The Toronto Adolescent and Youth Cohort Study: Study Design and Early Data Related to Psychosis Spectrum Symptoms, Functioning, and Suicidality

Kristin Cleverley; George Foussias; TAY Cohort Study Team; Stephanie H Ameis; Darren B Courtney; Benjamin I Goldstein; Lisa D Hawke; Nicole Kozloff; Lena C Quilty; Martin Rotenberg; Anne L Wheeler; Brendan F Andrade; Madison Aitken; Don Mahleka; Melanie Jani; Margot Frayne; Jimmy K Y Wong; Rachel Kelly; Erin W Dickie; Daniel Felsky; John D Haltigan; Meng-Chuan Lai; Yuliya S Nikolova; Wanda Tempelaar; Wei Wang; Marco Battaglia; Muhammad Omair Husain; Sean Kidd; Paul Kurdyak; Robert D Levitan; Stephen P Lewis; Alexia Polillo; Peter Szatmari; Anna I R van der Miesen; Masoud Ahmadzadasl; Aristotle N Voineskos

doi:10.1016/j.bpsc.2023.10.011

The Toronto Adolescent and Youth Cohort Study: Study Design and Early Data Related to Psychosis Spectrum Symptoms, Functioning, and Suicidality

Kristin Cleverley, George Foussias, TAY Cohort Study Team, Stephanie H Ameis, Darren B Courtney, Benjamin I Goldstein, Lisa D Hawke, Nicole Kozloff, Lena C Quilty, Martin Rotenberg, Anne L Wheeler, Brendan F Andrade, Madison Aitken, Don Mahleka, Melanie Jani, Margot Frayne, Jimmy K Y Wong, Rachel Kelly, Erin W Dickie, Daniel FelskyJohn D Haltigan, Meng-Chuan Lai, Yuliya S Nikolova, Wanda Tempelaar, Wei Wang, Marco Battaglia, Muhammad Omair Husain, Sean Kidd, Paul Kurdyak, Robert D Levitan, Stephen P Lewis, Alexia Polillo, Peter Szatmari, Anna I R van der Miesen, Masoud Ahmadzadasl, Aristotle N Voineskos^*

^*Corresponding author for this work

Department of Technology and Operations Management

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

BACKGROUND:

Psychosis spectrum symptoms (PSSs) occur in a sizable percentage of youth and are associated with poorer cognitive performance, poorer functioning, and suicidality (i.e., suicidal thoughts and behaviors). PSSs may occur more frequently in youths already experiencing another mental illness, but the antecedents are not well known. The Toronto Adolescent and Youth (TAY) Cohort Study aims to characterize developmental trajectories in youths with mental illness and understand associations with PSSs, functioning, and suicidality.

METHODS:

The TAY Cohort Study is a longitudinal cohort study that aims to assess 1500 youths (age 11-24 years) presenting to tertiary care. In this article, we describe the extensive diagnostic and clinical characterization of psychopathology, substance use, functioning, suicidality, and health service utilization in these youths, with follow-up every 6 months over 5 years, including early baseline data.

RESULTS:

A total of 417 participants were enrolled between May 4, 2021, and February 2, 2023. Participants met diagnostic criteria for an average of 3.5 psychiatric diagnoses, most frequently anxiety and depressive disorders. Forty-nine percent of participants met a pre-established threshold for PSSs and exhibited higher rates of functional impairment, internalizing and externalizing symptoms, and suicidality than participants without PSSs.

CONCLUSIONS:

Initial findings from the TAY Cohort Study demonstrate the feasibility of extensive clinical phenotyping in youths who are seeking help for mental health problems. PSS prevalence is much higher than in community-based studies. Our early data support the critical need to better understand longitudinal trajectories of clinical youth cohorts in relation to psychosis risk, functioning, and suicidality.

Original language	English
Pages (from-to)	253-264
Number of pages	12
Journal	Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
Volume	9
Issue number	3
DOIs	https://doi.org/10.1016/j.bpsc.2023.10.011
Publication status	Published - Mar 2024

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Publisher Copyright:
© 2023 Society of Biological Psychiatry

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Cleverley, K., Foussias, G., TAY Cohort Study Team, Ameis, S. H., Courtney, D. B., Goldstein, B. I., Hawke, L. D., Kozloff, N., Quilty, L. C., Rotenberg, M., Wheeler, A. L., Andrade, B. F., Aitken, M., Mahleka, D., Jani, M., Frayne, M., Wong, J. K. Y., Kelly, R., Dickie, E. W., ... Voineskos, A. N. (2024). The Toronto Adolescent and Youth Cohort Study: Study Design and Early Data Related to Psychosis Spectrum Symptoms, Functioning, and Suicidality. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 9(3), 253-264. https://doi.org/10.1016/j.bpsc.2023.10.011

@article{717e3d0150be408e9ed3360402cc7eab,

title = "The Toronto Adolescent and Youth Cohort Study: Study Design and Early Data Related to Psychosis Spectrum Symptoms, Functioning, and Suicidality",

abstract = "BACKGROUND: Psychosis spectrum symptoms (PSSs) occur in a sizable percentage of youth and are associated with poorer cognitive performance, poorer functioning, and suicidality (i.e., suicidal thoughts and behaviors). PSSs may occur more frequently in youths already experiencing another mental illness, but the antecedents are not well known. The Toronto Adolescent and Youth (TAY) Cohort Study aims to characterize developmental trajectories in youths with mental illness and understand associations with PSSs, functioning, and suicidality.METHODS: The TAY Cohort Study is a longitudinal cohort study that aims to assess 1500 youths (age 11-24 years) presenting to tertiary care. In this article, we describe the extensive diagnostic and clinical characterization of psychopathology, substance use, functioning, suicidality, and health service utilization in these youths, with follow-up every 6 months over 5 years, including early baseline data.RESULTS: A total of 417 participants were enrolled between May 4, 2021, and February 2, 2023. Participants met diagnostic criteria for an average of 3.5 psychiatric diagnoses, most frequently anxiety and depressive disorders. Forty-nine percent of participants met a pre-established threshold for PSSs and exhibited higher rates of functional impairment, internalizing and externalizing symptoms, and suicidality than participants without PSSs.CONCLUSIONS: Initial findings from the TAY Cohort Study demonstrate the feasibility of extensive clinical phenotyping in youths who are seeking help for mental health problems. PSS prevalence is much higher than in community-based studies. Our early data support the critical need to better understand longitudinal trajectories of clinical youth cohorts in relation to psychosis risk, functioning, and suicidality.",

author = "Kristin Cleverley and George Foussias and {TAY Cohort Study Team} and Ameis, {Stephanie H} and Courtney, {Darren B} and Goldstein, {Benjamin I} and Hawke, {Lisa D} and Nicole Kozloff and Quilty, {Lena C} and Martin Rotenberg and Wheeler, {Anne L} and Andrade, {Brendan F} and Madison Aitken and Don Mahleka and Melanie Jani and Margot Frayne and Wong, {Jimmy K Y} and Rachel Kelly and Dickie, {Erin W} and Daniel Felsky and Haltigan, {John D} and Meng-Chuan Lai and Nikolova, {Yuliya S} and Wanda Tempelaar and Wei Wang and Marco Battaglia and Husain, {Muhammad Omair} and Sean Kidd and Paul Kurdyak and Levitan, {Robert D} and Lewis, {Stephen P} and Alexia Polillo and Peter Szatmari and {van der Miesen}, {Anna I R} and Masoud Ahmadzadasl and Voineskos, {Aristotle N} and Wanda Tempelaar",

note = "Publisher Copyright: {\textcopyright} 2023 Society of Biological Psychiatry",

year = "2024",

month = mar,

doi = "10.1016/j.bpsc.2023.10.011",

language = "English",

volume = "9",

pages = "253--264",

journal = "Biological Psychiatry: Cognitive Neuroscience and Neuroimaging",

issn = "2451-9022",

publisher = "Elsevier Inc.",

number = "3",

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Cleverley, K, Foussias, G, TAY Cohort Study Team, Ameis, SH, Courtney, DB, Goldstein, BI, Hawke, LD, Kozloff, N, Quilty, LC, Rotenberg, M, Wheeler, AL, Andrade, BF, Aitken, M, Mahleka, D, Jani, M, Frayne, M, Wong, JKY, Kelly, R, Dickie, EW, Felsky, D, Haltigan, JD, Lai, M-C, Nikolova, YS, Tempelaar, W , Wang, W, Battaglia, M, Husain, MO, Kidd, S, Kurdyak, P, Levitan, RD, Lewis, SP, Polillo, A, Szatmari, P, van der Miesen, AIR, Ahmadzadasl, M & Voineskos, AN 2024, 'The Toronto Adolescent and Youth Cohort Study: Study Design and Early Data Related to Psychosis Spectrum Symptoms, Functioning, and Suicidality', Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, vol. 9, no. 3, pp. 253-264. https://doi.org/10.1016/j.bpsc.2023.10.011

The Toronto Adolescent and Youth Cohort Study: Study Design and Early Data Related to Psychosis Spectrum Symptoms, Functioning, and Suicidality. / Cleverley, Kristin; Foussias, George; TAY Cohort Study Team et al.
In: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, Vol. 9, No. 3, 03.2024, p. 253-264.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - The Toronto Adolescent and Youth Cohort Study

T2 - Study Design and Early Data Related to Psychosis Spectrum Symptoms, Functioning, and Suicidality

AU - Cleverley, Kristin

AU - Foussias, George

AU - TAY Cohort Study Team

AU - Ameis, Stephanie H

AU - Courtney, Darren B

AU - Goldstein, Benjamin I

AU - Hawke, Lisa D

AU - Kozloff, Nicole

AU - Quilty, Lena C

AU - Rotenberg, Martin

AU - Wheeler, Anne L

AU - Andrade, Brendan F

AU - Aitken, Madison

AU - Mahleka, Don

AU - Jani, Melanie

AU - Frayne, Margot

AU - Wong, Jimmy K Y

AU - Kelly, Rachel

AU - Dickie, Erin W

AU - Felsky, Daniel

AU - Haltigan, John D

AU - Lai, Meng-Chuan

AU - Nikolova, Yuliya S

AU - Tempelaar, Wanda

AU - Wang, Wei

AU - Battaglia, Marco

AU - Husain, Muhammad Omair

AU - Kidd, Sean

AU - Kurdyak, Paul

AU - Levitan, Robert D

AU - Lewis, Stephen P

AU - Polillo, Alexia

AU - Szatmari, Peter

AU - van der Miesen, Anna I R

AU - Ahmadzadasl, Masoud

AU - Voineskos, Aristotle N

AU - Tempelaar, Wanda

PY - 2024/3

Y1 - 2024/3

N2 - BACKGROUND: Psychosis spectrum symptoms (PSSs) occur in a sizable percentage of youth and are associated with poorer cognitive performance, poorer functioning, and suicidality (i.e., suicidal thoughts and behaviors). PSSs may occur more frequently in youths already experiencing another mental illness, but the antecedents are not well known. The Toronto Adolescent and Youth (TAY) Cohort Study aims to characterize developmental trajectories in youths with mental illness and understand associations with PSSs, functioning, and suicidality.METHODS: The TAY Cohort Study is a longitudinal cohort study that aims to assess 1500 youths (age 11-24 years) presenting to tertiary care. In this article, we describe the extensive diagnostic and clinical characterization of psychopathology, substance use, functioning, suicidality, and health service utilization in these youths, with follow-up every 6 months over 5 years, including early baseline data.RESULTS: A total of 417 participants were enrolled between May 4, 2021, and February 2, 2023. Participants met diagnostic criteria for an average of 3.5 psychiatric diagnoses, most frequently anxiety and depressive disorders. Forty-nine percent of participants met a pre-established threshold for PSSs and exhibited higher rates of functional impairment, internalizing and externalizing symptoms, and suicidality than participants without PSSs.CONCLUSIONS: Initial findings from the TAY Cohort Study demonstrate the feasibility of extensive clinical phenotyping in youths who are seeking help for mental health problems. PSS prevalence is much higher than in community-based studies. Our early data support the critical need to better understand longitudinal trajectories of clinical youth cohorts in relation to psychosis risk, functioning, and suicidality.

AB - BACKGROUND: Psychosis spectrum symptoms (PSSs) occur in a sizable percentage of youth and are associated with poorer cognitive performance, poorer functioning, and suicidality (i.e., suicidal thoughts and behaviors). PSSs may occur more frequently in youths already experiencing another mental illness, but the antecedents are not well known. The Toronto Adolescent and Youth (TAY) Cohort Study aims to characterize developmental trajectories in youths with mental illness and understand associations with PSSs, functioning, and suicidality.METHODS: The TAY Cohort Study is a longitudinal cohort study that aims to assess 1500 youths (age 11-24 years) presenting to tertiary care. In this article, we describe the extensive diagnostic and clinical characterization of psychopathology, substance use, functioning, suicidality, and health service utilization in these youths, with follow-up every 6 months over 5 years, including early baseline data.RESULTS: A total of 417 participants were enrolled between May 4, 2021, and February 2, 2023. Participants met diagnostic criteria for an average of 3.5 psychiatric diagnoses, most frequently anxiety and depressive disorders. Forty-nine percent of participants met a pre-established threshold for PSSs and exhibited higher rates of functional impairment, internalizing and externalizing symptoms, and suicidality than participants without PSSs.CONCLUSIONS: Initial findings from the TAY Cohort Study demonstrate the feasibility of extensive clinical phenotyping in youths who are seeking help for mental health problems. PSS prevalence is much higher than in community-based studies. Our early data support the critical need to better understand longitudinal trajectories of clinical youth cohorts in relation to psychosis risk, functioning, and suicidality.

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U2 - 10.1016/j.bpsc.2023.10.011

DO - 10.1016/j.bpsc.2023.10.011

M3 - Article

C2 - 37979943

SN - 2451-9022

VL - 9

SP - 253

EP - 264

JO - Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

JF - Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

IS - 3

ER -

The Toronto Adolescent and Youth Cohort Study: Study Design and Early Data Related to Psychosis Spectrum Symptoms, Functioning, and Suicidality

Abstract

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