TY - JOUR
T1 - The relationship between brain structure volumes, depressive symptoms and body composition in obese/overweight and normal-/underweight women
AU - Łapińska, Lidia
AU - Szum-Jakubowska, Aleksandra
AU - Krentowska, Anna
AU - Pawlak, Mikołaj
AU - Hładuński, Marcin
AU - Waszkiewicz, Napoleon
AU - Karczewska-Kupczewska, Monika
AU - Kamiński, Karol
AU - Kowalska, Irina
N1 - Publisher Copyright:
© The Author(s) 2024.
PY - 2024/9/9
Y1 - 2024/9/9
N2 - Depressive symptoms are highly prevalent and heterogeneous in women. Different brain structures might be associated with depressive symptoms and body composition in women with obesity/overweight and normal-/underweight, although the data is limited. The analysis included 265 women from Bialystok PLUS population study, untreated with antidepressive or antipsychotic medications. The subjects underwent brain magnetic resonance imaging and body composition analysis. Beck Depression Inventory (BDI) score was inversely associated with nucleus accumbens volume (β = −0.217, p = 0.008) in women with BMI ≥ 25 kg/m2, but with insula volume (β = −0.147, p = 0.027) in women with BMI < 25 kg/m2 after adjustment for age and estimated intracranial volume (eTIV). In women with BMI ≥ 25 kg/m2, nucleus accumbens volume was inversely associated with the percentage of visceral fat and BDI score (β = −0.236, p = 0.012, β = −0.192, p = 0.017) after adjustment for age and eTIV. In women with BMI < 25 kg/m2, insula volume was positively associated with total fat-free mass and negatively with the BDI score (β = 0.142, p = 0.030, β = −0.137, p = 0.037) after adjustment for age and eTIV. Depressive symptoms might be associated with nucleus accumbens volume in overweight/obese women, while in normal-/ underweight women—with alterations in insula volume.
AB - Depressive symptoms are highly prevalent and heterogeneous in women. Different brain structures might be associated with depressive symptoms and body composition in women with obesity/overweight and normal-/underweight, although the data is limited. The analysis included 265 women from Bialystok PLUS population study, untreated with antidepressive or antipsychotic medications. The subjects underwent brain magnetic resonance imaging and body composition analysis. Beck Depression Inventory (BDI) score was inversely associated with nucleus accumbens volume (β = −0.217, p = 0.008) in women with BMI ≥ 25 kg/m2, but with insula volume (β = −0.147, p = 0.027) in women with BMI < 25 kg/m2 after adjustment for age and estimated intracranial volume (eTIV). In women with BMI ≥ 25 kg/m2, nucleus accumbens volume was inversely associated with the percentage of visceral fat and BDI score (β = −0.236, p = 0.012, β = −0.192, p = 0.017) after adjustment for age and eTIV. In women with BMI < 25 kg/m2, insula volume was positively associated with total fat-free mass and negatively with the BDI score (β = 0.142, p = 0.030, β = −0.137, p = 0.037) after adjustment for age and eTIV. Depressive symptoms might be associated with nucleus accumbens volume in overweight/obese women, while in normal-/ underweight women—with alterations in insula volume.
UR - http://www.scopus.com/inward/record.url?scp=85203371474&partnerID=8YFLogxK
U2 - 10.1038/s41598-024-71924-z
DO - 10.1038/s41598-024-71924-z
M3 - Article
C2 - 39251805
AN - SCOPUS:85203371474
SN - 2045-2322
VL - 14
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 21021
ER -
