The role of phospho-tyrosine signaling in platelet biology and hemostasis

Alessandra Sousa Faria, SS Andrade, Maikel Peppelenbosch, CV Ferreira-Halder, Gwenny Fuhler

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5 Citations (Scopus)
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Platelets are small enucleated cell fragments specialized in the control of hemostasis, but also playing a role in angiogenesis, inflammation and immunity. This plasticity demands a broad range of physiological processes. Platelet functions are mediated through a variety of receptors, the concerted action of which must be tightly regulated, in order to allow specific and timely responses to different stimuli. Protein phosphorylation is one of the main key regulatory mechanisms by which extracellular signals are conveyed. Despite the importance of platelets in health and disease, the molecular pathways underlying the activation of these cells are still under investigation. Here, we review current literature on signaling platelet biology and in particular emphasize the newly emerging role of phosphatases in these processes.

Original languageEnglish
Article number118927
JournalBiochimica et Biophysica Acta - Molecular Cell Research
Issue number3
Publication statusPublished - Mar 2021

Bibliographical note

Funding Information:
This study was supported by the Sao Paulo Research Foundation under grants AVSF ( 2017/08119-8 and 2018/00736-0 ), SSA ( 2016/14459-3 and 2017/26317-1 ) and CVFH ( 2015/20412-7 ), and the authors would like to thank the National Council for Scientific and Technological Development (CNPq) - Brazil. This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) - Finance Code 001 .

Publisher Copyright:
© 2020

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