TY - CHAP
T1 - The Polycystic Ovary Syndrome (PCOS)
AU - Louwers, Yvonne V.
AU - Laven, Joop S.E.
N1 - Publisher Copyright: © 2020, Springer Nature Switzerland AG.
PY - 2020/5
Y1 - 2020/5
N2 - PCOS is the commonest endocrine abnormality in women of reproductive age. It represents the major cause of anovulatory infertility and is also associated with hirsutism and acne. The typical biochemical features are elevated serum levels of testosterone and luteinizing hormone (LH) along with metabolic disturbances including insulin resistance and abnormalities of energy expenditure. PCOS is now recognized as a major risk factor for the development of type 2 diabetes (T2DM) and cardiovascular disease in later life. At least in part, this reflects the strong associations between PCOS and obesity, with the latter being an amplifier of PCOS. The etiology of PCOS is unclear, and it seems to be a complex disease resulting from a complex interplay between genetic and environmental factors. Moreover, there is evidence for familial clustering of endocrine and metabolic features of PCOS. Environmental factors such as diet and obesity might similarly contribute to the phenotype. Due to its heterogeneous nature, there have been historical disagreements about the definitions and how to diagnose PCOS. Treatment should be tailored to the complaints and needs of the patient and involve restoring fertility, treatment of metabolic complaints, treatment of androgen excess, and providing endometrial protection. The complexity of the disorder, and the impact on quality of life, requires timely diagnosis, screening for complications, and management strategies of the long-term health issues associated with PCOS. The syndrome remains underdiagnosed, and women experience significant delays to diagnosis.
AB - PCOS is the commonest endocrine abnormality in women of reproductive age. It represents the major cause of anovulatory infertility and is also associated with hirsutism and acne. The typical biochemical features are elevated serum levels of testosterone and luteinizing hormone (LH) along with metabolic disturbances including insulin resistance and abnormalities of energy expenditure. PCOS is now recognized as a major risk factor for the development of type 2 diabetes (T2DM) and cardiovascular disease in later life. At least in part, this reflects the strong associations between PCOS and obesity, with the latter being an amplifier of PCOS. The etiology of PCOS is unclear, and it seems to be a complex disease resulting from a complex interplay between genetic and environmental factors. Moreover, there is evidence for familial clustering of endocrine and metabolic features of PCOS. Environmental factors such as diet and obesity might similarly contribute to the phenotype. Due to its heterogeneous nature, there have been historical disagreements about the definitions and how to diagnose PCOS. Treatment should be tailored to the complaints and needs of the patient and involve restoring fertility, treatment of metabolic complaints, treatment of androgen excess, and providing endometrial protection. The complexity of the disorder, and the impact on quality of life, requires timely diagnosis, screening for complications, and management strategies of the long-term health issues associated with PCOS. The syndrome remains underdiagnosed, and women experience significant delays to diagnosis.
UR - http://www.scopus.com/inward/record.url?scp=85164765015&partnerID=8YFLogxK
U2 - 10.1007/978-3-030-03594-5_3-1
DO - 10.1007/978-3-030-03594-5_3-1
M3 - Chapter
C2 - 32150694
AN - SCOPUS:85102596898
SN - 978-3-030-14781-5
T3 - Endocrinology (Switzerland)
SP - 39
EP - 61
BT - Female Reproductive Dysfunction
PB - Springer Science+Business Media
ER -
