The Prognostic Value of a Validated and Automated Intravascular Ultrasound-Derived Calcium Score

Tara Neleman; Shengnan Liu; Maria N. Tovar Forero; Eline M.J. Hartman; Jurgen M.R. Ligthart; Karen T. Witberg; Paul Cummins; Felix Zijlstra; Nicolas M. Van Mieghem; Eric Boersma; Gijs van Soest; Joost Daemen

doi:10.1007/s12265-021-10103-1

The Prognostic Value of a Validated and Automated Intravascular Ultrasound-Derived Calcium Score

Tara Neleman, Shengnan Liu, Maria N. Tovar Forero, Eline M.J. Hartman, Jurgen M.R. Ligthart, Karen T. Witberg, Paul Cummins, Felix Zijlstra, Nicolas M. Van Mieghem, Eric Boersma, Gijs van Soest, Joost Daemen^*

^*Corresponding author for this work

Cardiology

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Background: Coronary calcification has been linked to cardiovascular events. We developed and validated an algorithm to automatically quantify coronary calcifications on intravascular ultrasound (IVUS). We aimed to assess the prognostic value of an IVUS-calcium score (ICS) on patient-oriented composite endpoint (POCE). Methods: We included patients that underwent coronary angiography plus pre-procedural IVUS imaging. The ICS was calculated per patient. The primary endpoint was a composite of all-cause mortality, stroke, myocardial infarction, and revascularization (POCE). Results: In a cohort of 408 patients, median ICS was 85. Both an ICS ≥ 85 and a 100 unit increase in ICS increased the risk of POCE at 6-year follow-up (adjusted hazard ratio (aHR) 1.51, 95%CI 1.05–2.17, p value = 0.026, and aHR 1.21, 95%CI 1.04–1.41, p value = 0.014, respectively). Conclusions: The ICS, calculated by a validated automated algorithm derived from routine IVUS pullbacks, was strongly associated with the long-term risk of POCE. Graphical abstract: [Figure not available: see fulltext.]

Original language	English
Pages (from-to)	992-1000
Number of pages	9
Journal	Journal of Cardiovascular Translational Research
Volume	14
Issue number	5
Early online date	23 Feb 2021
DOIs	https://doi.org/10.1007/s12265-021-10103-1
Publication status	Published - Oct 2021

Bibliographical note

Funding Information:
Joost Daemen received institutional research support from Astra Zeneca, Abbott Vascular, Boston Scientific, Acist Medical, Medtronic, Pie Medical, ReCor medical, and PulseCath and consultancy and speaker fees from Acist Medical, Boston Scientific, ReCor Medical, Pie Medical, Medtronic, and PulseCath. Nicolas M van Mieghem received research grant support from Edwards, Medtronic, Abbott, Boston Scientific, PulseCath, Acist Medical, and Essential Medical. Tara Neleman received institutional research grant support from Acist Medical.

Funding Information:
This research project was conducted during a research internship as part of the Research Master Clinical Research at the Netherlands Institute for Health Sciences.

Publisher Copyright:
© 2021, The Author(s).

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Neleman, T., Liu, S., Tovar Forero, M. N., Hartman, E. M. J., Ligthart, J. M. R., Witberg, K. T., Cummins, P., Zijlstra, F., Van Mieghem, N. M., Boersma, E., van Soest, G., & Daemen, J. (2021). The Prognostic Value of a Validated and Automated Intravascular Ultrasound-Derived Calcium Score. Journal of Cardiovascular Translational Research, 14(5), 992-1000. https://doi.org/10.1007/s12265-021-10103-1

@article{643c9c9c22ef48368c680e7e0756e5dd,

title = "The Prognostic Value of a Validated and Automated Intravascular Ultrasound-Derived Calcium Score",

abstract = "Background: Coronary calcification has been linked to cardiovascular events. We developed and validated an algorithm to automatically quantify coronary calcifications on intravascular ultrasound (IVUS). We aimed to assess the prognostic value of an IVUS-calcium score (ICS) on patient-oriented composite endpoint (POCE). Methods: We included patients that underwent coronary angiography plus pre-procedural IVUS imaging. The ICS was calculated per patient. The primary endpoint was a composite of all-cause mortality, stroke, myocardial infarction, and revascularization (POCE). Results: In a cohort of 408 patients, median ICS was 85. Both an ICS ≥ 85 and a 100 unit increase in ICS increased the risk of POCE at 6-year follow-up (adjusted hazard ratio (aHR) 1.51, 95%CI 1.05–2.17, p value = 0.026, and aHR 1.21, 95%CI 1.04–1.41, p value = 0.014, respectively). Conclusions: The ICS, calculated by a validated automated algorithm derived from routine IVUS pullbacks, was strongly associated with the long-term risk of POCE. Graphical abstract: [Figure not available: see fulltext.]",

author = "Tara Neleman and Shengnan Liu and {Tovar Forero}, {Maria N.} and Hartman, {Eline M.J.} and Ligthart, {Jurgen M.R.} and Witberg, {Karen T.} and Paul Cummins and Felix Zijlstra and {Van Mieghem}, {Nicolas M.} and Eric Boersma and {van Soest}, Gijs and Joost Daemen",

note = "Funding Information: Joost Daemen received institutional research support from Astra Zeneca, Abbott Vascular, Boston Scientific, Acist Medical, Medtronic, Pie Medical, ReCor medical, and PulseCath and consultancy and speaker fees from Acist Medical, Boston Scientific, ReCor Medical, Pie Medical, Medtronic, and PulseCath. Nicolas M van Mieghem received research grant support from Edwards, Medtronic, Abbott, Boston Scientific, PulseCath, Acist Medical, and Essential Medical. Tara Neleman received institutional research grant support from Acist Medical. Funding Information: This research project was conducted during a research internship as part of the Research Master Clinical Research at the Netherlands Institute for Health Sciences. Publisher Copyright: {\textcopyright} 2021, The Author(s).",

year = "2021",

month = oct,

doi = "10.1007/s12265-021-10103-1",

language = "English",

volume = "14",

pages = "992--1000",

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Neleman, T , Liu, S, Tovar Forero, MN, Hartman, EMJ, Ligthart, JMR , Witberg, KT , Cummins, P , Zijlstra, F , Van Mieghem, NM , Boersma, E , van Soest, G & Daemen, J 2021, 'The Prognostic Value of a Validated and Automated Intravascular Ultrasound-Derived Calcium Score', Journal of Cardiovascular Translational Research, vol. 14, no. 5, pp. 992-1000. https://doi.org/10.1007/s12265-021-10103-1

TY - JOUR

T1 - The Prognostic Value of a Validated and Automated Intravascular Ultrasound-Derived Calcium Score

AU - Neleman, Tara

AU - Liu, Shengnan

AU - Tovar Forero, Maria N.

AU - Hartman, Eline M.J.

AU - Ligthart, Jurgen M.R.

AU - Witberg, Karen T.

AU - Cummins, Paul

AU - Zijlstra, Felix

AU - Van Mieghem, Nicolas M.

AU - Boersma, Eric

AU - van Soest, Gijs

AU - Daemen, Joost

N1 - Funding Information: Joost Daemen received institutional research support from Astra Zeneca, Abbott Vascular, Boston Scientific, Acist Medical, Medtronic, Pie Medical, ReCor medical, and PulseCath and consultancy and speaker fees from Acist Medical, Boston Scientific, ReCor Medical, Pie Medical, Medtronic, and PulseCath. Nicolas M van Mieghem received research grant support from Edwards, Medtronic, Abbott, Boston Scientific, PulseCath, Acist Medical, and Essential Medical. Tara Neleman received institutional research grant support from Acist Medical. Funding Information: This research project was conducted during a research internship as part of the Research Master Clinical Research at the Netherlands Institute for Health Sciences. Publisher Copyright: © 2021, The Author(s).

PY - 2021/10

Y1 - 2021/10

N2 - Background: Coronary calcification has been linked to cardiovascular events. We developed and validated an algorithm to automatically quantify coronary calcifications on intravascular ultrasound (IVUS). We aimed to assess the prognostic value of an IVUS-calcium score (ICS) on patient-oriented composite endpoint (POCE). Methods: We included patients that underwent coronary angiography plus pre-procedural IVUS imaging. The ICS was calculated per patient. The primary endpoint was a composite of all-cause mortality, stroke, myocardial infarction, and revascularization (POCE). Results: In a cohort of 408 patients, median ICS was 85. Both an ICS ≥ 85 and a 100 unit increase in ICS increased the risk of POCE at 6-year follow-up (adjusted hazard ratio (aHR) 1.51, 95%CI 1.05–2.17, p value = 0.026, and aHR 1.21, 95%CI 1.04–1.41, p value = 0.014, respectively). Conclusions: The ICS, calculated by a validated automated algorithm derived from routine IVUS pullbacks, was strongly associated with the long-term risk of POCE. Graphical abstract: [Figure not available: see fulltext.]

AB - Background: Coronary calcification has been linked to cardiovascular events. We developed and validated an algorithm to automatically quantify coronary calcifications on intravascular ultrasound (IVUS). We aimed to assess the prognostic value of an IVUS-calcium score (ICS) on patient-oriented composite endpoint (POCE). Methods: We included patients that underwent coronary angiography plus pre-procedural IVUS imaging. The ICS was calculated per patient. The primary endpoint was a composite of all-cause mortality, stroke, myocardial infarction, and revascularization (POCE). Results: In a cohort of 408 patients, median ICS was 85. Both an ICS ≥ 85 and a 100 unit increase in ICS increased the risk of POCE at 6-year follow-up (adjusted hazard ratio (aHR) 1.51, 95%CI 1.05–2.17, p value = 0.026, and aHR 1.21, 95%CI 1.04–1.41, p value = 0.014, respectively). Conclusions: The ICS, calculated by a validated automated algorithm derived from routine IVUS pullbacks, was strongly associated with the long-term risk of POCE. Graphical abstract: [Figure not available: see fulltext.]

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U2 - 10.1007/s12265-021-10103-1

DO - 10.1007/s12265-021-10103-1

M3 - Article

C2 - 33624259

AN - SCOPUS:85101422189

SN - 1937-5387

VL - 14

SP - 992

EP - 1000

JO - Journal of Cardiovascular Translational Research

JF - Journal of Cardiovascular Translational Research

IS - 5

ER -

The Prognostic Value of a Validated and Automated Intravascular Ultrasound-Derived Calcium Score

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