The prevalence and prognostic value of low muscle mass in cancer patients: A review of the literature

Hánah N. Rier*, Agnes Jager, Stefan Sleijfer, Andrea B. Maier, Mark David Levin

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

113 Citations (Scopus)

Abstract

In several diseases, low muscle mass has been revealed as an unfavorable prognostic factor for out come. Whet her this holds true in patients with solid malignancies as well has increasingly been explored recently. However, this research field is severely hampered by a lack of consensus on how to determine muscle mass in cancer patients and on the definition of low muscle mass. Consequently, the prevalence of low muscle mass varies widely across several studies. Never the less, most studies show that, in patients with solid malignancies, low muscle mass is associated with a poor out come. In the future, more research is needed to get better insight into the best method to determine muscle mass, the exact prognostic value of low muscle mass in diverse tumor types and stages, pathophysiology of low muscle mass in patients with cancer, and ways to intervene and improve muscle mass in patients. This review addresses the current literature on the importance of muscle mass in cancer patients and the methods of muscle measurement.

Original languageEnglish
Pages (from-to)1396-1409
Number of pages14
JournalOncologist
Volume21
Issue number11
DOIs
Publication statusPublished - Nov 2016

Bibliographical note

Publisher Copyright:
© AlphaMed Press 2016.

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