TY - JOUR
T1 - The relationship between primary colorectal cancer histology and the histopathological growth patterns of corresponding liver metastases
AU - Höppener, Diederik J
AU - Stook, Jean-Luc P L
AU - PALGA-group
AU - Galjart, Boris
AU - Nierop, Pieter M H
AU - Nagtegaal, Iris D
AU - Vermeulen, Peter B
AU - Grünhagen, Dirk J
AU - Verhoef, Cornelis
AU - Doukas, Michail
N1 - Funding Information:
This study was partly funded by a grant from Stichting Coolsingel, Rotterdam, the Netherlands.
Publisher Copyright:
© 2022, The Author(s).
PY - 2022/8/22
Y1 - 2022/8/22
N2 - BACKGROUND: The histopathological growth patterns (HGPs) are a prognostic and predictive biomarker in colorectal cancer liver metastasis (CRLM). This study evaluates the relationship between the HGP and primary colorectal cancer (CRC) histopathology.METHODS: A total of 183 treatment-naive patients with resected CRC and CRLM were included. Thirteen CRC histopathology markers were determined and compared between the desmoplastic and non-desmoplastic HGP; tumour sidedness, pT&pN stage, tumour grade, tumour deposits, perineural- (lympho-)vascular- and extramural venous invasion, peritumoural budding, stroma type, CRC growth pattern, Crohn's-like lymphoid reaction, and tumour-infiltrating lymphocyte (TIL) density. Logistic regression analysis was performed using both CRC and CRLM characteristics.RESULTS: Unfavourable CRC histopathology was more frequent in non-desmoplastic CRLM for all markers evaluated, and significantly so for a lower TIL density, absent Crohn's-like lymphoid reaction, and a "non-mature" stroma (all p < 0.03). The cumulative prevalence of unfavourable CRC histopathology was significantly higher in patients with non-desmoplastic compared to desmoplastic CRLM, with a median (IQR) of 4 (3-6) vs 2 (1-3.5) unfavourable characteristics observed, respectively (p < 0.001). Multivariable regression with 9 CRC histopathology markers and 2 CRLM characteristics achieved good discriminatory performance (AUC = 0.83).CONCLUSIONS: The results of this study associates primary CRC histopathology with the HGP of corresponding liver metastases.
AB - BACKGROUND: The histopathological growth patterns (HGPs) are a prognostic and predictive biomarker in colorectal cancer liver metastasis (CRLM). This study evaluates the relationship between the HGP and primary colorectal cancer (CRC) histopathology.METHODS: A total of 183 treatment-naive patients with resected CRC and CRLM were included. Thirteen CRC histopathology markers were determined and compared between the desmoplastic and non-desmoplastic HGP; tumour sidedness, pT&pN stage, tumour grade, tumour deposits, perineural- (lympho-)vascular- and extramural venous invasion, peritumoural budding, stroma type, CRC growth pattern, Crohn's-like lymphoid reaction, and tumour-infiltrating lymphocyte (TIL) density. Logistic regression analysis was performed using both CRC and CRLM characteristics.RESULTS: Unfavourable CRC histopathology was more frequent in non-desmoplastic CRLM for all markers evaluated, and significantly so for a lower TIL density, absent Crohn's-like lymphoid reaction, and a "non-mature" stroma (all p < 0.03). The cumulative prevalence of unfavourable CRC histopathology was significantly higher in patients with non-desmoplastic compared to desmoplastic CRLM, with a median (IQR) of 4 (3-6) vs 2 (1-3.5) unfavourable characteristics observed, respectively (p < 0.001). Multivariable regression with 9 CRC histopathology markers and 2 CRLM characteristics achieved good discriminatory performance (AUC = 0.83).CONCLUSIONS: The results of this study associates primary CRC histopathology with the HGP of corresponding liver metastases.
UR - http://www.scopus.com/inward/record.url?scp=85136182230&partnerID=8YFLogxK
U2 - 10.1186/s12885-022-09994-3
DO - 10.1186/s12885-022-09994-3
M3 - Article
C2 - 35996090
AN - SCOPUS:85136182230
SN - 1471-2407
VL - 22
SP - 911
JO - BMC Cancer
JF - BMC Cancer
IS - 1
M1 - 911
ER -
