The role of melatonin treatment in chronic kidney disease

M Russcher; B Koch; E Nagtegaal; K van der Putten; P Ter Wee; C Gaillard

doi:10.2741/4075

The role of melatonin treatment in chronic kidney disease

M Russcher, B Koch, E Nagtegaal, K van der Putten, P Ter Wee, C Gaillard

Research output: Contribution to journal › Article › Academic › peer-review

51 Citations (Scopus)

Abstract

The pineal hormone melatonin plays a major role in circadian sleep-wake rhythm. Patients with Chronic Kidney Disease (CKD), especially those who are on hemodialysis, frequently suffer from sleep disturbances. In this review an overview is given of the classification of stages of chronic kidney disease, followed by a presentation of the circadian rhythm disorders in renal disease involving sleep disturbances in relation to melatonin deficiency. The therapeutic benefit of melatonin treatment in sleep disorders related to chronic kidney disease including the controlled trials solving this topic, is described. Furthermore, the beneficial effect of melatonin on blood pressure alterations in CKD states and the protection of melatonin in oxidative stress and inflammation in renal disorders are explored. Finally a hypothetic model is described for the relation between circadian rhythm disorders and CKD.

Original language	Undefined/Unknown
Pages (from-to)	2644-2656
Number of pages	13
Journal	Frontiers in Bioscience
Volume	17
DOIs	https://doi.org/10.2741/4075
Publication status	Published - 2012
Externally published	Yes

Research programs

EMC OR-01-34-01

Access to Document

10.2741/4075

http://hdl.handle.net/1765/75090

Cite this

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title = "The role of melatonin treatment in chronic kidney disease",

abstract = "The pineal hormone melatonin plays a major role in circadian sleep-wake rhythm. Patients with Chronic Kidney Disease (CKD), especially those who are on hemodialysis, frequently suffer from sleep disturbances. In this review an overview is given of the classification of stages of chronic kidney disease, followed by a presentation of the circadian rhythm disorders in renal disease involving sleep disturbances in relation to melatonin deficiency. The therapeutic benefit of melatonin treatment in sleep disorders related to chronic kidney disease including the controlled trials solving this topic, is described. Furthermore, the beneficial effect of melatonin on blood pressure alterations in CKD states and the protection of melatonin in oxidative stress and inflammation in renal disorders are explored. Finally a hypothetic model is described for the relation between circadian rhythm disorders and CKD.",

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AU - Russcher, M

AU - Koch, B

AU - Nagtegaal, E

AU - van der Putten, K

AU - Ter Wee, P

AU - Gaillard, C

PY - 2012

Y1 - 2012

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AB - The pineal hormone melatonin plays a major role in circadian sleep-wake rhythm. Patients with Chronic Kidney Disease (CKD), especially those who are on hemodialysis, frequently suffer from sleep disturbances. In this review an overview is given of the classification of stages of chronic kidney disease, followed by a presentation of the circadian rhythm disorders in renal disease involving sleep disturbances in relation to melatonin deficiency. The therapeutic benefit of melatonin treatment in sleep disorders related to chronic kidney disease including the controlled trials solving this topic, is described. Furthermore, the beneficial effect of melatonin on blood pressure alterations in CKD states and the protection of melatonin in oxidative stress and inflammation in renal disorders are explored. Finally a hypothetic model is described for the relation between circadian rhythm disorders and CKD.

U2 - 10.2741/4075

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JO - Frontiers in Bioscience

JF - Frontiers in Bioscience

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