The Prognostic Value of Eight Immunohistochemical Markers Expressed in the Tumor Microenvironment and on Hodgkin Reed-Sternberg Cells in Pediatric Patients With Classical Hodgkin Lymphoma

Eline A.M. Zijtregtop; Ilse Tromp; Rana Dandis; Christian M. Zwaan; King H. Lam; Friederike A.G. Meyer-Wentrup; Auke Beishuizen

doi:10.3389/pore.2022.1610482

The Prognostic Value of Eight Immunohistochemical Markers Expressed in the Tumor Microenvironment and on Hodgkin Reed-Sternberg Cells in Pediatric Patients With Classical Hodgkin Lymphoma

Eline A.M. Zijtregtop
, Ilse Tromp
, Rana Dandis
, Christian M. Zwaan
, King H. Lam
, Friederike A.G. Meyer-Wentrup
, Auke Beishuizen^*

^*Corresponding author for this work

Princess Máxima Center for Pediatric Oncology

Research output: Contribution to journal › Article › Academic › peer-review

4 Citations (Scopus)

42 Downloads (Pure)

Abstract

Immunohistochemical markers are associated with treatment outcome in adults with classical Hodgkin Lymphoma (cHL). Studies in children are scarce and inconsistent. We investigated in 67 children with cHL, whether the expression of CD15, CD30, PAX5, PD-1, PD-L1, CD68, CD163 and TARC at diagnosis is associated with disease free survival (DFS) and with interim remission status. Low CD15 and low TARC expression were associated with relapsed disease. Low expression of PD-L1 was associated with complete remission at interim PET-scan. Our data suggest a difference between pediatric and adult cHL. This underlines the importance of future research into specific prognostic factors in pediatric cHL, indispensable for improvement of treatment in this population.

Original language	English
Article number	1610482
Journal	Pathology and Oncology Research
Volume	28
DOIs	https://doi.org/10.3389/pore.2022.1610482
Publication status	Published - 11 Aug 2022

Bibliographical note

Funding Information:
This work was financially supported by the Ferenc Foundation and the Erasmus MC Foundation, enabled by a legacy of the family Etienne-van Dijk. We would like to thank them both. The funding source had no involvement on the study design, data collection, data analysis, interpretation of data, writing the report or the decision to submit the paper for publication.

Publisher Copyright:
Copyright © 2022 Zijtregtop, Tromp, Dandis, Zwaan, Lam, Meyer-Wentrup and Beishuizen.

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SDG 3 Good Health and Well-being

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The Prognostic Value of Eight Immunohistochemical Markers Expressed in the Tumor Microenvironment and on Hodgkin Reed-Sternberg Cells in Pediatric Patients With Classical Hodgkin LymphomaFinal published version, 1.56 MBLicence: CC BY

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Zijtregtop, E. A. M., Tromp, I., Dandis, R., Zwaan, C. M., Lam, K. H., Meyer-Wentrup, F. A. G., & Beishuizen, A. (2022). The Prognostic Value of Eight Immunohistochemical Markers Expressed in the Tumor Microenvironment and on Hodgkin Reed-Sternberg Cells in Pediatric Patients With Classical Hodgkin Lymphoma. Pathology and Oncology Research, 28, Article 1610482. https://doi.org/10.3389/pore.2022.1610482

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title = "The Prognostic Value of Eight Immunohistochemical Markers Expressed in the Tumor Microenvironment and on Hodgkin Reed-Sternberg Cells in Pediatric Patients With Classical Hodgkin Lymphoma",

abstract = "Immunohistochemical markers are associated with treatment outcome in adults with classical Hodgkin Lymphoma (cHL). Studies in children are scarce and inconsistent. We investigated in 67 children with cHL, whether the expression of CD15, CD30, PAX5, PD-1, PD-L1, CD68, CD163 and TARC at diagnosis is associated with disease free survival (DFS) and with interim remission status. Low CD15 and low TARC expression were associated with relapsed disease. Low expression of PD-L1 was associated with complete remission at interim PET-scan. Our data suggest a difference between pediatric and adult cHL. This underlines the importance of future research into specific prognostic factors in pediatric cHL, indispensable for improvement of treatment in this population.",

author = "Zijtregtop, \{Eline A.M.\} and Ilse Tromp and Rana Dandis and Zwaan, \{Christian M.\} and Lam, \{King H.\} and Meyer-Wentrup, \{Friederike A.G.\} and Auke Beishuizen",

note = "Funding Information: This work was financially supported by the Ferenc Foundation and the Erasmus MC Foundation, enabled by a legacy of the family Etienne-van Dijk. We would like to thank them both. The funding source had no involvement on the study design, data collection, data analysis, interpretation of data, writing the report or the decision to submit the paper for publication. Publisher Copyright: Copyright {\textcopyright} 2022 Zijtregtop, Tromp, Dandis, Zwaan, Lam, Meyer-Wentrup and Beishuizen.",

year = "2022",

month = aug,

day = "11",

doi = "10.3389/pore.2022.1610482",

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Zijtregtop, EAM, Tromp, I, Dandis, R, Zwaan, CM , Lam, KH, Meyer-Wentrup, FAG & Beishuizen, A 2022, 'The Prognostic Value of Eight Immunohistochemical Markers Expressed in the Tumor Microenvironment and on Hodgkin Reed-Sternberg Cells in Pediatric Patients With Classical Hodgkin Lymphoma', Pathology and Oncology Research, vol. 28, 1610482. https://doi.org/10.3389/pore.2022.1610482

The Prognostic Value of Eight Immunohistochemical Markers Expressed in the Tumor Microenvironment and on Hodgkin Reed-Sternberg Cells in Pediatric Patients With Classical Hodgkin Lymphoma. / Zijtregtop, Eline A.M.; Tromp, Ilse; Dandis, Rana et al.
In: Pathology and Oncology Research, Vol. 28, 1610482, 11.08.2022.

Research output: Contribution to journal › Article › Academic › peer-review

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T1 - The Prognostic Value of Eight Immunohistochemical Markers Expressed in the Tumor Microenvironment and on Hodgkin Reed-Sternberg Cells in Pediatric Patients With Classical Hodgkin Lymphoma

AU - Zijtregtop, Eline A.M.

AU - Tromp, Ilse

AU - Dandis, Rana

AU - Zwaan, Christian M.

AU - Lam, King H.

AU - Meyer-Wentrup, Friederike A.G.

AU - Beishuizen, Auke

N1 - Funding Information: This work was financially supported by the Ferenc Foundation and the Erasmus MC Foundation, enabled by a legacy of the family Etienne-van Dijk. We would like to thank them both. The funding source had no involvement on the study design, data collection, data analysis, interpretation of data, writing the report or the decision to submit the paper for publication. Publisher Copyright: Copyright © 2022 Zijtregtop, Tromp, Dandis, Zwaan, Lam, Meyer-Wentrup and Beishuizen.

PY - 2022/8/11

Y1 - 2022/8/11

N2 - Immunohistochemical markers are associated with treatment outcome in adults with classical Hodgkin Lymphoma (cHL). Studies in children are scarce and inconsistent. We investigated in 67 children with cHL, whether the expression of CD15, CD30, PAX5, PD-1, PD-L1, CD68, CD163 and TARC at diagnosis is associated with disease free survival (DFS) and with interim remission status. Low CD15 and low TARC expression were associated with relapsed disease. Low expression of PD-L1 was associated with complete remission at interim PET-scan. Our data suggest a difference between pediatric and adult cHL. This underlines the importance of future research into specific prognostic factors in pediatric cHL, indispensable for improvement of treatment in this population.

AB - Immunohistochemical markers are associated with treatment outcome in adults with classical Hodgkin Lymphoma (cHL). Studies in children are scarce and inconsistent. We investigated in 67 children with cHL, whether the expression of CD15, CD30, PAX5, PD-1, PD-L1, CD68, CD163 and TARC at diagnosis is associated with disease free survival (DFS) and with interim remission status. Low CD15 and low TARC expression were associated with relapsed disease. Low expression of PD-L1 was associated with complete remission at interim PET-scan. Our data suggest a difference between pediatric and adult cHL. This underlines the importance of future research into specific prognostic factors in pediatric cHL, indispensable for improvement of treatment in this population.

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JO - Pathology and Oncology Research

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M1 - 1610482

ER -

The Prognostic Value of Eight Immunohistochemical Markers Expressed in the Tumor Microenvironment and on Hodgkin Reed-Sternberg Cells in Pediatric Patients With Classical Hodgkin Lymphoma

Abstract

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