammalian Genome

JF - Mammalian Genome

IS - 9-10

ER -