TY - JOUR
T1 - The MO15 cell cycle kinase is associated with the TFIIH transcription-DNA repair factor
AU - Roy, Richard
AU - Adamczewski, Jörg P.
AU - Seroz, Thierry
AU - Vermeulen, Wim
AU - Tassan, Jean Pierre
AU - Schaeffer, Laurent
AU - Nigg, Erich A.
AU - Hoeijmakers, Jan H.J.
AU - Egly, Jean Marc
PY - 1994/12/16
Y1 - 1994/12/16
N2 - A protein kinase activity that phosphorylates the C-terminal domain (CTD) of RNA polymerase II and is associated with the basal transcription-repair factor TFIIH (also called BTF2) resides with MO15, a cyclin-dependent protein kinase that was first found to be involved in cell cycle regulation. Using in vivo and in vitro repair assays, we show that MO15 is important for nucleotide excision repair, most likely through its association with TFIIH, thus providing an unexpected link among three important cellular mechanisms.
AB - A protein kinase activity that phosphorylates the C-terminal domain (CTD) of RNA polymerase II and is associated with the basal transcription-repair factor TFIIH (also called BTF2) resides with MO15, a cyclin-dependent protein kinase that was first found to be involved in cell cycle regulation. Using in vivo and in vitro repair assays, we show that MO15 is important for nucleotide excision repair, most likely through its association with TFIIH, thus providing an unexpected link among three important cellular mechanisms.
UR - http://www.scopus.com/inward/record.url?scp=0028600051&partnerID=8YFLogxK
U2 - 10.1016/0092-8674(94)90039-6
DO - 10.1016/0092-8674(94)90039-6
M3 - Article
C2 - 8001135
AN - SCOPUS:0028600051
SN - 0092-8674
VL - 79
SP - 1093
EP - 1101
JO - Cell
JF - Cell
IS - 6
ER -