The POU factor Oct-6 and Schwann cell differentiation

Martine Jaegle; Wim Mandemakers; Ludo Broos; Ronald Zwart; Alar Karis; Pim Visser; Frank Grosveld; Dies Meijer

doi:10.1126/science.273.5274.507

The POU factor Oct-6 and Schwann cell differentiation

Martine Jaegle
, Wim Mandemakers
, Ludo Broos
, Ronald Zwart
, Alar Karis
, Pim Visser
, Frank Grosveld
, Dies Meijer^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

255 Citations (Scopus)

Abstract

The POU transcription factor Oct-6, also known as SCIP or Tst-1, has been implicated as a major transcriptional regulator in Schwann cell differentiation. Microscopic and immunochemical analysis of sciatic nerves of Oct-6 mice at different stages of postnatal development reveals a delay in Schwann cell differentiation, with a transient arrest at the promyelination stage. Thus, Oct-6 appears to be required for the transition of promyelin cells to myelinating cells. Once these cells progress past this point, Oct-6 is no longer required, and myelination occurs normally.

Original language	English
Pages (from-to)	507-510
Number of pages	4
Journal	Science
Volume	273
Issue number	5274
DOIs	https://doi.org/10.1126/science.273.5274.507
Publication status	Published - 26 Jul 1996

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abstract = "The POU transcription factor Oct-6, also known as SCIP or Tst-1, has been implicated as a major transcriptional regulator in Schwann cell differentiation. Microscopic and immunochemical analysis of sciatic nerves of Oct-6 mice at different stages of postnatal development reveals a delay in Schwann cell differentiation, with a transient arrest at the promyelination stage. Thus, Oct-6 appears to be required for the transition of promyelin cells to myelinating cells. Once these cells progress past this point, Oct-6 is no longer required, and myelination occurs normally.",

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AU - Jaegle, Martine

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AU - Broos, Ludo

AU - Zwart, Ronald

AU - Karis, Alar

AU - Visser, Pim

AU - Grosveld, Frank

AU - Meijer, Dies

PY - 1996/7/26

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N2 - The POU transcription factor Oct-6, also known as SCIP or Tst-1, has been implicated as a major transcriptional regulator in Schwann cell differentiation. Microscopic and immunochemical analysis of sciatic nerves of Oct-6 mice at different stages of postnatal development reveals a delay in Schwann cell differentiation, with a transient arrest at the promyelination stage. Thus, Oct-6 appears to be required for the transition of promyelin cells to myelinating cells. Once these cells progress past this point, Oct-6 is no longer required, and myelination occurs normally.

AB - The POU transcription factor Oct-6, also known as SCIP or Tst-1, has been implicated as a major transcriptional regulator in Schwann cell differentiation. Microscopic and immunochemical analysis of sciatic nerves of Oct-6 mice at different stages of postnatal development reveals a delay in Schwann cell differentiation, with a transient arrest at the promyelination stage. Thus, Oct-6 appears to be required for the transition of promyelin cells to myelinating cells. Once these cells progress past this point, Oct-6 is no longer required, and myelination occurs normally.

UR - https://www.scopus.com/pages/publications/0029795302

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The POU factor Oct-6 and Schwann cell differentiation

Abstract

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