The POU factor Oct-6 and Schwann cell differentiation

Martine Jaegle, Wim Mandemakers, Ludo Broos, Ronald Zwart, Alar Karis, Pim Visser, Frank Grosveld, Dies Meijer*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

244 Citations (Scopus)

Abstract

The POU transcription factor Oct-6, also known as SCIP or Tst-1, has been implicated as a major transcriptional regulator in Schwann cell differentiation. Microscopic and immunochemical analysis of sciatic nerves of Oct-6 mice at different stages of postnatal development reveals a delay in Schwann cell differentiation, with a transient arrest at the promyelination stage. Thus, Oct-6 appears to be required for the transition of promyelin cells to myelinating cells. Once these cells progress past this point, Oct-6 is no longer required, and myelination occurs normally.

Original languageEnglish
Pages (from-to)507-510
Number of pages4
JournalScience
Volume273
Issue number5274
DOIs
Publication statusPublished - 26 Jul 1996

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