The multidimensional prognostic index as a measure of frailty in elderly patients with head and neck cancer

Ajay T. Bakas*, Aniel Sewnaik, Jaclyn van Straaten, Robert J.Baatenburg de Jong, Francesco U.S. Mattace-Raso, Harmke A. Polinder-Bos

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)
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Purpose: The multidimensional prognostic index (MPI) is a prognostic model derived from the comprehensive geriatric assessment (CGA) which can predict 1-year mortality risk in elderly individuals. We hypothesized that the MPI also reflects the degree of frailty and thus will correlate with established measures of frailty. Therefore, the aim of this study is to explore whether the MPI-score is a measure of frailty in older head and neck cancer patients and is associated with several physical functioning measurements. Patients and Methods: From November 2019 to July 2020, a prospective cohort study enrolled patients with head and neck cancer aged ≥70 years, and patients <70 years with an abnormal G8 score. The MPI-score ranged from 0 to 1 and was categorized in MPI-stage 1 (≤0.33, non-frail); MPI-stage 2 (0.34–0.66, mildly frail), and MPI-stage 3 (≥0.67, severe frail). Pearson’s correlation coefficient and multivariable linear regression were used to study the association between MPI-score and the physical functioning measurements handgrip strength, gait speed, and the timed up and go test (TUGT). Results: A total of 163 patients were included. One hundred four (63.8%) patients were categorized as non-frail according MPI-stage 1, and 59 (36.2%) patients as mildly or severe frail (n=55 MPI-stage 2; n=4 MPI-stage 3, respectively). A higher MPI-score was significantly associated with lower hand grip strength (B −0.49 [95% CI −0.71; −0.28] p<0.001), lower gait speed (B −0.41 [95% CI −0.55; −0.25] p<0.001), and a slower TUGT (B 0.53 [95% CI 0.66; 0.85] p<0.001). Conclusion: Almost one-third of the included patients with head and neck cancer was mild or severe frail. A higher MPI-score, indicating higher degree of frailty, was associated with worse physical performance by lower handgrip strength, gait speed, and a slower TUGT. Thus, the MPI reflects the degree of frailty.

Original languageEnglish
Pages (from-to)1679-1689
Number of pages11
JournalClinical Interventions in Aging
Publication statusPublished - 8 Sept 2021

Bibliographical note

Funding Information:
We would like to thank all volunteers from the departments of Otorhinolaryngology and Oral and Maxillofacial surgery, and nurse consultants, former research students, and residents of the Division of Geriatrics at the Erasmus MC University Medical Center for their contribution to the study database.

Publisher Copyright:
© 2021 Bakas et al.


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