The Papain Inhibitor (SPI) of Streptomyces mobaraensis Inhibits Bacterial Cysteine Proteases and Is an Antagonist of Bacterial Growth

S Zindel, Wendy Kaman, S Frols, F Pfeifer, A Peters, John Hays, HL Fuchsbauer

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11 Citations (Scopus)

Abstract

A novel papain inhibitory protein (SPI) from Streptomyces mobaraensis was studied to measure its inhibitory effect on bacterial cysteine protease activity (Staphylococcus aureus SspB) and culture supernatants (Porphyromonas gingivalis, Bacillus anthracis). Further, growth of Bacillus anthracis, Staphylococcus aureus, Pseudomonas aeruginosa, and Vibrio cholerae was completely inhibited by 10 mu M SPI. At this concentration of SPI, no cytotoxicity was observed. We conclude that SPI inhibits bacterial virulence factors and has the potential to become a novel therapeutic treatment against a range of unrelated pathogenic bacteria.
Original languageUndefined/Unknown
Pages (from-to)3388-3391
Number of pages4
JournalAntimicrobial Agents & Chemotherapy
Volume57
Issue number7
DOIs
Publication statusPublished - 2013

Research programs

  • EMC MM-04-28-01

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