The Potential of Metabolomic Analyses as Predictive Biomarkers of Preterm Delivery: A Systematic Review

Emma Ronde; Irwin K.M. Reiss; Thomas Hankemeier; Tim G. De Meij; Nina Frerichs; Sam Schoenmakers

doi:10.3389/fendo.2021.668417

The Potential of Metabolomic Analyses as Predictive Biomarkers of Preterm Delivery: A Systematic Review

Emma Ronde^*, Irwin K.M. Reiss, Thomas Hankemeier, Tim G. De Meij, Nina Frerichs, Sam Schoenmakers

^*Corresponding author for this work

Research output: Contribution to journal › Review article › Academic › peer-review

3 Citations (Scopus)

30 Downloads (Pure)

Abstract

Scope: as the leading cause of perinatal mortality and morbidity worldwide, the impact of premature delivery is undisputable. Thus far, non-invasive, cost-efficient and accurate biochemical markers to predict preterm delivery are scarce. The aim of this systematic review is to investigate the potential of non-invasive metabolomic biomarkers for the prediction of preterm delivery. Methods and Results: Databases were systematically searched from March 2019 up to May 2020 resulting in 4062 articles, of which 45 were retrieved for full-text assessment. The resulting metabolites used for further analyses, such as ferritin, prostaglandin and different vitamins were obtained from different human anatomical compartments or sources (vaginal fluid, serum, urine and umbilical cord) and compared between groups of women with preterm and term delivery. None of the reported metabolites showed uniform results, however, a combination of metabolomics biomarkers may have potential to predict preterm delivery and need to be evaluated in future studies.

Original language	English
Article number	668417
Journal	Frontiers in Endocrinology
Volume	12
DOIs	https://doi.org/10.3389/fendo.2021.668417
Publication status	Published - 6 Sep 2021

Bibliographical note

Funding Information:
The authors thank Wichor M. Bramer, biomedical information specialist, Erasmus MC Rotterdam, The Netherlands, for his help in the systematic search and assessment of literature

Publisher Copyright:
© Copyright © 2021 Ronde, Reiss, Hankemeier, De Meij, Frerichs and Schoenmakers.

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The Potential of Metabolomic Analyses as Predictive Biomarkers of Preterm DeliveryFinal published version, 2.92 MBLicence: CC BY

Cite this

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title = "The Potential of Metabolomic Analyses as Predictive Biomarkers of Preterm Delivery: A Systematic Review",

abstract = "Scope: as the leading cause of perinatal mortality and morbidity worldwide, the impact of premature delivery is undisputable. Thus far, non-invasive, cost-efficient and accurate biochemical markers to predict preterm delivery are scarce. The aim of this systematic review is to investigate the potential of non-invasive metabolomic biomarkers for the prediction of preterm delivery. Methods and Results: Databases were systematically searched from March 2019 up to May 2020 resulting in 4062 articles, of which 45 were retrieved for full-text assessment. The resulting metabolites used for further analyses, such as ferritin, prostaglandin and different vitamins were obtained from different human anatomical compartments or sources (vaginal fluid, serum, urine and umbilical cord) and compared between groups of women with preterm and term delivery. None of the reported metabolites showed uniform results, however, a combination of metabolomics biomarkers may have potential to predict preterm delivery and need to be evaluated in future studies.",

author = "Emma Ronde and Reiss, {Irwin K.M.} and Thomas Hankemeier and {De Meij}, {Tim G.} and Nina Frerichs and Sam Schoenmakers",

note = "Funding Information: The authors thank Wichor M. Bramer, biomedical information specialist, Erasmus MC Rotterdam, The Netherlands, for his help in the systematic search and assessment of literature Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2021 Ronde, Reiss, Hankemeier, De Meij, Frerichs and Schoenmakers.",

year = "2021",

month = sep,

day = "6",

doi = "10.3389/fendo.2021.668417",

language = "English",

volume = "12",

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T1 - The Potential of Metabolomic Analyses as Predictive Biomarkers of Preterm Delivery

T2 - A Systematic Review

AU - Ronde, Emma

AU - Reiss, Irwin K.M.

AU - Hankemeier, Thomas

AU - De Meij, Tim G.

AU - Frerichs, Nina

AU - Schoenmakers, Sam

N1 - Funding Information: The authors thank Wichor M. Bramer, biomedical information specialist, Erasmus MC Rotterdam, The Netherlands, for his help in the systematic search and assessment of literature Publisher Copyright: © Copyright © 2021 Ronde, Reiss, Hankemeier, De Meij, Frerichs and Schoenmakers.

PY - 2021/9/6

Y1 - 2021/9/6

N2 - Scope: as the leading cause of perinatal mortality and morbidity worldwide, the impact of premature delivery is undisputable. Thus far, non-invasive, cost-efficient and accurate biochemical markers to predict preterm delivery are scarce. The aim of this systematic review is to investigate the potential of non-invasive metabolomic biomarkers for the prediction of preterm delivery. Methods and Results: Databases were systematically searched from March 2019 up to May 2020 resulting in 4062 articles, of which 45 were retrieved for full-text assessment. The resulting metabolites used for further analyses, such as ferritin, prostaglandin and different vitamins were obtained from different human anatomical compartments or sources (vaginal fluid, serum, urine and umbilical cord) and compared between groups of women with preterm and term delivery. None of the reported metabolites showed uniform results, however, a combination of metabolomics biomarkers may have potential to predict preterm delivery and need to be evaluated in future studies.

AB - Scope: as the leading cause of perinatal mortality and morbidity worldwide, the impact of premature delivery is undisputable. Thus far, non-invasive, cost-efficient and accurate biochemical markers to predict preterm delivery are scarce. The aim of this systematic review is to investigate the potential of non-invasive metabolomic biomarkers for the prediction of preterm delivery. Methods and Results: Databases were systematically searched from March 2019 up to May 2020 resulting in 4062 articles, of which 45 were retrieved for full-text assessment. The resulting metabolites used for further analyses, such as ferritin, prostaglandin and different vitamins were obtained from different human anatomical compartments or sources (vaginal fluid, serum, urine and umbilical cord) and compared between groups of women with preterm and term delivery. None of the reported metabolites showed uniform results, however, a combination of metabolomics biomarkers may have potential to predict preterm delivery and need to be evaluated in future studies.

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DO - 10.3389/fendo.2021.668417

M3 - Review article

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JO - Frontiers in Endocrinology

JF - Frontiers in Endocrinology

SN - 1664-2392

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The Potential of Metabolomic Analyses as Predictive Biomarkers of Preterm Delivery: A Systematic Review

Abstract

Bibliographical note

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