The prostate-specific antigen gene and the human glandular kallikrein-1 gene are tandemly located on chromosome 19

P. H.J. Riegman; R. J. Vlietstra; P. Klaassen; J. A.G.M. van der Korput; A. Geurts van Kessel; J. C. Romijn; J. Trapman

doi:10.1016/0014-5793(89)81253-0

The prostate-specific antigen gene and the human glandular kallikrein-1 gene are tandemly located on chromosome 19

P. H.J. Riegman^*
, R. J. Vlietstra
, P. Klaassen
, J. A.G.M. van der Korput
, A. Geurts van Kessel
, J. C. Romijn
, J. Trapman

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

86 Citations (Scopus)

Abstract

Using a prostate-specific antigen cDNA as a hybridization probe, clones containing the kallikrein genes encoding prostate-specific antigen, human glandular kallikrein-1 and pancreas/kidney kallikrein were isolated from a human genomic library. Clones containing the prostate-specific antigen gene and the human glandular kallikrein-1 gene overlap and span a region of about 36 kb. The two genes are aligned in a head to tail orientation at a mutual distance of 12 kb. Southern blot analysis of DNA from a panel of human-hamster hybrid cells with specific probes revealed the genes to be situated on chromosome 19. Assuming that the pancreas/kidney kallikrein gene is located in the same cluster, the distance to the prostate-specific antigen gene and the human glandular kallikrein gene must be at least 15 kb.

Original language	English
Pages (from-to)	123-126
Number of pages	4
Journal	FEBS Letters
Volume	247
Issue number	1
DOIs	https://doi.org/10.1016/0014-5793(89)81253-0
Publication status	Published - 10 Apr 1989

Bibliographical note

Funding Information:
AcknowledgementWs:e are indebtedt o Mrs Paula Delfos for photography.T his work has been supportedb y a grant from the NetherlandsC ancerF oundation( KWF).

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10.1016/0014-5793(89)81253-0

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@article{9f302ac0dbe644d39c14e3d66a6a7537,

title = "The prostate-specific antigen gene and the human glandular kallikrein-1 gene are tandemly located on chromosome 19",

abstract = "Using a prostate-specific antigen cDNA as a hybridization probe, clones containing the kallikrein genes encoding prostate-specific antigen, human glandular kallikrein-1 and pancreas/kidney kallikrein were isolated from a human genomic library. Clones containing the prostate-specific antigen gene and the human glandular kallikrein-1 gene overlap and span a region of about 36 kb. The two genes are aligned in a head to tail orientation at a mutual distance of 12 kb. Southern blot analysis of DNA from a panel of human-hamster hybrid cells with specific probes revealed the genes to be situated on chromosome 19. Assuming that the pancreas/kidney kallikrein gene is located in the same cluster, the distance to the prostate-specific antigen gene and the human glandular kallikrein gene must be at least 15 kb.",

author = "Riegman, \{P. H.J.\} and Vlietstra, \{R. J.\} and P. Klaassen and \{van der Korput\}, \{J. A.G.M.\} and \{van Kessel\}, \{A. Geurts\} and Romijn, \{J. C.\} and J. Trapman",

note = "Funding Information: AcknowledgementWs:e are indebtedt o Mrs Paula Delfos for photography.T his work has been supportedb y a grant from the NetherlandsC ancerF oundation( KWF).",

year = "1989",

month = apr,

day = "10",

doi = "10.1016/0014-5793(89)81253-0",

language = "English",

volume = "247",

pages = "123--126",

journal = "FEBS Letters",

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T1 - The prostate-specific antigen gene and the human glandular kallikrein-1 gene are tandemly located on chromosome 19

AU - Riegman, P. H.J.

AU - Vlietstra, R. J.

AU - Klaassen, P.

AU - van der Korput, J. A.G.M.

AU - van Kessel, A. Geurts

AU - Romijn, J. C.

AU - Trapman, J.

N1 - Funding Information: AcknowledgementWs:e are indebtedt o Mrs Paula Delfos for photography.T his work has been supportedb y a grant from the NetherlandsC ancerF oundation( KWF).

PY - 1989/4/10

Y1 - 1989/4/10

N2 - Using a prostate-specific antigen cDNA as a hybridization probe, clones containing the kallikrein genes encoding prostate-specific antigen, human glandular kallikrein-1 and pancreas/kidney kallikrein were isolated from a human genomic library. Clones containing the prostate-specific antigen gene and the human glandular kallikrein-1 gene overlap and span a region of about 36 kb. The two genes are aligned in a head to tail orientation at a mutual distance of 12 kb. Southern blot analysis of DNA from a panel of human-hamster hybrid cells with specific probes revealed the genes to be situated on chromosome 19. Assuming that the pancreas/kidney kallikrein gene is located in the same cluster, the distance to the prostate-specific antigen gene and the human glandular kallikrein gene must be at least 15 kb.

AB - Using a prostate-specific antigen cDNA as a hybridization probe, clones containing the kallikrein genes encoding prostate-specific antigen, human glandular kallikrein-1 and pancreas/kidney kallikrein were isolated from a human genomic library. Clones containing the prostate-specific antigen gene and the human glandular kallikrein-1 gene overlap and span a region of about 36 kb. The two genes are aligned in a head to tail orientation at a mutual distance of 12 kb. Southern blot analysis of DNA from a panel of human-hamster hybrid cells with specific probes revealed the genes to be situated on chromosome 19. Assuming that the pancreas/kidney kallikrein gene is located in the same cluster, the distance to the prostate-specific antigen gene and the human glandular kallikrein gene must be at least 15 kb.

UR - https://www.scopus.com/pages/publications/0024517463

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DO - 10.1016/0014-5793(89)81253-0

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C2 - 2468530

AN - SCOPUS:0024517463

SN - 0014-5793

VL - 247

SP - 123

EP - 126

JO - FEBS Letters

JF - FEBS Letters

IS - 1

ER -

The prostate-specific antigen gene and the human glandular kallikrein-1 gene are tandemly located on chromosome 19

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