The spliceosome as target for anticancer treatment

RJ (Robbert) van Alphen, Erik Wiemer, Herman Burger, Ferry Eskens

Research output: Contribution to journalArticleAcademicpeer-review

81 Citations (Scopus)

Abstract

The spliceosome is a ribonucleoprotein complex involved in RNA splicing, that is, the removal of non-coding introns from precursor messenger RNA. (Alternative) Splicing events may play an essential role in tumourigenesis. The recent discovery that the spliceosome is a target for novel compounds with anticancer activity opens up new therapeutic avenues.
Original languageUndefined/Unknown
Pages (from-to)228-232
Number of pages5
JournalBritish Journal of Cancer
Volume100
Issue number2
DOIs
Publication statusPublished - 2009

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