The structural disconnectome: A pathology-sensitive extension of the structural connectome

Carolyn Langen, Meike Vernooij, Lotte Cremers, Wyke Huizinga, Marius de Groot, Arfan Ikram, Tonya White, Wiro Niessen

Research output: Chapter/Conference proceedingConference proceedingAcademicpeer-review

3 Citations (Scopus)

Abstract

Brain connectivity is increasingly being studied using connectomes. Typical structural connectome definitions do not directly take white matter pathology into account. Presumably, pathology impedes signal transmission along fibres, leading to a reduction in function. In order to directly study disconnection and localize pathology within the connectome, we present the disconnectome, which only considers fibres that intersect with white matter pathology. To show the potential of the disconnectome in brain studies, we showed in a cohort of 4199 adults with varying loads of white matter lesions (WMLs) that: (1) Disconnection is not a function of streamline density; (2) Hubs are more affected by WMLs than peripheral nodes; (3) Connections between hubs are more severely and frequently affected by WMLs than other connection types; and (4) Connections between region clusters are often more severely affected than those within clusters.
Original languageEnglish
Title of host publication2017 IEEE 14th International Symposium on Biomedical Imaging, ISBI 2017
Place of PublicationNew York
PublisherIEEE Computer Society
Pages366-370
Number of pages5
ISBN (Electronic)9781509011711
ISBN (Print)9781509011728
DOIs
Publication statusPublished - 15 Jun 2017
Event4th IEEE International Symposium on Biomedical Imaging, ISBI 2017 - Melbourne, Australia
Duration: 18 Apr 201721 Apr 2017

Publication series

SeriesProceedings - International Symposium on Biomedical Imaging
ISSN1945-7928

Conference

Conference4th IEEE International Symposium on Biomedical Imaging, ISBI 2017
Period18/04/1721/04/17

Bibliographical note

ISI Document Delivery No.: BI7JM Times Cited: 0 Cited Reference Count: 20

Research programs

  • EMC NIHES-03-30-02

Fingerprint

Dive into the research topics of 'The structural disconnectome: A pathology-sensitive extension of the structural connectome'. Together they form a unique fingerprint.

Cite this