Abstract
The best independent predictors of survival after AIDS diagnosis were determined in 160 homosexual men from the Amsterdam Cohort Study (1987 CDC case definition). In a Cox model, all pre-AIDS laboratory markers gathered during follow-up in the study did not independently predict survival after AIDS. A second analysis, using data available only at AIDS diagnosis, revealed that T cell reactivity after stimulation with phytohemagglutinin and monoclonal CD3 antibodies and the CD4+ cell count at diagnosis were independent predictors of survival. In an interval-based Cox model, the predictive value of pre-AIDS zidovudine use was determined. One year after AIDS diagnosis, participants with pre-AIDS zidovudine use had a worse survival probability (relative hazard = 3.99). In conclusion, the survival probability of homosexual men with AIDS can be estimated adequately using information obtained at clinical AIDS diagnosis. Analysis revealed the important predictive value of T cell function tests in vitro.
| Original language | English |
|---|---|
| Pages (from-to) | 97-104 |
| Number of pages | 8 |
| Journal | Journal of Infectious Diseases |
| Volume | 172 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jul 1995 |
| Externally published | Yes |
Bibliographical note
Funding Information:Received 1 November 1994; revised 7 March 1995. Grant support: Netherlands Foundation for Preventive Medicine and Advisory Council on Health Research, Program Committee for AIDS Research (28-2370 and 118775). Reprints or correspondence: Dr. Patrick J. E. Bindels, Dept. of Public Health, Nieuwe Achtergracht 100, P.O. Box 20244, 1000 HE Amsterdam, Netherlands.
