TY - JOUR
T1 - The synthetic synergistic cinnamon oil cin-102 is active against madurella mycetomatis, the most common causative agent of mycetoma
AU - Konings, Mickey
AU - Eadie, Kimberly
AU - Lim, Wilson
AU - Fahal, Ahmed H.
AU - Mouton, Johan
AU - Tesse, Nicolas
AU - van de Sande, Wendy W.J.
N1 - Funding Information:
This study was supported by Septeos. The funders had no role in study design, data collection and analysis, nor the decision to publish.
Publisher Copyright:
© 2021 Konings et al.
PY - 2021/6/9
Y1 - 2021/6/9
N2 - Mycetoma is a devastating neglected tropical infection of the subcutaneous tissue and most commonly caused by the fungus Madurella mycetomatis. Treatment of mycetoma consists of a combination of a long term antifungal treatment with itraconazole and sur-gery. However, treatment is associated with low success rates. Therefore, there is a need to identify novel treatments for mycetoma. CIN-102 is a synthetic partial copy of cinnamon oils with activity against many pathogenic bacteria and fungi. In this study we determined the in vitro activity of CIN-102 against 21 M. mycetomatis isolates and its in vivo efficacy in a M. mycetomatis infected Galleria mellonella larval model. In vitro, CIN-102 was active against M. mycetomatis with MICs ranging from 32 μg/mL to 512 μg/mL. 128 μg/mL was needed to inhibit the growth in 50% of tested isolates. In vivo, concentrations below the MIC of 40 mg/kg and 80 mg/kg CIN-102 prolonged larval survival, but higher concentrations of CIN-102 did not.
AB - Mycetoma is a devastating neglected tropical infection of the subcutaneous tissue and most commonly caused by the fungus Madurella mycetomatis. Treatment of mycetoma consists of a combination of a long term antifungal treatment with itraconazole and sur-gery. However, treatment is associated with low success rates. Therefore, there is a need to identify novel treatments for mycetoma. CIN-102 is a synthetic partial copy of cinnamon oils with activity against many pathogenic bacteria and fungi. In this study we determined the in vitro activity of CIN-102 against 21 M. mycetomatis isolates and its in vivo efficacy in a M. mycetomatis infected Galleria mellonella larval model. In vitro, CIN-102 was active against M. mycetomatis with MICs ranging from 32 μg/mL to 512 μg/mL. 128 μg/mL was needed to inhibit the growth in 50% of tested isolates. In vivo, concentrations below the MIC of 40 mg/kg and 80 mg/kg CIN-102 prolonged larval survival, but higher concentrations of CIN-102 did not.
UR - http://www.scopus.com/inward/record.url?scp=85109116075&partnerID=8YFLogxK
U2 - 10.1371/journal.pntd.0009488
DO - 10.1371/journal.pntd.0009488
M3 - Article
C2 - 34106933
AN - SCOPUS:85109116075
SN - 1935-2727
VL - 15
JO - PLoS Neglected Tropical Diseases
JF - PLoS Neglected Tropical Diseases
IS - 6
M1 - e0009488
ER -
