The outcome of bifurcation lesion stenting using a biolimus-eluting stent with a bio-degradable polymer compared to a sirolimus-eluting stent with a durable polymer

Scot Garg, Joanna Wykrzykowska, PWJC (Patrick) Serruys, T (Ton) de Vries, P Buszman, S Trznadel, A Linke, K Lenk, T Ischinger, V Klauss, F Eberli, R Corti, W (William) Wijns, MC Morice, C (Carlo) di Mario, P Tyczynski, Robert Jan van Geuns, P Eerdmans, Gerrit-anne Es, B MeierP Juni, S Windecker

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Abstract

Aims: This study investigated the differences in clinical outcomes between patients with bifurcation lesions (BL) treated with a biolimus-eluting stent (BES) with a biodegradable polymer, and a sirolimus-eluting stent (SES) with a durable polymer. Methods and results: The clinical outcomes were assessed in the 497 patients (BES 258, SES 239) enrolled in the multicentre, randomised LEADERS trial who underwent treatment of >= 1 BL (total=534 BL). At 12-months follow-up there was no significant difference in the primary endpoint of MACE, a composite of cardiac death, myocardial infarction and clinically indicated target vessel revascularisation (BES 12.8% vs. SES 16.3%, p=0.31). Patients treated with BES had comparable rates of cardiac death (BES 2.7% vs. SES 2.9%, p=1.00), numerically higher rates of myocardial infarction (BES 8.9% vs. SES 5.4%, p=0.17), and significantly lower rates of clinically indicated target vessel revascularisation (4.3% vs. 11.3%, p=0.004) when compared to those treated with SES. The rate of stent thrombosis at 12-months was 4.3% and 3.8% for BES and SES, respectively (p=0.82). Conclusions: In the treatment of BL the use of BES lead to superior efficacy and comparable safety compared to SES.
Original languageUndefined/Unknown
Pages (from-to)928-935
Number of pages8
JournalEuroIntervention
Volume6
Issue number8
DOIs
Publication statusPublished - 2011

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