The proactive wet-wrap method with diluted corticosteroids versus emollients in children with atopic dermatitis: A prospective, randomized, double-blind, placebo-controlled trial

Janmohamed, Arnold Oranje, AC Devillers, Dimitris Rizopoulos, MCG Praag, D van Gysel, M Goeteyn, FB Spek

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67 Citations (Scopus)


Background: Wet-wrap treatment (WWT) has been advocated as a relatively effective treatment in children with severe atopic dermatitis (AD). WWT often serves as crisis intervention for AD. Objectives: We sought to evaluate the use of WWT with diluted corticosteroids in comparison with emollient in children with severe AD during 4 weeks in a proactive schedule during which the frequency of corticosteroid applications was tapered. Methods: A randomized, double-blind, placebo-controlled study was performed in children aged 6 months to 10 years with severe AD (objective SCORAD at least 40 +/- 5), comparing WWT with diluted corticosteroids (1: 3 mometasone furoate 0.1% ointment and for the face 1:19 mometasone furoate 0.1% ointment under a mask) with emollient (petrolatum 20% in cetomacrogol cream). The primary outcome was improvement of the objective SCORAD; secondary outcomes included Patient-Oriented Eczema Measure and quality-of-life index. Results: WWT with diluted corticosteroids acted faster and was more efficacious than WWT with emollients. Best results were obtained in age groups 6 to 9 years and 0 to 3 years. The difference in efficacy evaluated by objective SCORAD was significant at all measuring points. This also applied to the quality-of-life index. Limitations: The study group was relatively small. Conclusions: WWT for severe AD is an effective therapy option for at least a period of 4 weeks.
Original languageUndefined/Unknown
Pages (from-to)1076-1082
Number of pages7
JournalJournal of the American Academy of Dermatology
Issue number6
Publication statusPublished - 2014

Research programs

  • EMC NIHES-01-66-01

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