The neuropathogenesis of highly pathogenic avian influenza H5Nx viruses in mammalian species including humans

Lisa Bauer; Feline F.W. Benavides; Edwin J.B. Veldhuis Kroeze; Emmie de Wit; Debby van Riel

doi:10.1016/j.tins.2023.08.002

The neuropathogenesis of highly pathogenic avian influenza H5Nx viruses in mammalian species including humans

Lisa Bauer, Feline F.W. Benavides, Edwin J.B. Veldhuis Kroeze, Emmie de Wit, Debby van Riel^*

^*Corresponding author for this work

Virology

Research output: Contribution to journal › Review article › Academic › peer-review

8 Citations (Scopus)

38 Downloads (Pure)

Abstract

Circulation of highly pathogenic avian influenza (HPAI) H5Nx viruses of the A/Goose/Guangdong/1/96 lineage in birds regularly causes infections of mammals, including humans. In many mammalian species, infections are associated with severe neurological disease, a unique feature of HPAI H5Nx viruses compared with other influenza A viruses. Here, we provide an overview of the neuropathogenesis of HPAI H5Nx virus infection in mammals, centered on three aspects: neuroinvasion, neurotropism, and neurovirulence. We focus on in vitro studies, as well as studies on naturally or experimentally infected mammals. Additionally, we discuss the contribution of viral factors to the neuropathogenesis of HPAI H5Nx virus infections and the efficacy of intervention strategies to prevent neuroinvasion or the development of neurological disease.

Original language	English
Pages (from-to)	953-970
Number of pages	18
Journal	Trends in Neurosciences
Volume	46
Issue number	11
DOIs	https://doi.org/10.1016/j.tins.2023.08.002
Publication status	Published - Nov 2023

Bibliographical note

Funding Information:
L.B. is supported by The Netherlands Organization for Scientific Research (XS contract number OCENW.XS22.2.045) and by grant 2023 from the European Society of Clinical Microbiology and Infectious Diseases (Europäische Gesellschaft für klinische Mikrobiologie und Infektionskrankheiten) (ESCMID). E.d.W. is supported by the Intramural Research Program of NIAID, NIH. D.v.R. is supported by fellowships from The Netherlands Organization for Scientific Research (VIDI contract 91718308) and the European Union's Horizon Europe FARM2FORK research and innovation program Kappa Flu grant number 101084171. The authors declare no competing interests.

Publisher Copyright:
© 2023 The Authors

Access to Document

10.1016/j.tins.2023.08.002Licence: CC BY

The neuropathogenesis of highly pathogenic avian influenza H5Nx viruses in mammalian species including humansProof, 1.33 MBLicence: CC BY

Cite this

@article{d014d73b08bf4fe9b21cd8b781c1339a,

title = "The neuropathogenesis of highly pathogenic avian influenza H5Nx viruses in mammalian species including humans",

abstract = "Circulation of highly pathogenic avian influenza (HPAI) H5Nx viruses of the A/Goose/Guangdong/1/96 lineage in birds regularly causes infections of mammals, including humans. In many mammalian species, infections are associated with severe neurological disease, a unique feature of HPAI H5Nx viruses compared with other influenza A viruses. Here, we provide an overview of the neuropathogenesis of HPAI H5Nx virus infection in mammals, centered on three aspects: neuroinvasion, neurotropism, and neurovirulence. We focus on in vitro studies, as well as studies on naturally or experimentally infected mammals. Additionally, we discuss the contribution of viral factors to the neuropathogenesis of HPAI H5Nx virus infections and the efficacy of intervention strategies to prevent neuroinvasion or the development of neurological disease.",

author = "Lisa Bauer and Benavides, {Feline F.W.} and {Veldhuis Kroeze}, {Edwin J.B.} and {de Wit}, Emmie and {van Riel}, Debby",

note = "Funding Information: L.B. is supported by The Netherlands Organization for Scientific Research (XS contract number OCENW.XS22.2.045) and by grant 2023 from the European Society of Clinical Microbiology and Infectious Diseases (Europ{\"a}ische Gesellschaft f{\"u}r klinische Mikrobiologie und Infektionskrankheiten) (ESCMID). E.d.W. is supported by the Intramural Research Program of NIAID, NIH. D.v.R. is supported by fellowships from The Netherlands Organization for Scientific Research (VIDI contract 91718308) and the European Union's Horizon Europe FARM2FORK research and innovation program Kappa Flu grant number 101084171. The authors declare no competing interests. Publisher Copyright: {\textcopyright} 2023 The Authors",

year = "2023",

month = nov,

doi = "10.1016/j.tins.2023.08.002",

language = "English",

volume = "46",

pages = "953--970",

journal = "Trends in Neurosciences",

issn = "0166-2236",

publisher = "Elsevier Ltd.",

number = "11",

}

TY - JOUR

T1 - The neuropathogenesis of highly pathogenic avian influenza H5Nx viruses in mammalian species including humans

AU - Bauer, Lisa

AU - Benavides, Feline F.W.

AU - Veldhuis Kroeze, Edwin J.B.

AU - de Wit, Emmie

AU - van Riel, Debby

N1 - Funding Information: L.B. is supported by The Netherlands Organization for Scientific Research (XS contract number OCENW.XS22.2.045) and by grant 2023 from the European Society of Clinical Microbiology and Infectious Diseases (Europäische Gesellschaft für klinische Mikrobiologie und Infektionskrankheiten) (ESCMID). E.d.W. is supported by the Intramural Research Program of NIAID, NIH. D.v.R. is supported by fellowships from The Netherlands Organization for Scientific Research (VIDI contract 91718308) and the European Union's Horizon Europe FARM2FORK research and innovation program Kappa Flu grant number 101084171. The authors declare no competing interests. Publisher Copyright: © 2023 The Authors

PY - 2023/11

Y1 - 2023/11

N2 - Circulation of highly pathogenic avian influenza (HPAI) H5Nx viruses of the A/Goose/Guangdong/1/96 lineage in birds regularly causes infections of mammals, including humans. In many mammalian species, infections are associated with severe neurological disease, a unique feature of HPAI H5Nx viruses compared with other influenza A viruses. Here, we provide an overview of the neuropathogenesis of HPAI H5Nx virus infection in mammals, centered on three aspects: neuroinvasion, neurotropism, and neurovirulence. We focus on in vitro studies, as well as studies on naturally or experimentally infected mammals. Additionally, we discuss the contribution of viral factors to the neuropathogenesis of HPAI H5Nx virus infections and the efficacy of intervention strategies to prevent neuroinvasion or the development of neurological disease.

AB - Circulation of highly pathogenic avian influenza (HPAI) H5Nx viruses of the A/Goose/Guangdong/1/96 lineage in birds regularly causes infections of mammals, including humans. In many mammalian species, infections are associated with severe neurological disease, a unique feature of HPAI H5Nx viruses compared with other influenza A viruses. Here, we provide an overview of the neuropathogenesis of HPAI H5Nx virus infection in mammals, centered on three aspects: neuroinvasion, neurotropism, and neurovirulence. We focus on in vitro studies, as well as studies on naturally or experimentally infected mammals. Additionally, we discuss the contribution of viral factors to the neuropathogenesis of HPAI H5Nx virus infections and the efficacy of intervention strategies to prevent neuroinvasion or the development of neurological disease.

UR - http://www.scopus.com/inward/record.url?scp=85169888814&partnerID=8YFLogxK

U2 - 10.1016/j.tins.2023.08.002

DO - 10.1016/j.tins.2023.08.002

M3 - Review article

C2 - 37684136

AN - SCOPUS:85169888814

SN - 0166-2236

VL - 46

SP - 953

EP - 970

JO - Trends in Neurosciences

JF - Trends in Neurosciences

IS - 11

ER -

The neuropathogenesis of highly pathogenic avian influenza H5Nx viruses in mammalian species including humans

Abstract

Bibliographical note

Access to Document

Other files and links

Fingerprint

Cite this