The symphony of cacophony: understanding the order in neurodegenerative diseases

Vikram Venkatraghavan

Research output: Types of ThesisDoctoral ThesisInternal

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Neurodegenerative diseases such as Alzheimer's disease are notoriously heterogeneous; pathologically as well as in their clinical presentation in patients. There are differences between patients in terms of the pathways of progression, the speed of progression, and the effect the progression has on the patient's cognition. This myriad of differences not only makes clinical diagnosis very challenging, but also has major implications for the efficacy of drug trials. As heterogeneous as these diseases are, there is an underlying order in their progression. An underlying method to their disruption of homeostasis. An underlying symphony leading to the cacophony.
Original languageEnglish
Awarding Institution
  • Erasmus University Rotterdam
  • Niessen, Wiro, Supervisor
  • Klein, Stefan, Co-supervisor
  • Bron, Esther, Co-supervisor
Award date8 Jun 2021
Print ISBNs9789464232486
Publication statusPublished - 8 Jun 2021

Bibliographical note

This work has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 666992 and from TKI-LSH Health Holland Alzheimer Nederland project (No. LSHM18049)


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