The role of distal tubular ion transport: In chronic kidney disease and calcineurin inhibition

Kuang-Yu Wei

The role of distal tubular ion transport: In chronic kidney disease and calcineurin inhibition

Kuang-Yu Wei

Internal Medicine

Research output: Types of Thesis › Doctoral Thesis › Internal

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Abstract

In this thesis the role of the distal tubule in chronic kidney disease (CKD) and calcineurin inhibition
was investigated.

The first part of the studies in this thesis aims to provide insights into how CKD, modeled by 5/6 nephrectomy, affects sodium transport along the nephron and disrupts both acute and chronic
responses to low and high dietary potassium. The "potassium switch" in the distal convoluted
tubules (DCT) of the kidney establishes a critical link between physiology and clinical medicine.
This phenomenon explains why the mechanisms involved in excreting an acute potassium load
also confer protection against hypertension, cardiovascular disease, and CKD.

The second part of this thesis focuses on the pharmacological effects of calcineurin inhibitors
(CNIs) on the distal tubules of the kidney, specifically the DCT and connecting tubules. The goal
is to compare the effects of the second-generation CNI voclosporin to those of the conventional
CNI tacrolimus.

Original language	English
Awarding Institution	Erasmus University Rotterdam
Supervisors/Advisors	Hoorn, Ewout, Supervisor Imenez Silva, Pedro, Co-supervisor
Award date	26 May 2026
Place of Publication	Rotterdam
Publisher	Erasmus University Rotterdam (EUR)
Print ISBNs	978-94-93539-20-4
Publication status	Published - 26 May 2026

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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final dissertation Wei, Kuang-YuFinal published version, 33.7 MB

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title = "The role of distal tubular ion transport: In chronic kidney disease and calcineurin inhibition",

abstract = "In this thesis the role of the distal tubule in chronic kidney disease (CKD) and calcineurin inhibition was investigated. The first part of the studies in this thesis aims to provide insights into how CKD, modeled by 5/6 nephrectomy, affects sodium transport along the nephron and disrupts both acute and chronic responses to low and high dietary potassium. The {"}potassium switch{"} in the distal convoluted tubules (DCT) of the kidney establishes a critical link between physiology and clinical medicine. This phenomenon explains why the mechanisms involved in excreting an acute potassium load also confer protection against hypertension, cardiovascular disease, and CKD. The second part of this thesis focuses on the pharmacological effects of calcineurin inhibitors (CNIs) on the distal tubules of the kidney, specifically the DCT and connecting tubules. The goal is to compare the effects of the second-generation CNI voclosporin to those of the conventional CNI tacrolimus. ",

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T2 - In chronic kidney disease and calcineurin inhibition

AU - Wei, Kuang-Yu

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N2 - In this thesis the role of the distal tubule in chronic kidney disease (CKD) and calcineurin inhibition was investigated. The first part of the studies in this thesis aims to provide insights into how CKD, modeled by 5/6 nephrectomy, affects sodium transport along the nephron and disrupts both acute and chronic responses to low and high dietary potassium. The "potassium switch" in the distal convoluted tubules (DCT) of the kidney establishes a critical link between physiology and clinical medicine. This phenomenon explains why the mechanisms involved in excreting an acute potassium load also confer protection against hypertension, cardiovascular disease, and CKD. The second part of this thesis focuses on the pharmacological effects of calcineurin inhibitors (CNIs) on the distal tubules of the kidney, specifically the DCT and connecting tubules. The goal is to compare the effects of the second-generation CNI voclosporin to those of the conventional CNI tacrolimus.

AB - In this thesis the role of the distal tubule in chronic kidney disease (CKD) and calcineurin inhibition was investigated. The first part of the studies in this thesis aims to provide insights into how CKD, modeled by 5/6 nephrectomy, affects sodium transport along the nephron and disrupts both acute and chronic responses to low and high dietary potassium. The "potassium switch" in the distal convoluted tubules (DCT) of the kidney establishes a critical link between physiology and clinical medicine. This phenomenon explains why the mechanisms involved in excreting an acute potassium load also confer protection against hypertension, cardiovascular disease, and CKD. The second part of this thesis focuses on the pharmacological effects of calcineurin inhibitors (CNIs) on the distal tubules of the kidney, specifically the DCT and connecting tubules. The goal is to compare the effects of the second-generation CNI voclosporin to those of the conventional CNI tacrolimus.

M3 - Doctoral Thesis

SN - 978-94-93539-20-4

PB - Erasmus University Rotterdam (EUR)

CY - Rotterdam

ER -

The role of distal tubular ion transport: In chronic kidney disease and calcineurin inhibition

Abstract

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