The relationship between primary colorectal cancer histology and the histopathological growth patterns of corresponding liver metastases

Diederik J. Höppener, Jean Luc P.L. Stook, PALGA-group, Boris Galjart, Pieter M.H. Nierop, Iris D. Nagtegaal, Peter B. Vermeulen, Dirk J. Grünhagen, Cornelis Verhoef*, Michail Doukas

*Corresponding author for this work

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Abstract

Background: The histopathological growth patterns (HGPs) are a prognostic and predictive biomarker in colorectal cancer liver metastasis (CRLM). This study evaluates the relationship between the HGP and primary colorectal cancer (CRC) histopathology. Methods: A total of 183 treatment-naive patients with resected CRC and CRLM were included. Thirteen CRC histopathology markers were determined and compared between the desmoplastic and non-desmoplastic HGP; tumour sidedness, pT&pN stage, tumour grade, tumour deposits, perineural- (lympho-)vascular- and extramural venous invasion, peritumoural budding, stroma type, CRC growth pattern, Crohn’s-like lymphoid reaction, and tumour-infiltrating lymphocyte (TIL) density. Logistic regression analysis was performed using both CRC and CRLM characteristics. Results: Unfavourable CRC histopathology was more frequent in non-desmoplastic CRLM for all markers evaluated, and significantly so for a lower TIL density, absent Crohn’s-like lymphoid reaction, and a “non-mature” stroma (all p < 0.03). The cumulative prevalence of unfavourable CRC histopathology was significantly higher in patients with non-desmoplastic compared to desmoplastic CRLM, with a median (IQR) of 4 (3–6) vs 2 (1–3.5) unfavourable characteristics observed, respectively (p < 0.001). Multivariable regression with 9 CRC histopathology markers and 2 CRLM characteristics achieved good discriminatory performance (AUC = 0.83). Conclusions: The results of this study associates primary CRC histopathology with the HGP of corresponding liver metastases.

Original languageEnglish
Article number911
JournalBMC Cancer
Volume22
Issue number1
DOIs
Publication statusPublished - 22 Aug 2022

Bibliographical note

Funding Information:
This study was partly funded by a grant from Stichting Coolsingel, Rotterdam, the Netherlands.

Funding Information:
The authors would like to express their gratitude to Stichting Coolsingel (Rotterdam, the Netherlands) for providing part of the funding of this study. PALGA Group: The following departments contributed to the sample collection of this study: -Department of Pathology, Erasmus MC, Rotterdam, the Netherlands -Pathan BV, Rotterdam, the Netherlands -Department of Pathology, Maasstad Hospital, Rotterdam, the Netherlands -Department of Pathology, Bravis Hospital, Bergen op Zoom, the Netherlands

Publisher Copyright:
© 2022, The Author(s).

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