The mast cell: A Janus in kidney transplants

G. van der Elst; H. Varol; M. Hermans; C. C. Baan; J. P. Duong-van Huyen; D. A. Hesselink; R. Kramann; M. Rabant; M. E.J. Reinders; J. H. von der Thüsen; T. P.P. van den Bosch; M. C. Clahsen-van Groningen

doi:10.3389/fimmu.2023.1122409

The mast cell: A Janus in kidney transplants

G. van der Elst, H. Varol, M. Hermans, C. C. Baan, J. P. Duong-van Huyen, D. A. Hesselink, R. Kramann, M. Rabant, M. E.J. Reinders, J. H. von der Thüsen, T. P.P. van den Bosch, M. C. Clahsen-van Groningen^*

^*Corresponding author for this work

Research output: Contribution to journal › Short survey › Academic › peer-review

3 Citations (Scopus)

29 Downloads (Pure)

Abstract

Mast cells (MCs) are innate immune cells with a versatile set of functionalities, enabling them to orchestrate immune responses in various ways. Aside from their known role in allergy, they also partake in both allograft tolerance and rejection through interaction with regulatory T cells, effector T cells, B cells and degranulation of cytokines and other mediators. MC mediators have both pro- and anti-inflammatory actions, but overall lean towards pro-fibrotic pathways. Paradoxically, they are also seen as having potential protective effects in tissue remodeling post-injury. This manuscript elaborates on current knowledge of the functional diversity of mast cells in kidney transplants, combining theory and practice into a MC model stipulating both protective and harmful capabilities in the kidney transplant setting.

Original language	English
Article number	1122409
Journal	Frontiers in Immunology
Volume	14
DOIs	https://doi.org/10.3389/fimmu.2023.1122409
Publication status	Published - 20 Feb 2023

Bibliographical note

Funding Information:
This article is funded by the dept. of Pathology, Erasmus Medical Center, Rotterdam, The Netherlands.

Publisher Copyright:
Copyright © 2023 van der Elst, Varol, Hermans, Baan, Duong-van Huyen, Hesselink, Kramann, Rabant, Reinders, von der Thüsen, van den Bosch and Clahsen-van Groningen.

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fimmu-14-1122409Final published version, 1.78 MBLicence: CC BY

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title = "The mast cell: A Janus in kidney transplants",

abstract = "Mast cells (MCs) are innate immune cells with a versatile set of functionalities, enabling them to orchestrate immune responses in various ways. Aside from their known role in allergy, they also partake in both allograft tolerance and rejection through interaction with regulatory T cells, effector T cells, B cells and degranulation of cytokines and other mediators. MC mediators have both pro- and anti-inflammatory actions, but overall lean towards pro-fibrotic pathways. Paradoxically, they are also seen as having potential protective effects in tissue remodeling post-injury. This manuscript elaborates on current knowledge of the functional diversity of mast cells in kidney transplants, combining theory and practice into a MC model stipulating both protective and harmful capabilities in the kidney transplant setting.",

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note = "Funding Information: This article is funded by the dept. of Pathology, Erasmus Medical Center, Rotterdam, The Netherlands. Publisher Copyright: Copyright {\textcopyright} 2023 van der Elst, Varol, Hermans, Baan, Duong-van Huyen, Hesselink, Kramann, Rabant, Reinders, von der Th{\"u}sen, van den Bosch and Clahsen-van Groningen.",

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AU - van der Elst, G.

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AU - Hermans, M.

AU - Baan, C. C.

AU - Duong-van Huyen, J. P.

AU - Hesselink, D. A.

AU - Kramann, R.

AU - Rabant, M.

AU - Reinders, M. E.J.

AU - von der Thüsen, J. H.

AU - van den Bosch, T. P.P.

AU - Clahsen-van Groningen, M. C.

N1 - Funding Information: This article is funded by the dept. of Pathology, Erasmus Medical Center, Rotterdam, The Netherlands. Publisher Copyright: Copyright © 2023 van der Elst, Varol, Hermans, Baan, Duong-van Huyen, Hesselink, Kramann, Rabant, Reinders, von der Thüsen, van den Bosch and Clahsen-van Groningen.

PY - 2023/2/20

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VL - 14

JO - Frontiers in Immunology

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The mast cell: A Janus in kidney transplants

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