The synthetic synergistic cinnamon oil cin-102 is active against madurella mycetomatis, the most common causative agent of mycetoma

Mickey Konings, Kimberly Eadie, Wilson Lim, Ahmed H. Fahal, Johan Mouton, Nicolas Tesse, Wendy W.J. van de Sande*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)
22 Downloads (Pure)

Abstract

Mycetoma is a devastating neglected tropical infection of the subcutaneous tissue and most commonly caused by the fungus Madurella mycetomatis. Treatment of mycetoma consists of a combination of a long term antifungal treatment with itraconazole and sur-gery. However, treatment is associated with low success rates. Therefore, there is a need to identify novel treatments for mycetoma. CIN-102 is a synthetic partial copy of cinnamon oils with activity against many pathogenic bacteria and fungi. In this study we determined the in vitro activity of CIN-102 against 21 M. mycetomatis isolates and its in vivo efficacy in a M. mycetomatis infected Galleria mellonella larval model. In vitro, CIN-102 was active against M. mycetomatis with MICs ranging from 32 μg/mL to 512 μg/mL. 128 μg/mL was needed to inhibit the growth in 50% of tested isolates. In vivo, concentrations below the MIC of 40 mg/kg and 80 mg/kg CIN-102 prolonged larval survival, but higher concentrations of CIN-102 did not.

Original languageEnglish
Article numbere0009488
JournalPLoS Neglected Tropical Diseases
Volume15
Issue number6
DOIs
Publication statusPublished - 9 Jun 2021

Bibliographical note

Funding Information:
This study was supported by Septeos. The funders had no role in study design, data collection and analysis, nor the decision to publish.

Publisher Copyright:
© 2021 Konings et al.

Fingerprint

Dive into the research topics of 'The synthetic synergistic cinnamon oil cin-102 is active against madurella mycetomatis, the most common causative agent of mycetoma'. Together they form a unique fingerprint.

Cite this