Abstract
Ribosomes are essential nanomachines responsible for all protein production in cells. Ribosome biogenesis and function are energy costly processes, they are tightly regulated to match cellular needs. In cancer, major pathways that control ribosome biogenesis and function are often deregulated to ensure cell survival and to accommodate the continuous proliferation of tumour cells. Ribosomal RNAs (rRNAs) are abundantly modified with 2'-O-methylation (Nm, ribomethylation) being one of the most common modifications. In eukaryotic ribosomes, ribomethylation is performed by the methyltransferase Fibrillarin guided by box C/D small nucleolar RNAs (snoRNAs). Accumulating evidences indicate that snoRNA expression and ribosome methylation profiles are altered in cancer. Here we review our current knowledge on differential snoRNA expression and rRNA 2ʹ-O methylation in the context of human malignancies, and discuss the consequences and opportunities for cancer diagnostics, prognostics, and therapeutics.
| Original language | English |
|---|---|
| Pages (from-to) | 61-74 |
| Number of pages | 14 |
| Journal | RNA Biology |
| Volume | 18 |
| Issue number | S1 |
| DOIs | |
| Publication status | Published - 14 Nov 2021 |
Bibliographical note
Funding Information:The preparation of this review was a collaborative effort of members of the COST Action CA16120 - European Epitranscriptomics Network - EPITRAN https://www.cost.eu/actions/CA16120/; https://epitran.eu/ and was supported by a PhD fellowship FCT - Fundação para a Ciência e Tecnologia fundação para a ciência e a tecnologia SFRH/BD/136007/2018</#AWARD-ID;>, and an EUR fellowship Erasmus Universiteit Rotterdam 2018-CvB/RE/PJ/RA00279215. DLJL Lab is supported by the Fonds de la Recherche Scientifique ((F.R.S./FNRS), the Université Libre de Bruxelles (ULB), the Région Wallone, and the European Joint Programme on Rare Diseases (EJP-RD). Fig. 1 was generated using Jmol: an open-source Java viewer for chemical structures in 3D. http://www.jmol.org/. Figs. 2 and 3 were created using BioRender (https://biorender.com/).
Publisher Copyright:
© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
