TY - JOUR
T1 - The temporal association between social isolation, distress, and psychotic experiences in individuals at clinical high-risk for psychosis
AU - Akcaoglu, Zeynep
AU - Vaessen, Thomas
AU - Velthorst, Eva
AU - Lafit, Ginette
AU - Achterhof, Robin
AU - Nelson, Barnaby
AU - McGorry, Patrick
AU - Schirmbeck, Frederike
AU - Morgan, Craig
AU - Hartmann, Jessica
AU - Van Der Gaag, Mark
AU - De Haan, Lieuwe
AU - Valmaggia, Lucia
AU - McGuire, Philip
AU - Kempton, Matthew
AU - Steinhart, Henrietta
AU - Klippel, Annelie
AU - Viechtbauer, Wolfgang
AU - Batink, Tim
AU - Van Winkel, Ruud
AU - Van Amelsvoort, Thérèse
AU - Marcelis, Machteld
AU - Van Aubel, Evelyne
AU - Reininghaus, Ulrich
AU - Myin-Germeys, Inez
N1 - Publisher Copyright:
Copyright © The Author(s), 2024. Published by Cambridge University Press.
PY - 2024/1/5
Y1 - 2024/1/5
N2 - Background:Psychotic experiences (PEs) and social isolation (SI) seem related during early stages of psychosis, but the temporal dynamics between the two are not clear. Literature so far suggests a self-perpetuating cycle wherein momentary increases in PEs lead to social withdrawal, which, subsequently, triggers PEs at a next point in time, especially when SI is associated with increased distress. The current study investigated the daily-life temporal associations between SI and PEs, as well as the role of SI-related and general affective distress in individuals at clinical high risk (CHR) for psychosis. Methods: We used experience sampling methodology in a sample of 137 CHR participants. We analyzed the association between SI, PEs, and distress using time-lagged linear mixed-effects models. Results: SI did not predict next-moment fluctuations in PEs, or vice versa. Furthermore, although SI-related distress was not predictive of subsequent PEs, general affective distress during SI was a robust predictor of next-moment PEs. Conclusions: Our results suggest that SI and PEs are not directly related on a moment-to-moment level, but a negative emotional state when alone does contribute to the risk of PEs. These findings highlight the role of affective wellbeing during early-stage psychosis development.
AB - Background:Psychotic experiences (PEs) and social isolation (SI) seem related during early stages of psychosis, but the temporal dynamics between the two are not clear. Literature so far suggests a self-perpetuating cycle wherein momentary increases in PEs lead to social withdrawal, which, subsequently, triggers PEs at a next point in time, especially when SI is associated with increased distress. The current study investigated the daily-life temporal associations between SI and PEs, as well as the role of SI-related and general affective distress in individuals at clinical high risk (CHR) for psychosis. Methods: We used experience sampling methodology in a sample of 137 CHR participants. We analyzed the association between SI, PEs, and distress using time-lagged linear mixed-effects models. Results: SI did not predict next-moment fluctuations in PEs, or vice versa. Furthermore, although SI-related distress was not predictive of subsequent PEs, general affective distress during SI was a robust predictor of next-moment PEs. Conclusions: Our results suggest that SI and PEs are not directly related on a moment-to-moment level, but a negative emotional state when alone does contribute to the risk of PEs. These findings highlight the role of affective wellbeing during early-stage psychosis development.
UR - https://www.scopus.com/pages/publications/85183039490
U2 - 10.1017/s0033291723003598
DO - 10.1017/s0033291723003598
M3 - Article
C2 - 38179659
AN - SCOPUS:85183039490
SN - 0033-2917
VL - 54
SP - 1684
EP - 1692
JO - Psychological Medicine
JF - Psychological Medicine
IS - 8
ER -
