The symphony of cacophony: understanding the order in neurodegenerative diseases

Vikram Venkatraghavan

The symphony of cacophony: understanding the order in neurodegenerative diseases

Vikram Venkatraghavan

Radiology & Nuclear Medicine

Research output: Types of Thesis › Doctoral Thesis › Internal

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Abstract

Neurodegenerative diseases such as Alzheimer's disease are notoriously heterogeneous; pathologically as well as in their clinical presentation in patients. There are differences between patients in terms of the pathways of progression, the speed of progression, and the effect the progression has on the patient's cognition. This myriad of differences not only makes clinical diagnosis very challenging, but also has major implications for the efficacy of drug trials. As heterogeneous as these diseases are, there is an underlying order in their progression. An underlying method to their disruption of homeostasis. An underlying symphony leading to the cacophony.

Original language	English
Awarding Institution	Erasmus University Rotterdam
Supervisors/Advisors	Niessen, Wiro, Supervisor Klein, Stefan, Co-supervisor Bron, Esther, Co-supervisor
Award date	8 Jun 2021
Print ISBNs	9789464232486
Publication status	Published - 8 Jun 2021

Bibliographical note

This work has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 666992 and from TKI-LSH Health Holland Alzheimer Nederland project (No. LSHM18049)

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title = "The symphony of cacophony: understanding the order in neurodegenerative diseases",

abstract = "Neurodegenerative diseases such as Alzheimer's disease are notoriously heterogeneous; pathologically as well as in their clinical presentation in patients. There are differences between patients in terms of the pathways of progression, the speed of progression, and the effect the progression has on the patient's cognition. This myriad of differences not only makes clinical diagnosis very challenging, but also has major implications for the efficacy of drug trials. As heterogeneous as these diseases are, there is an underlying order in their progression. An underlying method to their disruption of homeostasis. An underlying symphony leading to the cacophony.",

author = "Vikram Venkatraghavan",

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T2 - understanding the order in neurodegenerative diseases

AU - Venkatraghavan, Vikram

N1 - This work has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 666992 and from TKI-LSH Health Holland Alzheimer Nederland project (No. LSHM18049)

PY - 2021/6/8

Y1 - 2021/6/8

N2 - Neurodegenerative diseases such as Alzheimer's disease are notoriously heterogeneous; pathologically as well as in their clinical presentation in patients. There are differences between patients in terms of the pathways of progression, the speed of progression, and the effect the progression has on the patient's cognition. This myriad of differences not only makes clinical diagnosis very challenging, but also has major implications for the efficacy of drug trials. As heterogeneous as these diseases are, there is an underlying order in their progression. An underlying method to their disruption of homeostasis. An underlying symphony leading to the cacophony.

AB - Neurodegenerative diseases such as Alzheimer's disease are notoriously heterogeneous; pathologically as well as in their clinical presentation in patients. There are differences between patients in terms of the pathways of progression, the speed of progression, and the effect the progression has on the patient's cognition. This myriad of differences not only makes clinical diagnosis very challenging, but also has major implications for the efficacy of drug trials. As heterogeneous as these diseases are, there is an underlying order in their progression. An underlying method to their disruption of homeostasis. An underlying symphony leading to the cacophony.

UR - http://hdl.handle.net/1765/135552

M3 - Doctoral Thesis

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T3 - ASCI Dissertation Series

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The symphony of cacophony: understanding the order in neurodegenerative diseases

Abstract

Bibliographical note

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