The Role of Adiposity in Cardiometabolic Traits: A Mendelian Randomization Analysis

T Fall; S Hagg; R Magi; A Ploner; K (Kirsten) Fischer; M Horikoshi; AP Sarin; G Thorleifsson; C Ladenvall; M Kals; Maris Kuningas; HHM Draisma; JS Ried; NR van Zuydam; V Huikari; M Mangino; E Sonestedt; B Benyamin; CP Nelson; NV Rivera; K Kristiansson; HY Shen; AS Havulinna; Abbas Dehghan; LA Donnelly; M Kaakinen; ML Nuotio; N Robertson; Renee Bruijn; Arfan Ikram; Najaf Amin; AJ Balmforth; PS Braund; ASF Doney; A Doring; P Elliott; T Esko; OH Franco Duran; S Gretarsdottir; AL Hartikainen; K Heikkila; KH Herzig; H Holm; JJ (Jouke Jan) Hottenga; E Hypponen; T Illig; Aaron Isaacs; B Isomaa; Lennart Karssen; J Kettunen; W Koenig; K Kuulasmaa; T Laatikainen; J Laitinen; C Lindgren; V Lyssenko; E Laara; NW Rayner; S Mannisto; A Pouta; W Rathmann; Fernando Rivadeneira; A Ruokonen; MJ Savolainen; E.J.G. Sijbrands; KS Small; JH Smit; V Steinthorsdottir; AC Syvanen; A Taanila; MD Tobin; André Uitterlinden; SM Willems; G Willemsen; JCM Witteman; M Perola; A Evans; J Ferrieres; J Virtamo; F Kee; DA Tregouet; D Arveiler; P Amouyel; MM Ferrario; P Brambilla; AS Hall; A Heath; PAF Madden; NG Martin; GW Montgomery; JB Whitfield; A Jula; P Knekt; Ben Oostra; Cornelia Duijn; BWJH Penninx; GD Smith; J Kaprio; NJ Samani; C Gieger; A Peters; HE Wichmann; DI Boomsma; EJC de Geus; T Tuomi; C Power; CJ Hammond; TD Spector; L Lind; M Orho-Melander; CNA Palmer; AD Morris; L Groop; MR Jarvelin; V Salomaa; E Vartiainen; Bert Hofman; S Ripatti; A Metspalu; U Thorsteinsdottir; K Stefansson; NL Pedersen; MI McCarthy; E Ingelsson; I Prokopenko

doi:10.1371/journal.pmed.1001474

The Role of Adiposity in Cardiometabolic Traits: A Mendelian Randomization Analysis

T Fall, S Hagg, R Magi, A Ploner, K (Kirsten) Fischer, M Horikoshi, AP Sarin, G Thorleifsson, C Ladenvall, M Kals, Maris Kuningas, HHM Draisma, JS Ried, NR van Zuydam, V Huikari, M Mangino, E Sonestedt, B Benyamin, CP Nelson, NV RiveraK Kristiansson, HY Shen, AS Havulinna, Abbas Dehghan, LA Donnelly, M Kaakinen, ML Nuotio, N Robertson, Renee Bruijn, Arfan Ikram, Najaf Amin, AJ Balmforth, PS Braund, ASF Doney, A Doring, P Elliott, T Esko, OH Franco Duran, S Gretarsdottir, AL Hartikainen, K Heikkila, KH Herzig, H Holm, JJ (Jouke Jan) Hottenga, E Hypponen, T Illig, Aaron Isaacs, B Isomaa, Lennart Karssen, J Kettunen, W Koenig, K Kuulasmaa, T Laatikainen, J Laitinen, C Lindgren, V Lyssenko, E Laara, NW Rayner, S Mannisto, A Pouta, W Rathmann, Fernando Rivadeneira, A Ruokonen, MJ Savolainen, E.J.G. Sijbrands, KS Small, JH Smit, V Steinthorsdottir, AC Syvanen, A Taanila, MD Tobin, André Uitterlinden, SM Willems, G Willemsen, JCM Witteman, M Perola, A Evans, J Ferrieres, J Virtamo, F Kee, DA Tregouet, D Arveiler, P Amouyel, MM Ferrario, P Brambilla, AS Hall, A Heath, PAF Madden, NG Martin, GW Montgomery, JB Whitfield, A Jula, P Knekt, Ben Oostra, Cornelia Duijn, BWJH Penninx, GD Smith, J Kaprio, NJ Samani, C Gieger, A Peters, HE Wichmann, DI Boomsma, EJC de Geus, T Tuomi, C Power, CJ Hammond, TD Spector, L Lind, M Orho-Melander, CNA Palmer, AD Morris, L Groop, MR Jarvelin, V Salomaa, E Vartiainen, Bert Hofman, S Ripatti, A Metspalu, U Thorsteinsdottir, K Stefansson, NL Pedersen, MI McCarthy, E Ingelsson, I Prokopenko

Research output: Contribution to journal › Article › Academic › peer-review

172 Citations (Scopus)

13 Downloads (Pure)

Original language	Undefined/Unknown
Journal	PLoS Medicine (print)
Volume	10
Issue number	6
DOIs	https://doi.org/10.1371/journal.pmed.1001474
Publication status	Published - 2013

Research programs

EMC COEUR-09
EMC MGC-02-96-01
EMC MM-01-39-09-A
EMC NIHES-01-64-02
EMC NIHES-03-30-02

Access to Document

10.1371/journal.pmed.1001474

journal.pmed.1001196.pdfFinal published version, 589 KB

http://hdl.handle.net/1765/55669

Cite this

Fall, T., Hagg, S., Magi, R., Ploner, A., Fischer, K., Horikoshi, M., Sarin, AP., Thorleifsson, G., Ladenvall, C., Kals, M., Kuningas, M., Draisma, HHM., Ried, JS., van Zuydam, NR., Huikari, V., Mangino, M., Sonestedt, E., Benyamin, B., Nelson, CP., ... Prokopenko, I. (2013). The Role of Adiposity in Cardiometabolic Traits: A Mendelian Randomization Analysis. PLoS Medicine (print), 10(6). https://doi.org/10.1371/journal.pmed.1001474

@article{f73861ce4a8d41c1bd1d092e6fa431c2,

title = "The Role of Adiposity in Cardiometabolic Traits: A Mendelian Randomization Analysis",

author = "T Fall and S Hagg and R Magi and A Ploner and Fischer, {K (Kirsten)} and M Horikoshi and AP Sarin and G Thorleifsson and C Ladenvall and M Kals and Maris Kuningas and HHM Draisma and JS Ried and {van Zuydam}, NR and V Huikari and M Mangino and E Sonestedt and B Benyamin and CP Nelson and NV Rivera and K Kristiansson and HY Shen and AS Havulinna and Abbas Dehghan and LA Donnelly and M Kaakinen and ML Nuotio and N Robertson and Renee Bruijn and Arfan Ikram and Najaf Amin and AJ Balmforth and PS Braund and ASF Doney and A Doring and P Elliott and T Esko and {Franco Duran}, OH and S Gretarsdottir and AL Hartikainen and K Heikkila and KH Herzig and H Holm and Hottenga, {JJ (Jouke Jan)} and E Hypponen and T Illig and Aaron Isaacs and B Isomaa and Lennart Karssen and J Kettunen and W Koenig and K Kuulasmaa and T Laatikainen and J Laitinen and C Lindgren and V Lyssenko and E Laara and NW Rayner and S Mannisto and A Pouta and W Rathmann and Fernando Rivadeneira and A Ruokonen and MJ Savolainen and E.J.G. Sijbrands and KS Small and JH Smit and V Steinthorsdottir and AC Syvanen and A Taanila and MD Tobin and Andr{\'e} Uitterlinden and SM Willems and G Willemsen and JCM Witteman and M Perola and A Evans and J Ferrieres and J Virtamo and F Kee and DA Tregouet and D Arveiler and P Amouyel and MM Ferrario and P Brambilla and AS Hall and A Heath and PAF Madden and NG Martin and GW Montgomery and JB Whitfield and A Jula and P Knekt and Ben Oostra and Cornelia Duijn and BWJH Penninx and GD Smith and J Kaprio and NJ Samani and C Gieger and A Peters and HE Wichmann and DI Boomsma and {de Geus}, EJC and T Tuomi and C Power and CJ Hammond and TD Spector and L Lind and M Orho-Melander and CNA Palmer and AD Morris and L Groop and MR Jarvelin and V Salomaa and E Vartiainen and Bert Hofman and S Ripatti and A Metspalu and U Thorsteinsdottir and K Stefansson and NL Pedersen and MI McCarthy and E Ingelsson and I Prokopenko",

year = "2013",

doi = "10.1371/journal.pmed.1001474",

language = "Undefined/Unknown",

volume = "10",

journal = "PLoS Medicine (print)",

issn = "1549-1277",

publisher = "Public Library of Science",

number = "6",

}

Fall, T, Hagg, S, Magi, R, Ploner, A, Fischer, K, Horikoshi, M, Sarin, AP, Thorleifsson, G, Ladenvall, C, Kals, M, Kuningas, M, Draisma, HHM, Ried, JS, van Zuydam, NR, Huikari, V, Mangino, M, Sonestedt, E, Benyamin, B, Nelson, CP, Rivera, NV, Kristiansson, K, Shen, HY, Havulinna, AS, Dehghan, A, Donnelly, LA, Kaakinen, M, Nuotio, ML, Robertson, N, Bruijn, R, Ikram, A , Amin, N, Balmforth, AJ, Braund, PS, Doney, ASF, Doring, A, Elliott, P, Esko, T, Franco Duran, OH, Gretarsdottir, S, Hartikainen, AL, Heikkila, K, Herzig, KH, Holm, H, Hottenga, JJ, Hypponen, E, Illig, T, Isaacs, A, Isomaa, B, Karssen, L, Kettunen, J, Koenig, W, Kuulasmaa, K, Laatikainen, T, Laitinen, J, Lindgren, C, Lyssenko, V, Laara, E, Rayner, NW, Mannisto, S, Pouta, A, Rathmann, W, Rivadeneira, F, Ruokonen, A, Savolainen, MJ, Sijbrands, EJG, Small, KS, Smit, JH, Steinthorsdottir, V, Syvanen, AC, Taanila, A, Tobin, MD, Uitterlinden, A, Willems, SM, Willemsen, G, Witteman, JCM, Perola, M, Evans, A, Ferrieres, J, Virtamo, J, Kee, F, Tregouet, DA, Arveiler, D, Amouyel, P, Ferrario, MM, Brambilla, P, Hall, AS, Heath, A, Madden, PAF, Martin, NG, Montgomery, GW, Whitfield, JB, Jula, A, Knekt, P, Oostra, B, Duijn, C, Penninx, BWJH, Smith, GD, Kaprio, J, Samani, NJ, Gieger, C, Peters, A, Wichmann, HE, Boomsma, DI, de Geus, EJC, Tuomi, T, Power, C, Hammond, CJ, Spector, TD, Lind, L, Orho-Melander, M, Palmer, CNA, Morris, AD, Groop, L, Jarvelin, MR, Salomaa, V, Vartiainen, E, Hofman, B, Ripatti, S, Metspalu, A, Thorsteinsdottir, U, Stefansson, K, Pedersen, NL, McCarthy, MI, Ingelsson, E & Prokopenko, I 2013, 'The Role of Adiposity in Cardiometabolic Traits: A Mendelian Randomization Analysis', PLoS Medicine (print), vol. 10, no. 6. https://doi.org/10.1371/journal.pmed.1001474

TY - JOUR

T1 - The Role of Adiposity in Cardiometabolic Traits: A Mendelian Randomization Analysis

AU - Fall, T

AU - Hagg, S

AU - Magi, R

AU - Ploner, A

AU - Fischer, K (Kirsten)

AU - Horikoshi, M

AU - Sarin, AP

AU - Thorleifsson, G

AU - Ladenvall, C

AU - Kals, M

AU - Kuningas, Maris

AU - Draisma, HHM

AU - Ried, JS

AU - van Zuydam, NR

AU - Huikari, V

AU - Mangino, M

AU - Sonestedt, E

AU - Benyamin, B

AU - Nelson, CP

AU - Rivera, NV

AU - Kristiansson, K

AU - Shen, HY

AU - Havulinna, AS

AU - Dehghan, Abbas

AU - Donnelly, LA

AU - Kaakinen, M

AU - Nuotio, ML

AU - Robertson, N

AU - Bruijn, Renee

AU - Ikram, Arfan

AU - Amin, Najaf

AU - Balmforth, AJ

AU - Braund, PS

AU - Doney, ASF

AU - Doring, A

AU - Elliott, P

AU - Esko, T

AU - Franco Duran, OH

AU - Gretarsdottir, S

AU - Hartikainen, AL

AU - Heikkila, K

AU - Herzig, KH

AU - Holm, H

AU - Hottenga, JJ (Jouke Jan)

AU - Hypponen, E

AU - Illig, T

AU - Isaacs, Aaron

AU - Isomaa, B

AU - Karssen, Lennart

AU - Kettunen, J

AU - Koenig, W

AU - Kuulasmaa, K

AU - Laatikainen, T

AU - Laitinen, J

AU - Lindgren, C

AU - Lyssenko, V

AU - Laara, E

AU - Rayner, NW

AU - Mannisto, S

AU - Pouta, A

AU - Rathmann, W

AU - Rivadeneira, Fernando

AU - Ruokonen, A

AU - Savolainen, MJ

AU - Sijbrands, E.J.G.

AU - Small, KS

AU - Smit, JH

AU - Steinthorsdottir, V

AU - Syvanen, AC

AU - Taanila, A

AU - Tobin, MD

AU - Uitterlinden, André

AU - Willems, SM

AU - Willemsen, G

AU - Witteman, JCM

AU - Perola, M

AU - Evans, A

AU - Ferrieres, J

AU - Virtamo, J

AU - Kee, F

AU - Tregouet, DA

AU - Arveiler, D

AU - Amouyel, P

AU - Ferrario, MM

AU - Brambilla, P

AU - Hall, AS

AU - Heath, A

AU - Madden, PAF

AU - Martin, NG

AU - Montgomery, GW

AU - Whitfield, JB

AU - Jula, A

AU - Knekt, P

AU - Oostra, Ben

AU - Duijn, Cornelia

AU - Penninx, BWJH

AU - Smith, GD

AU - Kaprio, J

AU - Samani, NJ

AU - Gieger, C

AU - Peters, A

AU - Wichmann, HE

AU - Boomsma, DI

AU - de Geus, EJC

AU - Tuomi, T

AU - Power, C

AU - Hammond, CJ

AU - Spector, TD

AU - Lind, L

AU - Orho-Melander, M

AU - Palmer, CNA

AU - Morris, AD

AU - Groop, L

AU - Jarvelin, MR

AU - Salomaa, V

AU - Vartiainen, E

AU - Hofman, Bert

AU - Ripatti, S

AU - Metspalu, A

AU - Thorsteinsdottir, U

AU - Stefansson, K

AU - Pedersen, NL

AU - McCarthy, MI

AU - Ingelsson, E

AU - Prokopenko, I

PY - 2013

Y1 - 2013

U2 - 10.1371/journal.pmed.1001474

DO - 10.1371/journal.pmed.1001474

M3 - Article

C2 - 23824655

SN - 1549-1277

VL - 10

JO - PLoS Medicine (print)

JF - PLoS Medicine (print)

IS - 6

ER -