The predictive value of t cell function in vitro and pre-AIDS zidovudine use for survival after aids diagnosis in a cohort of homosexual men in Amsterdam

Patrick J.E. Bindels; Anneke Krol; Marijke Roos; Jan Veenstra; Johanna A.R. Van den Hoek; Frank Miedema; Roel A. Coutinho

doi:10.1093/infdis/172.1.97

The predictive value of t cell function in vitro and pre-AIDS zidovudine use for survival after aids diagnosis in a cohort of homosexual men in Amsterdam

Patrick J.E. Bindels^*
, Anneke Krol
, Marijke Roos
, Jan Veenstra
, Johanna A.R. Van den Hoek
, Frank Miedema
, Roel A. Coutinho

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

14 Citations (Scopus)

Abstract

The best independent predictors of survival after AIDS diagnosis were determined in 160 homosexual men from the Amsterdam Cohort Study (1987 CDC case definition). In a Cox model, all pre-AIDS laboratory markers gathered during follow-up in the study did not independently predict survival after AIDS. A second analysis, using data available only at AIDS diagnosis, revealed that T cell reactivity after stimulation with phytohemagglutinin and monoclonal CD3 antibodies and the CD4⁺ cell count at diagnosis were independent predictors of survival. In an interval-based Cox model, the predictive value of pre-AIDS zidovudine use was determined. One year after AIDS diagnosis, participants with pre-AIDS zidovudine use had a worse survival probability (relative hazard = 3.99). In conclusion, the survival probability of homosexual men with AIDS can be estimated adequately using information obtained at clinical AIDS diagnosis. Analysis revealed the important predictive value of T cell function tests in vitro.

Original language	English
Pages (from-to)	97-104
Number of pages	8
Journal	Journal of Infectious Diseases
Volume	172
Issue number	1
DOIs	https://doi.org/10.1093/infdis/172.1.97
Publication status	Published - Jul 1995
Externally published	Yes

Bibliographical note

Funding Information:
Received 1 November 1994; revised 7 March 1995. Grant support: Netherlands Foundation for Preventive Medicine and Advisory Council on Health Research, Program Committee for AIDS Research (28-2370 and 118775). Reprints or correspondence: Dr. Patrick J. E. Bindels, Dept. of Public Health, Nieuwe Achtergracht 100, P.O. Box 20244, 1000 HE Amsterdam, Netherlands.

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SDG 3 Good Health and Well-being

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10.1093/infdis/172.1.97

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title = "The predictive value of t cell function in vitro and pre-AIDS zidovudine use for survival after aids diagnosis in a cohort of homosexual men in Amsterdam",

abstract = "The best independent predictors of survival after AIDS diagnosis were determined in 160 homosexual men from the Amsterdam Cohort Study (1987 CDC case definition). In a Cox model, all pre-AIDS laboratory markers gathered during follow-up in the study did not independently predict survival after AIDS. A second analysis, using data available only at AIDS diagnosis, revealed that T cell reactivity after stimulation with phytohemagglutinin and monoclonal CD3 antibodies and the CD4+ cell count at diagnosis were independent predictors of survival. In an interval-based Cox model, the predictive value of pre-AIDS zidovudine use was determined. One year after AIDS diagnosis, participants with pre-AIDS zidovudine use had a worse survival probability (relative hazard = 3.99). In conclusion, the survival probability of homosexual men with AIDS can be estimated adequately using information obtained at clinical AIDS diagnosis. Analysis revealed the important predictive value of T cell function tests in vitro.",

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note = "Funding Information: Received 1 November 1994; revised 7 March 1995. Grant support: Netherlands Foundation for Preventive Medicine and Advisory Council on Health Research, Program Committee for AIDS Research (28-2370 and 118775). Reprints or correspondence: Dr. Patrick J. E. Bindels, Dept. of Public Health, Nieuwe Achtergracht 100, P.O. Box 20244, 1000 HE Amsterdam, Netherlands.",

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doi = "10.1093/infdis/172.1.97",

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T1 - The predictive value of t cell function in vitro and pre-AIDS zidovudine use for survival after aids diagnosis in a cohort of homosexual men in Amsterdam

AU - Bindels, Patrick J.E.

AU - Krol, Anneke

AU - Roos, Marijke

AU - Veenstra, Jan

AU - Van den Hoek, Johanna A.R.

AU - Miedema, Frank

AU - Coutinho, Roel A.

N1 - Funding Information: Received 1 November 1994; revised 7 March 1995. Grant support: Netherlands Foundation for Preventive Medicine and Advisory Council on Health Research, Program Committee for AIDS Research (28-2370 and 118775). Reprints or correspondence: Dr. Patrick J. E. Bindels, Dept. of Public Health, Nieuwe Achtergracht 100, P.O. Box 20244, 1000 HE Amsterdam, Netherlands.

PY - 1995/7

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N2 - The best independent predictors of survival after AIDS diagnosis were determined in 160 homosexual men from the Amsterdam Cohort Study (1987 CDC case definition). In a Cox model, all pre-AIDS laboratory markers gathered during follow-up in the study did not independently predict survival after AIDS. A second analysis, using data available only at AIDS diagnosis, revealed that T cell reactivity after stimulation with phytohemagglutinin and monoclonal CD3 antibodies and the CD4+ cell count at diagnosis were independent predictors of survival. In an interval-based Cox model, the predictive value of pre-AIDS zidovudine use was determined. One year after AIDS diagnosis, participants with pre-AIDS zidovudine use had a worse survival probability (relative hazard = 3.99). In conclusion, the survival probability of homosexual men with AIDS can be estimated adequately using information obtained at clinical AIDS diagnosis. Analysis revealed the important predictive value of T cell function tests in vitro.

AB - The best independent predictors of survival after AIDS diagnosis were determined in 160 homosexual men from the Amsterdam Cohort Study (1987 CDC case definition). In a Cox model, all pre-AIDS laboratory markers gathered during follow-up in the study did not independently predict survival after AIDS. A second analysis, using data available only at AIDS diagnosis, revealed that T cell reactivity after stimulation with phytohemagglutinin and monoclonal CD3 antibodies and the CD4+ cell count at diagnosis were independent predictors of survival. In an interval-based Cox model, the predictive value of pre-AIDS zidovudine use was determined. One year after AIDS diagnosis, participants with pre-AIDS zidovudine use had a worse survival probability (relative hazard = 3.99). In conclusion, the survival probability of homosexual men with AIDS can be estimated adequately using information obtained at clinical AIDS diagnosis. Analysis revealed the important predictive value of T cell function tests in vitro.

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The predictive value of t cell function in vitro and pre-AIDS zidovudine use for survival after aids diagnosis in a cohort of homosexual men in Amsterdam

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Bibliographical note

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