The Pharmacogenetics of Calcineurin Inhibitor-Related Nephrotoxicity

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Chronic calcineurin inhibitor (CNI)-induced nephrotoxicity is associated with prolonged use of cyclosporine and tacrolimus and has been observed after all types of transplantation, as well as during treatment of autoimmune disease. Extensive alterations in the renal architecture including glomerular sclerosis, tubular atrophy and interstitial fibrosis may lead to end-stage renal failure. Increasing evidence shows that pharmacogenetic factors explain part of the between-patient differences in susceptibility to developing CNI-induced nephrotoxicity. In this paper this evidence is reviewed, with special emphasis on the role of genetic factors influencing metabolism and transportation of CNIs in both acceptor and donor.
Original languageUndefined/Unknown
Pages (from-to)387-393
Number of pages7
JournalTherapeutic Drug Monitoring
Issue number4
Publication statusPublished - 2010

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