The Social Behavioral Phenotype in Boys and Girls with an Extra X Chromosome (Klinefelter Syndrome and Trisomy X): A Comparison with Autism Spectrum Disorder

S van Rijn; L Stockmann; M Borghgraef; H Bruining; C van Ravenswaaij-Arts; K Hansson; H Swaab; LCP Govaerts

doi:10.1007/s10803-013-1860-5

The Social Behavioral Phenotype in Boys and Girls with an Extra X Chromosome (Klinefelter Syndrome and Trisomy X): A Comparison with Autism Spectrum Disorder

S van Rijn, L Stockmann, M Borghgraef, H Bruining, C van Ravenswaaij-Arts, K Hansson, H Swaab, LCP Govaerts

Clinical Genetics

Research output: Contribution to journal › Article › Academic › peer-review

60 Citations (Scopus)

Abstract

The present study aimed to gain more insight in the social behavioral phenotype, and related autistic symptomatology, of children with an extra X chromosome in comparison to children with ASD. Participants included 60 children with an extra X chromosome (34 boys with Klinefelter syndrome and 26 girls with Trisomy X), 58 children with ASD and 106 controls, aged 9 to 18 years. We used the Autism Diagnostic Interview, Social Responsiveness Scale, Social Anxiety Scale and Social Skills Rating System. In the extra X group, levels of social dysfunction and autism symptoms were increased, being in between controls and ASD. In contrast to the ASD group, the extra X group showed increased social anxiety. The effects were similar for boys and girls with an extra X chromosome.

Original language	Undefined/Unknown
Pages (from-to)	310-320
Number of pages	11
Journal	Journal of Autism and Developmental Disorders
Volume	44
Issue number	2
DOIs	https://doi.org/10.1007/s10803-013-1860-5
Publication status	Published - 2014

Research programs

EMC MGC-02-96-01

Access to Document

10.1007/s10803-013-1860-5

http://hdl.handle.net/1765/71846

Cite this

van Rijn, S., Stockmann, L., Borghgraef, M., Bruining, H., van Ravenswaaij-Arts, C., Hansson, K., Swaab, H., & Govaerts, LCP. (2014). The Social Behavioral Phenotype in Boys and Girls with an Extra X Chromosome (Klinefelter Syndrome and Trisomy X): A Comparison with Autism Spectrum Disorder. Journal of Autism and Developmental Disorders, 44(2), 310-320. https://doi.org/10.1007/s10803-013-1860-5

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abstract = "The present study aimed to gain more insight in the social behavioral phenotype, and related autistic symptomatology, of children with an extra X chromosome in comparison to children with ASD. Participants included 60 children with an extra X chromosome (34 boys with Klinefelter syndrome and 26 girls with Trisomy X), 58 children with ASD and 106 controls, aged 9 to 18 years. We used the Autism Diagnostic Interview, Social Responsiveness Scale, Social Anxiety Scale and Social Skills Rating System. In the extra X group, levels of social dysfunction and autism symptoms were increased, being in between controls and ASD. In contrast to the ASD group, the extra X group showed increased social anxiety. The effects were similar for boys and girls with an extra X chromosome.",

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van Rijn, S, Stockmann, L, Borghgraef, M, Bruining, H, van Ravenswaaij-Arts, C, Hansson, K, Swaab, H & Govaerts, LCP 2014, 'The Social Behavioral Phenotype in Boys and Girls with an Extra X Chromosome (Klinefelter Syndrome and Trisomy X): A Comparison with Autism Spectrum Disorder', Journal of Autism and Developmental Disorders, vol. 44, no. 2, pp. 310-320. https://doi.org/10.1007/s10803-013-1860-5

The Social Behavioral Phenotype in Boys and Girls with an Extra X Chromosome (Klinefelter Syndrome and Trisomy X): A Comparison with Autism Spectrum Disorder. / van Rijn, S; Stockmann, L; Borghgraef, M et al.
In: Journal of Autism and Developmental Disorders, Vol. 44, No. 2, 2014, p. 310-320.

Research output: Contribution to journal › Article › Academic › peer-review

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