The role of antibody-dependent enhancement in dengue vaccination

D. G. Aynekulu Mersha; I. van der Sterren; L. P.M. van Leeuwen; T. Langerak; M. S. Hakim; B. Martina; S. F.L. van Lelyveld; E. C.M. van Gorp

doi:10.1186/s40794-024-00231-2

The role of antibody-dependent enhancement in dengue vaccination

D. G. Aynekulu Mersha^*, I. van der Sterren, L. P.M. van Leeuwen, T. Langerak, M. S. Hakim, B. Martina, S. F.L. van Lelyveld, E. C.M. van Gorp

^*Corresponding author for this work

Virology

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Dengue is the most rapidly spreading vector-borne disease worldwide, with over half the global population at risk for an infection. Antibody-dependent enhancement (ADE) is associated with increased disease severity and may also be attributable to the deterioration of disease in vaccinated people. Two dengue vaccines are approved momentarily, with more in development. The increasing use of vaccines against dengue, combined with the development of more, makes a thorough understanding of the processes behind ADE more important than ever. Above that, due to the lack of treatment options, this method of prevention is of great importance. This review aims to explore the impact of ADE in dengue vaccinations, with the goal of enhancing potential vaccination strategies in the fight against dengue.

Original language	English
Article number	22
Journal	Tropical Diseases, Travel Medicine and Vaccines
Volume	10
Issue number	1
DOIs	https://doi.org/10.1186/s40794-024-00231-2
Publication status	Published - 1 Nov 2024

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Publisher Copyright: © The Author(s) 2024.

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Cite this

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title = "The role of antibody-dependent enhancement in dengue vaccination",

abstract = "Dengue is the most rapidly spreading vector-borne disease worldwide, with over half the global population at risk for an infection. Antibody-dependent enhancement (ADE) is associated with increased disease severity and may also be attributable to the deterioration of disease in vaccinated people. Two dengue vaccines are approved momentarily, with more in development. The increasing use of vaccines against dengue, combined with the development of more, makes a thorough understanding of the processes behind ADE more important than ever. Above that, due to the lack of treatment options, this method of prevention is of great importance. This review aims to explore the impact of ADE in dengue vaccinations, with the goal of enhancing potential vaccination strategies in the fight against dengue.",

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AU - Aynekulu Mersha, D. G.

AU - van der Sterren, I.

AU - van Leeuwen, L. P.M.

AU - Langerak, T.

AU - Hakim, M. S.

AU - Martina, B.

AU - van Lelyveld, S. F.L.

AU - van Gorp, E. C.M.

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AB - Dengue is the most rapidly spreading vector-borne disease worldwide, with over half the global population at risk for an infection. Antibody-dependent enhancement (ADE) is associated with increased disease severity and may also be attributable to the deterioration of disease in vaccinated people. Two dengue vaccines are approved momentarily, with more in development. The increasing use of vaccines against dengue, combined with the development of more, makes a thorough understanding of the processes behind ADE more important than ever. Above that, due to the lack of treatment options, this method of prevention is of great importance. This review aims to explore the impact of ADE in dengue vaccinations, with the goal of enhancing potential vaccination strategies in the fight against dengue.

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The role of antibody-dependent enhancement in dengue vaccination

Abstract

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