The role of IL-23 and CCR6+ memory T helper cells in healthy and inflammatory arthritis conditions

Research output: Types of ThesisDoctoral ThesisInternal

2 Downloads (Pure)


Interleukin 23 (IL-23) is a pro-inflammatory cytokine, which is secreted by activated
dendritic cells and macrophages, which are located in peripheral tissues such as the
intestinal mucosa, skin and the joints. Once secreted, IL-23 binds to the IL-23 receptor
(IL-23R) on its target cells to induce the production of other pro-inflammatory cytokines,
such as IL-17A, IL-22, TNFα. These cytokines can also stimulate the production of other
pro-inflammatory cytokines, anti-microbial peptides and chemokines, for instance for
control of infections.
In addition to its contribution in fighting pathogens that can cause infections, IL-23
can also affect bone remodeling during physiological condition. This is made possible
through (in)direct interactions of IL-23 with several immune and non-immune cells,
such as osteoblasts (bone forming cells) and osteoclasts (bone resorbing cells).

This thesis consists of two parts. In part I, we focused on the effects of IL-23/IL-23R
signaling under healthy conditions on CCR6+ memory T helper (Th) cells, one of the
target cells of IL-23, and the precursors of osteoclasts (chapter 4). Also, the role of IL-23R signaling was investigated in physiological bone remodeling (chapter 3).

In part II, the focus was on the role of IL-23/IL-23R signaling and its target cells, the
CCR6+ Th cells, during inflammatory arthritis (IA). Inflammatory arthritis is a broad
term used for several conditions in which an abnormal immune response leads to joint
inflammation. This thesis focuses on rheumatoid arthritis (RA) and psoriatic arthritis
Original languageEnglish
Awarding Institution
  • Erasmus University Rotterdam
  • Lubberts, Erik, Supervisor
  • Hazes, Mieke, Supervisor
Award date5 Jul 2024
Place of PublicationRotterdam
Print ISBNs978-94-6469-902-9
Publication statusPublished - 5 Jul 2024


Dive into the research topics of 'The role of IL-23 and CCR6+ memory T helper cells in healthy and inflammatory arthritis conditions'. Together they form a unique fingerprint.

Cite this