The prostate-specific antigen gene and the human glandular kallikrein-1 gene are tandemly located on chromosome 19

P. H.J. Riegman; R. J. Vlietstra; P. Klaassen; J. A.G.M. van der Korput; A. Geurts van Kessel; J. C. Romijn; J. Trapman

doi:10.1016/0014-5793(89)81253-0

The prostate-specific antigen gene and the human glandular kallikrein-1 gene are tandemly located on chromosome 19

P. H.J. Riegman^*, R. J. Vlietstra, P. Klaassen, J. A.G.M. van der Korput, A. Geurts van Kessel, J. C. Romijn, J. Trapman

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Using a prostate-specific antigen cDNA as a hybridization probe, clones containing the kallikrein genes encoding prostate-specific antigen, human glandular kallikrein-1 and pancreas/kidney kallikrein were isolated from a human genomic library. Clones containing the prostate-specific antigen gene and the human glandular kallikrein-1 gene overlap and span a region of about 36 kb. The two genes are aligned in a head to tail orientation at a mutual distance of 12 kb. Southern blot analysis of DNA from a panel of human-hamster hybrid cells with specific probes revealed the genes to be situated on chromosome 19. Assuming that the pancreas/kidney kallikrein gene is located in the same cluster, the distance to the prostate-specific antigen gene and the human glandular kallikrein gene must be at least 15 kb.

Original language	English
Pages (from-to)	123-126
Number of pages	4
Journal	FEBS Letters
Volume	247
Issue number	1
DOIs	https://doi.org/10.1016/0014-5793(89)81253-0
Publication status	Published - 10 Apr 1989

Bibliographical note

Funding Information:
AcknowledgementWs:e are indebtedt o Mrs Paula Delfos for photography.T his work has been supportedb y a grant from the NetherlandsC ancerF oundation( KWF).

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title = "The prostate-specific antigen gene and the human glandular kallikrein-1 gene are tandemly located on chromosome 19",

abstract = "Using a prostate-specific antigen cDNA as a hybridization probe, clones containing the kallikrein genes encoding prostate-specific antigen, human glandular kallikrein-1 and pancreas/kidney kallikrein were isolated from a human genomic library. Clones containing the prostate-specific antigen gene and the human glandular kallikrein-1 gene overlap and span a region of about 36 kb. The two genes are aligned in a head to tail orientation at a mutual distance of 12 kb. Southern blot analysis of DNA from a panel of human-hamster hybrid cells with specific probes revealed the genes to be situated on chromosome 19. Assuming that the pancreas/kidney kallikrein gene is located in the same cluster, the distance to the prostate-specific antigen gene and the human glandular kallikrein gene must be at least 15 kb.",

author = "Riegman, {P. H.J.} and Vlietstra, {R. J.} and P. Klaassen and {van der Korput}, {J. A.G.M.} and {van Kessel}, {A. Geurts} and Romijn, {J. C.} and J. Trapman",

note = "Funding Information: AcknowledgementWs:e are indebtedt o Mrs Paula Delfos for photography.T his work has been supportedb y a grant from the NetherlandsC ancerF oundation( KWF).",

year = "1989",

month = apr,

day = "10",

doi = "10.1016/0014-5793(89)81253-0",

language = "English",

volume = "247",

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journal = "FEBS Letters",

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AU - Riegman, P. H.J.

AU - Vlietstra, R. J.

AU - Klaassen, P.

AU - van der Korput, J. A.G.M.

AU - van Kessel, A. Geurts

AU - Romijn, J. C.

AU - Trapman, J.

N1 - Funding Information: AcknowledgementWs:e are indebtedt o Mrs Paula Delfos for photography.T his work has been supportedb y a grant from the NetherlandsC ancerF oundation( KWF).

PY - 1989/4/10

Y1 - 1989/4/10

N2 - Using a prostate-specific antigen cDNA as a hybridization probe, clones containing the kallikrein genes encoding prostate-specific antigen, human glandular kallikrein-1 and pancreas/kidney kallikrein were isolated from a human genomic library. Clones containing the prostate-specific antigen gene and the human glandular kallikrein-1 gene overlap and span a region of about 36 kb. The two genes are aligned in a head to tail orientation at a mutual distance of 12 kb. Southern blot analysis of DNA from a panel of human-hamster hybrid cells with specific probes revealed the genes to be situated on chromosome 19. Assuming that the pancreas/kidney kallikrein gene is located in the same cluster, the distance to the prostate-specific antigen gene and the human glandular kallikrein gene must be at least 15 kb.

AB - Using a prostate-specific antigen cDNA as a hybridization probe, clones containing the kallikrein genes encoding prostate-specific antigen, human glandular kallikrein-1 and pancreas/kidney kallikrein were isolated from a human genomic library. Clones containing the prostate-specific antigen gene and the human glandular kallikrein-1 gene overlap and span a region of about 36 kb. The two genes are aligned in a head to tail orientation at a mutual distance of 12 kb. Southern blot analysis of DNA from a panel of human-hamster hybrid cells with specific probes revealed the genes to be situated on chromosome 19. Assuming that the pancreas/kidney kallikrein gene is located in the same cluster, the distance to the prostate-specific antigen gene and the human glandular kallikrein gene must be at least 15 kb.

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JO - FEBS Letters

JF - FEBS Letters

IS - 1

ER -

The prostate-specific antigen gene and the human glandular kallikrein-1 gene are tandemly located on chromosome 19

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