The mysteries of target site concentrations of antibiotics in bone and joint infections: what is known? A narrative review

Birgit C. P. Koch*, Qiaolin Zhao, Maartje Oosterhoff, Jakob van Oldenrijk, Alan Abdulla, Brenda C. M. de Winter, Koen Bos, Anouk E. Muller

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

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Abstract

Introduction Currently, antibiotic treatment is often a standard dosing regimen in bone and joint infections (BJI). However, it remains unknown if exposure at the target-site is adequate. The aim of this review is to gain more insight in the relationship between the target site concentration of antibiotic and the minimal inhibitory concentration to target the bacteria in bone and joint infections (BJI). Areas covered A literature search was performed by Erasmus MC Medical library. Bone, bone tissue and synovial concentration of antibiotics were covered in humans. In addition, we reported number of patients, dose, sampling method, analytical method and tissue and plasma concentrations. We used the epidemiological cutoff value (ECOFF) values of the targeted micro-organisms. If more than 3 publications were available on the antibiotic, we graphically presented ECOFFS values against reported antibiotic concentrations. Expert opinion For most antibiotics, the literature is sparse. In addition, a lot of variable and total antibiotic concentrations are published. Ciprofloxacin, cefazolin, cefuroxime, vancomycin and linezolid seem to have adequate average exposure if correlating total concentration to ECOFF, when standard dosing is used. With regard to other antibiotics, results are inconclusive. More extensive pharmacokinetic/pharmacodynamic modeling in BJI is needed.

Original languageEnglish
Pages (from-to)587-600
Number of pages14
JournalExpert Opinion on Drug Metabolism & Toxicology
Volume18
Issue number9
DOIs
Publication statusE-pub ahead of print - 4 Sep 2022

Bibliographical note

Funding Information:
This paper was not funded.

Publisher Copyright:
© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

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