The POU factor Oct-6 and Schwann cell differentiation

Martine Jaegle; Wim Mandemakers; Ludo Broos; Ronald Zwart; Alar Karis; Pim Visser; Frank Grosveld; Dies Meijer

doi:10.1126/science.273.5274.507

The POU factor Oct-6 and Schwann cell differentiation

Martine Jaegle, Wim Mandemakers, Ludo Broos, Ronald Zwart, Alar Karis, Pim Visser, Frank Grosveld, Dies Meijer^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

247 Citations (Scopus)

Abstract

The POU transcription factor Oct-6, also known as SCIP or Tst-1, has been implicated as a major transcriptional regulator in Schwann cell differentiation. Microscopic and immunochemical analysis of sciatic nerves of Oct-6 mice at different stages of postnatal development reveals a delay in Schwann cell differentiation, with a transient arrest at the promyelination stage. Thus, Oct-6 appears to be required for the transition of promyelin cells to myelinating cells. Once these cells progress past this point, Oct-6 is no longer required, and myelination occurs normally.

Original language	English
Pages (from-to)	507-510
Number of pages	4
Journal	Science
Volume	273
Issue number	5274
DOIs	https://doi.org/10.1126/science.273.5274.507
Publication status	Published - 26 Jul 1996

Access to Document

10.1126/science.273.5274.507

Cite this

@article{9a8228f3cb95442b809163eac00ea6d8,

title = "The POU factor Oct-6 and Schwann cell differentiation",

abstract = "The POU transcription factor Oct-6, also known as SCIP or Tst-1, has been implicated as a major transcriptional regulator in Schwann cell differentiation. Microscopic and immunochemical analysis of sciatic nerves of Oct-6 mice at different stages of postnatal development reveals a delay in Schwann cell differentiation, with a transient arrest at the promyelination stage. Thus, Oct-6 appears to be required for the transition of promyelin cells to myelinating cells. Once these cells progress past this point, Oct-6 is no longer required, and myelination occurs normally.",

author = "Martine Jaegle and Wim Mandemakers and Ludo Broos and Ronald Zwart and Alar Karis and Pim Visser and Frank Grosveld and Dies Meijer",

year = "1996",

month = jul,

day = "26",

doi = "10.1126/science.273.5274.507",

language = "English",

volume = "273",

pages = "507--510",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "5274",

}

TY - JOUR

T1 - The POU factor Oct-6 and Schwann cell differentiation

AU - Jaegle, Martine

AU - Mandemakers, Wim

AU - Broos, Ludo

AU - Zwart, Ronald

AU - Karis, Alar

AU - Visser, Pim

AU - Grosveld, Frank

AU - Meijer, Dies

PY - 1996/7/26

Y1 - 1996/7/26

N2 - The POU transcription factor Oct-6, also known as SCIP or Tst-1, has been implicated as a major transcriptional regulator in Schwann cell differentiation. Microscopic and immunochemical analysis of sciatic nerves of Oct-6 mice at different stages of postnatal development reveals a delay in Schwann cell differentiation, with a transient arrest at the promyelination stage. Thus, Oct-6 appears to be required for the transition of promyelin cells to myelinating cells. Once these cells progress past this point, Oct-6 is no longer required, and myelination occurs normally.

AB - The POU transcription factor Oct-6, also known as SCIP or Tst-1, has been implicated as a major transcriptional regulator in Schwann cell differentiation. Microscopic and immunochemical analysis of sciatic nerves of Oct-6 mice at different stages of postnatal development reveals a delay in Schwann cell differentiation, with a transient arrest at the promyelination stage. Thus, Oct-6 appears to be required for the transition of promyelin cells to myelinating cells. Once these cells progress past this point, Oct-6 is no longer required, and myelination occurs normally.

UR - http://www.scopus.com/inward/record.url?scp=0029795302&partnerID=8YFLogxK

U2 - 10.1126/science.273.5274.507

DO - 10.1126/science.273.5274.507

M3 - Article

C2 - 8662541

AN - SCOPUS:0029795302

SN - 0036-8075

VL - 273

SP - 507

EP - 510

JO - Science

JF - Science

IS - 5274

ER -

The POU factor Oct-6 and Schwann cell differentiation

Abstract

Access to Document

Other files and links

Fingerprint

Cite this